首页工具

登录

搜索结果

Search Results for " tetrahydrofolate "

Targets Recommended: Others Antifolate

16

抑制剂 & 化合物

2

天然产物

3

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T7598	Calcium N5-methyltetrahydrofolate 5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328	Others; Antifolate	Cell Cycle/Checkpoint; Others
	Calcium N5-methyltetrahydrofolate (NSC-173328) 是左旋叶酸的钙盐，用于治疗心血管疾病、乳腺癌和结肠直肠癌。
T29461	5-Methyltetrahydrofolate triglutamate 5-Me-Thf(glu)3	Others	Others
	5-Methyltetrahydrofolate triglutamate is a form of folic acid.
T8003	Methotrexate disodium	Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Methotrexate disodium 是一种叶酸类似物代谢抑制剂，具有免疫抑制剂和抗肿瘤特性，用于类风湿关节炎和研究多种癌症。
T20339	7-Hydroxymethotrexate NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962	Drug Metabolite	Metabolism
	7-Hydroxymethotrexate 是 Methotrexate 主要的代谢产物。Methotrexate 对叶酸具有抑制作用，抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸，并抑制 DNA 合成。Methotrexate 对代谢也具有抑制作用。
T24985	5-Monobutyl methotrexate NSC-305986,gamma-Mbmtx,NSC 305986,NSC305986	Others	Others
	5-Monobutyl methotrexate is an antineoplastic antimetabolite with immunosuppressant properties. It is a TETRAHYDROFOLATE DEHYDROGENASE inhibitor and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component
T76131	Sarcosine oxidase	Others	Others
	Sarcosine oxidase(SAO)，即肌氨酸氧化酶，可以催化肌氨酸的氧化去甲基化生成甘氨酸，H2O2, 5,10-CH2-四氢叶酸，常用于生化反应。
T69177	Methotrexate di-n-butyl ester	Others	Others
	Methotrexate di-n-butyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
T69257	Methotrexate diethyl ester	Others	Others
	Methotrexate diethyl ester is an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofoltae dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
T25374	Emofolin sodium NSC139490,MeTHHF disodium,NSC-139490,NSC 139490	Others	Others
	Emofolin sodium is the sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity，which competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, deple
T25980	Pralatrexate, (R)-	Others	Others
	Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr
T7730L	Aminopterin sodium NSC739,NSC 739 [as the base],NSC-739	Others	Others
	Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effe
T37998	N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)	Others	Others
	N-(4-Aminobenzoyl)-L-glutamic acid is an oxidation product and a metabolite of tetrahydrofolate.1Levels of N-(4-aminobenzoyl)-L-glutamic acid are increased in the plasma of mice fed a high folic acid-containing diet.2 1.Reed, L.S., and Archer, M.C.Oxidation of tetrahydrofolic acid by airJ. Agric. Food Chem.28(4)801-805(1980) 2.Burton, M.A., Antoun, E., Penailillo, R.S., et al.Folic acid induces intake-related changes in the mammary tissue transcriptome of C57BL/6 miceNutrients12(9)2821(2020)
T25079	Aminopterin N-hydroxysuccinimide ester Nhs-aminopterin,N-Hydroxysuccinimide aminopterin	Others	Others
	Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrof
T25981	Pralatrexate, (S)-	Others	Others
	Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intr
T74009	1,1,3-Tribromoacetone	Others	Others
	1,1,3-Tribromoacetone 是甲氨蝶呤的杂质。Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate)，可抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。
T32705	Levomefolate magnesium L-Methylfolate magnesium	Others	Others
	Levomefolate magnesium is the magnesium salt of the metabolite of folic acid (Vitamin B9) and it is a predominant active form of folate found in foods and in the blood circulation, accounting for 98% of folates in human plasma. It is transported across th

