(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria.
1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity.It can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification by inhibiting phosphate cotransporter (PiT-1) gene expression. It also shows moderate antiangiogenic activity against human tumor cells.
7-Isopentenyloxy-gamma-fagarine has highly cytotoxicity against the MCF-7and Jurkat cell line. It has been used as a precursor for the chemical asymmetric synthesis of the enantiopure alkaloids: evoxine, anhydroevoxine and evodine.
Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.
(2S,3S,4R,2'R)-2-(2'-hydroxytetracosanoylamino)octadecane-1,3,4-triol shows selectively inhibitory activity against phospholipase A 2 (PLA 2) secreted from Crotalus adamenteus venom at concentration of 100 ug mL.
Evodol may as an anti-inflammatory agent or lead compound, it shows inhibitory activity on nitric oxide (NO) production in lipopolysaccharide -activated RAW264.7 macrophages. Evodol and limonin possess larvicidal activity against the Asian tiger mosquitoe
1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A.