target/EGFR/6

EGFRT790M L858R-IN-6 (compound 53) 为一种嘧啶类化合物，作用为高效的EGFRT790M L858R抑制剂。在0.05 μM的浓度条件下，该化合物能够抑制90.88%的酶活性。

PROTACEGFRdegrader 6 是一种PROTACEGFR 降解剂，可有效降解 HCC827 细胞中的EGFRDel19，DC50为 45.2 nM。PROTACEGFRdegrader 6 显著诱导 HCC827 细胞凋亡 (apoptosis) 并将细胞阻滞在 G1 期。

EGFR HER2-IN-6 (compound 43) is a dual EGFR HER2 and DHFR inhibitor with potent activity against EGFR kinase, HER2 kinase, and DHFR, characterized by IC50 values of 0.122 μM, 0.078 μM, and 0.585 μM, respectively. This compound displays notable anticancer properties in various cancer cell lines, while demonstrating a favorable safety profile and selectivity indices. Consequently, EGFR HER2-IN-6 holds promise as a valuable tool in cancer research [1].