Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated inSort1knockout mice at 24 hours post-BDL.2 1.Lefebvre, P., Cariou, B., Lien, F., et al.Role of bile acids and bile acid receptors in metabolic regulationPhysiol. Rev.89(1)147-191(2009) 2.Li, J., Woolbright, B.L., Zhao, W., et al.Sortilin 1 loss-of-function protects against cholestatic liver injury by attenuating hepatic bile acid accumulation in bile duct ligated miceToxicol. Sci.161(1)34-47(2018)
Prasterone is an endogenous steroid hormone. Prasterone acts as an agonist at ERβ, NMDA, and σ1 receptors, a partial agonist at ERα and AR, and antagonist at GABA-A receptors. It displays a variety of biologocial activities, including enhancing working me
Taurolithocholic acid 3-sulfate (TLCA3S) is a metabolite of the conjugated bile acid taurolithocholic acid . TLCA3S has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis.
Moxifloxacin N-sulfate is a metabolite of moxifloxacin . Moxifloxacin is a fluoroquinolone antibiotic. Formulations containing moxifloxacin have been used in the treatment of bacterial infections, including sinusitis, chronic bronchitis, and pneumonia.
Aldosterone 21-sulfate is a metabolite of the steroid hormone aldosterone .1It reduces the sodium-to-potassium ratio in rat urine when administered at doses ranging from 10 to 100 μg, indicating mineralocorticoid activity that is less than 1% that of aldosterone.2 1.Grose, J.H., Nowaczynski, W., Kuchel, O., et al.Isolation of aldosterone urinary metabolites, glucuronides and sulfateJ. Steroid Biochem.4(6)551-566(1973) 2.Jowett, T.P., and Slater, J.D.H.Aldosterone 21-sulphate in manJ. Steroid. Biochem.18(4)471-479(2019)
Sitagliptin N-sulfate is a phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin . Sitagliptin N-sulfate is formed via sulfation and has been found in rat bile following oral administration of (-)-sitagliptin.
Resveratrol-3-O-sulfate is a metabolite of resveratrol . In U-937 cells stimulated with LPS, resveratrol-3-O-sulfate (1 μM) decreases the expression of IL-1α, IL-1β, and IL-6 by 61.2, 76.6, and 42.2%, respectively, and decreases the release of TNF-α and IL-6 to similar levels as resveratrol. It has antioxidant activity in a Trolox assay, dose-dependently decreases growth of Caco-2 colorectal adenocarcinoma cells when used at concentrations ranging from 10 to 100 μM, and induces apoptosis at concentrations of 25 and 50 μM. Resveratrol-3-O-sulfate also displaces rosiglitazone from the outer mitochondrial protein mitoNEET (IC50 = 3.36 μM for the human protein), indicating that it binds to the thiazolidine-2,4-dione (TZD) binding pocket.
(±)-Equol 4’-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol .[1] It has been used as a standard for the quantification of unconjugated equol in rat plasma.[2]
Dehydroepiandrosterone SulfateSodium Salt-d6 是 Dehydroepiandrosterone SulfateSodium Salt 的氘代化合物。Dehydroepiandrosterone SulfateSodium Salt 的 CAS 号为 1099-87-2。