ald-ph-amido-peg-3-c-cooh

Ald-Ph-amido-PEG3-C-COOH is a noncleavable linker utilized in the formation of antibody-drug conjugates (ADCs).

Ald-Ph-NHS ester 是用于抗体-药物偶联的不可切割接头。

Thalidomide-O-amido-PEG-C2-NH2 hydrochloride 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。它可用于 PROTAC 的合成分子。

Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) 包含基于 Pomalidomide 的 cereblon 配体和 4 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。

Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 的合成分子。

m-PEG2-O-Ph-3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is a chemical compound that features a cereblon (CRBN) ligand, functioning as an E3 ubiquitin ligase, along with a linker. It can be utilized to create the PROTAC MD-224[1].

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest.

Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker employed in ADC synthesis[1].

Boc-Gly-amido-C-PEG3-C3-amine is a polyethylene glycol (PEG)-based PROTAC linker employed in PROTAC synthesis[1].

Ald-Ph-amido-PEG1-C2-Pfp ester is a non-cleavable 1-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Ald-Ph-amido-C2-PEG3-NH-Boc is a polyethylene glycol (PEG)-based bifunctional linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-derived PROTAC linker suitable for PROTACs synthesis[1].

Ald-Ph-amido-PEG24-acid is a polyethylene glycol (PEG)-based linker used for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Ald-Ph-amido-PEG3-C2-Pfp ester is a noncleavable antibody-drug conjugate (ADC) linker that falls under the category of polyethylene glycol (PEG) linkers.

Ald-Ph-PEG2-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker employed in PROTACs synthesis[1].

Ald-Ph-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative primarily employed as a noncleavable ADC linker[1].

Ald-Ph-amido-PEG2-C2-NHS ester is a non-cleavable 2-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Thalidomide-O-amido-C3-COOH is a synthesized conjugate of an E3 ligase ligand-linker compound that combines a cereblon ligand derived from Thalidomide with a linker commonly employed in PROTAC technology.

Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].

Ald-Ph-amido-PEG4-C2-NHS ester is a non-cleavable 4-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Ald-Ph-PEG12-TFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG5-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-(PEG)3-VC-PAB-MMAE is a chemical compound where monomethyl auristatin E (MMAE), a potent tubulin inhibitor acting as a toxin payload in antibody-drug conjugates, is conjugated to a DBCO-(PEG)3-vc-PAB linker.

Thalidomide-O-amido-PEG-C2-NH2 is a synthesized conjugate formulation designed as an E3 ligase ligand-linker conjugate. It incorporates a cereblon ligand based on Thalidomide and a linker component commonly utilized in PROTAC technology.

Amino-PEG6-amido-C16-COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Ald-Ph-amido-PEG2-C2-Boc is a polyethylene glycol (PEG)-based linker utilized for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Ald-Ph-amido-PEG2-C2-Pfp ester is a non-cleavable 2-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Ald-Ph-amido-PEG4-C2-acid is a noncleavable linker utilized in the development of antibody-drug conjugates (ADC).

Ald-Ph-amido-PEG23-OPSS is a cleavable 23-unit polyethylene glycol linker commonly employed for the synthesis of antibody-drug conjugates (ADCs)[1].

Ald-Ph-amido-C2-PEG2-amine is a polyethylene glycol (PEG)-based linker utilized for the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].

Ald-Ph-amido-PEG2-C2-acid is a PEG-based PROTAC linker utilized for synthesizing PROTACs[1].

Ald-Ph-amido-PEG3-C1-Boc is a polyethylene glycol (PEG) linker specific to antibody-drug conjugates (ADC).

Ald-Ph-PEG24-TFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Pomalidomide-amido-C3-COOH is a conjugate compound synthesized as an E3 ligase ligand-linker. It combines a cereblon ligand derived from Pomalidomide with a linker, both of which are used in PROTAC technology.

Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a polyethylene glycol (PEG)-based proteolysis targeting chimera (PROTAC) linker, utilized for synthesizing PROTACs.

Ald-Ph-amido-PEG2 is a noncleavable ADC linker for antibody-drug conjugates (ADCs)[1].

Ald-Ph-PEG24-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.

Ald-Ph-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized conjugate compound known as an E3 ligase ligand-linker. It incorporates a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology applications.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly utilized in PROTAC technology. This compound acts as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

Ald-Ph-amido-PEG1-C2-NHS ester is a non-cleavable 1-unit PEG linker employed in antibody-drug conjugation (ADC) to connect antibodies with drugs.

Ald-Ph-PEG6-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG4-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.