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Search Results for " annealing "

Targets Recommended: Apoptosis Others TLR

2

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12516	Polyinosinic-polycytidylic acid sodium 双链聚肌胞,Poly(I:C) sodium	Apoptosis; Others; TLR	Apoptosis; Immunology/Inflammation; Others
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) 是双链 RNA 的合成类似物，是TLR3和视黄酸诱导型基因 I 受体激动剂。它可以用作疫苗佐剂，直接触发癌细胞发生凋亡，还增强先天性和适应性免疫反应，并改变肿瘤的微环境。
T10936	D-I03 DI03	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	D-I03 是一种选择性的RAD52 抑制剂，Kd 为 25.8 µM。D-I03 抑制 RAD52 依赖性单链退火 (SSA) 和 D 环形成，IC50 分别为 5 µM 和 8 µM。D-I03 抑制 BRCA1 和 BRCA2 缺陷细胞的生长，并抑制顺铂诱导的 RAD52 病灶形成，但对 RAD51 无影响。

化合物

Polyinosinic-polycytidylic acid sodium

Cat.No: T12516

Synonym: 双链聚肌胞,Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Cat.No: T10936

Synonym: DI03

Target: DNA/RNA Synthesis

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-03440	RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) RAD52,DNA repair and recombination protein RAD52	Saccharomyces cerevisiae	E. coli
	Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.1 kDa and the accession number is P06778.
TMPH-02649	FAN1 Protein, Mouse, Recombinant (His & Myc) Fanconi-associated nuclease 1,Myotubularin-related protein 1...	Mouse	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to e...
TMPH-00561	30S ribosomal protein S4 Protein, E. coli, Recombinant (His) Small ribosomal subunit protein uS4,ramA,rpsD,30S ribosomal ...	E. coli	E. coli
	One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.; With S5 and S12 plays an important role in translational accuracy; many suppressors of streptomycin-dependent mutants of protein S12 are found in this protein, some but not all of which decrease translational accuracy (ram, ribosomal ambiguity mutations).; Plays a role in mRNA unwinding by the ribosome, possibly by forming part of a processivity c...

重组蛋白

RAD52 Protein, S. cerevisiae, Recombinant (His & SUMO)

Cat.No: TMPH-03440

Species: Saccharomyces cerevisiae

Expression System: E. coli

FAN1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02649

Species: Mouse

Expression System: E. coli

30S ribosomal protein S4 Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00561

Species: E. coli

Expression System: E. coli

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