化合物

Calcium N5-methyltetrahydrofolate

Cat.No: T7598

Synonym: 5-甲基四氢叶酸钙,N5-甲基四氢叶酸钙,NSC173328

Target: Others, Antifolate

5-Methyltetrahydrofolate triglutamate

Cat.No: T29461

Synonym: 5-Me-Thf(glu)3

Target: Others

Methotrexate disodium

Cat.No: T8003

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate, ADC Cytotoxin

7-Hydroxymethotrexate

Cat.No: T20339

Synonym: NSC 380963,NSC-380963,NSC380962,NSC380963,NSC 380962,NSC-380962

Target: Drug Metabolite

5-Monobutyl methotrexate

Cat.No: T24985

Synonym: NSC-305986,gamma-Mbmtx,NSC 305986,NSC305986

Target: Others

Sarcosine oxidase

Cat.No: T76131

Target: Others

Methotrexate di-n-butyl ester

Cat.No: T69177

Target: Others

Methotrexate diethyl ester

Cat.No: T69257

Target: Others

Emofolin sodium

Cat.No: T25374

Synonym: NSC139490,MeTHHF disodium,NSC-139490,NSC 139490

Target: Others

Pralatrexate, (R)-

Cat.No: T25980

Target: Others

Aminopterin sodium

Cat.No: T7730L

Synonym: NSC739,NSC 739 [as the base],NSC-739

Target: Others

N-(4-Aminobenzoyl)-L-glutamic Acid (hydrate)

Cat.No: T37998

Target: Others

Aminopterin N-hydroxysuccinimide ester

Cat.No: T25079

Synonym: Nhs-aminopterin,N-Hydroxysuccinimide aminopterin

Target: Others

Pralatrexate, (S)-

Cat.No: T25981

Target: Others

1,1,3-Tribromoacetone

Cat.No: T74009

Target: Others

Levomefolate magnesium

Cat.No: T32705

Synonym: L-Methylfolate magnesium

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1153	Trimethoprim NIH 204,BW 56-72,甲氧苄啶,NSC-106568	DHFR; DNA/RNA Synthesis; Antifolate; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Trimethoprim (NSC-106568) 是抑菌抗生素，也是具有口服活性的二氢叶酸还原酶抑制剂。它对多种革兰氏阳性和革兰氏阴性需氧细菌具有活性，可用于尿路感染，肺孢子菌肺炎和志贺氏菌病的研究。
T13516	5-Methyltetrahydrofolic acid 甲基叶酸盐,5-Methyl THF	Endogenous Metabolite	Metabolism
	5-Methyltetrahydrofolic acid (5-Methyl THF) 是四氢叶酸的甲基化衍生物，具有生物活性。5-Methyltetrahydrofolic acid 是主要的天然膳食叶酸，是血浆和脑脊液中叶酸的主要形式。

天然产物

Cat.No: T1153

Synonym: NIH 204,BW 56-72,甲氧苄啶,NSC-106568

Target: DHFR, DNA/RNA Synthesis, Antifolate, Antibacterial, Antibiotic

5-Methyltetrahydrofolic acid

Cat.No: T13516

Synonym: 甲基叶酸盐,5-Methyl THF

Target: Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00989	MTHFS Protein, Human, Recombinant (His) 5-formyltetrahydrofolate cyclo-ligase,10-methenyl-<...	Human	E. coli
	5-formyltetrahydrofolate cyclo-ligase (MTHFS) belongs to the 5-formyltetrahydrofolate cyclo-ligase family. It is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, contributes to tetrahydrofolate metabolism. MTHFS helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. An increased activity of the encoded protein can result in an increas...
TMPJ-00484	SHMT1 Protein, Human, Recombinant (His) Serine Methylase,Glycine Hydroxymethyltransferase,Serine Hyd...	Human	HEK293 Cells
	Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ...
TMPY-03503	GCSH Protein, Human, Recombinant (His) glycine cleavage system protein H (aminomethyl carrier),NKH,...	Human	E. coli
	Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). GCSH is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in GCSH gene are a cause of nonketotic h...

重组蛋白

MTHFS Protein, Human, Recombinant (His)

Cat.No: TMPJ-00989

Species: Human

Expression System: E. coli

SHMT1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00484

Species: Human

Expression System: HEK293 Cells

GCSH Protein, Human, Recombinant (His)

Cat.No: TMPY-03503

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