β-amanitin

β-Amanitin, a cyclic peptide toxin found in the poisonous Amanita phalloides mushroom, inhibits eukaryotic RNA polymerase II and III, thereby disrupting protein synthesis.

γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin.

Mal-C6-α-Amanitin is a drug-linker conjugate for ADC with potent antitumor activity by using α-Amanitin (an RNA polymerase II inhibitor), linked via the ADC linker Mal-C6.

MC-VC-PABC-C6-alpha-Amanitin是一款针对HER2受体的ADC，包含致癌毒素alpha-Amanitin及单克隆抗体MC-VC-PABC-C6。alpha-Amanitin主要抑制RNA聚合酶IIα。该化合物专一性地靶向HER2阳性肿瘤细胞，主要应用于乳腺癌与胃癌的研究领域。

ε-Amanitin is a cyclic peptide obtained from various mushroom species. It exhibits a strong affinity for RNA polymerase II and effectively inhibits its activity.

Dideoxy-amanitin (compound 2) 是一种α-Amanitin 衍生物，是一种强效和选择性的 RNA 聚合酶 II 变结构抑制剂，其 IC50值为 74.2 nM。

alpha-Amanitin (α-Amanitin) 是鹅膏菌中致命的毒素，过肠肝循环和运输系统在体内起作用。alpha-Amanitin 可诱导细胞死亡，可用于合成 ADC。