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Search Results for " snake "

Targets Recommended: Others

11

抑制剂 & 化合物

4

天然产物

1

化合物库

13

重组蛋白

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Cat. No.	Product Name
L7300	钾通道分子库		152 compounds
	152 种钾通道相关化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

钾通道分子库

Cat.No: L7300

Compounds: 152

Cat. No.	Product Name	Target	Signaling Pathways
TP1289	Cardiotoxin Analog (CTX) IV (6-12) TFA Cardiotoxin Analog (CTX) IV (6-12) (TFA)(115722-23-1,FREE)	Others	Others
	Cardiotoxin Analog (CTX) IV (6-12) TFA(115722-23-1 free base) 是 Cardiotoxin Analog (CTX) IV 的部分肽。从台湾眼镜蛇毒液中分离出的心脏毒素类似物 IV。 CTX IV 是一种独特的蛇毒心脏毒素。
T80468	δ-Dendrotoxin	Potassium Channel	Membrane transporter/Ion channel
	δ-Dendrotoxin，作为一种K+通道阻滞剂，来源于黑曼巴蛇的毒液，常用于研究神经系统疾病。
T26212	SQ 20858 SQ 20,858,SQ20858,SQ-20858,SQ-20,858,SQ20,858	Others	Others
	SQ 20858 is a synthetic peptide derived from snake Bothrops jararaca venom; suppresses angiotensin serum converting enzyme.
T81787	MitTx-beta
	MitTx-beta为一多肽，源自得克萨斯珊瑚蛇(Micrurus tener tener)之毒液。与MitTx-α配对，组成复合物MitTx，此复合物激活ASIC1通道，存在于辣椒素敏感神经纤维上。
T75582	Naja Melanoleuca Venom	Others	Others
	Naja Melanoleuca Venom (Forest Cobra Venom) 是一种蛇毒，可从 Naja Melanoleuca 获得。Naja Melanoleuca Venom 对人类红细胞具有溶血活性。α-神经毒素可以从 Naja Melanoleuca 毒液中分离出来，并抑制 GABAA 受体功能。
T80064	Dendrotoxin-I DTX-I	Potassium Channel	Membrane transporter/Ion channel
	Dendrotoxin-I是一种高效的K+通道阻滞剂，特异性针对KV1.1和KV1.2电压门控钾通道亚基。该化合物为从Dendroaspis蛇毒中提取的神经毒素。
T75408	Batroxobin	Others	Others
	Batroxobin (DF-521)，一种从Bothrops atrox moojeni获得的蛇毒，能促进血栓溶解，防止血栓复发并具有神经保护作用，显示出在脑静脉血栓性疾病研究中的潜力。
T75585	Naja Mossambica Venom	Others	Others
	Naja Mossambica Venom (Mozambique Spitting Cobra Venom) 是一种蛇毒，可从 Naja Mossambica 获得。Naja Pallida Venom 对Candida 物种具有抗真菌活性。Naja Mossambica Venom 提取物 (如磷脂酶 A2) 可抑制钠钾 ATP 酶活性。
T75589	Bitis Cornuta Venom	Others	Others
	Bitis Cornuta Venom (Many-horned Adder Venom) 是从 Bitis Cornuta 提取的蛇毒，含有sPLA2毒素，该毒素具有通过抑制凝血酶原复合物以发挥抗凝活性的能力，并能促使凝血酶原转化为凝血酶，引发凝块形成。
T80487	MmTx2 toxin Micrurotoxin 2	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	MmTx2 toxin作为一种GABAA受体调节剂，具有提升GABAA受体对激动剂反应敏感性的作用。该毒素来源于珊瑚蛇的毒液，并在神经系统相关疾病（例如癫痫、精神分裂症及慢性疼痛）的研究中发挥重要用途。
T37832	CAY10761 CAY10761	Others	Others
	CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 \|1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p...

化合物

Cardiotoxin Analog (CTX) IV (6-12) TFA

Cat.No: TP1289

Synonym: Cardiotoxin Analog (CTX) IV (6-12) (TFA)(115722-23-1,FREE)

Target: Others

Cat.No: T80468

Target: Potassium Channel

Cat.No: T26212

Synonym: SQ 20,858,SQ20858,SQ-20858,SQ-20,858,SQ20,858

Target: Others

Cat.No: T81787

Naja Melanoleuca Venom

Cat.No: T75582

Target: Others

Cat.No: T80064

Synonym: DTX-I

Target: Potassium Channel

Cat.No: T75408

Target: Others

Naja Mossambica Venom

Cat.No: T75585

Target: Others

Bitis Cornuta Venom

Cat.No: T75589

Target: Others

Cat.No: T80487

Synonym: Micrurotoxin 2

Target: GABA Receptor

Cat.No: T37832

Synonym: CAY10761

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1788	Isookanin	Amylase	Metabolism
	Isookanin 在多种疾病领域有研究价值，包括肿瘤，皮疹，蛇和昆虫叮咬，糖尿病，腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。
TN4886	Quinovic acid 3-O-alpha-L-rhamnopyranoside	Others	Others
	Quinovic acid 3-O-alpha-L-rhamnopyranoside shows significant inhibitory activity against snake venom phosphodiesterase-I.
TN4247	Ikshusterol 3-O-glucoside	Phospholipase	Metabolism
	Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
T36295	Echistatin TFA	Others	Others
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...

天然产物

Cat.No: TN1788

Target: Amylase

Quinovic acid 3-O-alpha-L-rhamnopyranoside

Cat.No: TN4886

Target: Others

Ikshusterol 3-O-glucoside

Cat.No: TN4247

Target: Phospholipase

Cat.No: T36295

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00217	SVMP Protein, Bothrops leucurus, Recombinant (His & Myc) Snake venom metalloproteinase leucurolysin-A	Bothrops leucurus	E. coli
	Non-hemorrhagic metalloproteinase that hydrolyzes the alpha chains of fibrinogen, as well as fibrin, fibronectin and casein. Beta and gamma chains are also hydrolyzed, but more slowly. Thrombolytic activity is also observed. Induces detachment of endothelial cells followed by death, and inhibits endothelial cell adhesion to fibronectin. Induces edema in mouse paw. Inhibits ADP-induced platelet aggregation on human platelet-rich plasma with an IC(50) of 2.8 uM. SVMP Protein, Bothrops leucurus, Re...
TMPH-00214	SVMP Protein, Bothrops atrox, Recombinant (His & Myc) Snake venom metalloproteinase atroxlysin-1,Atroxlys...	Bothrops atrox	E. coli
	SVMP Protein, Bothrops atrox, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.4 kDa and the accession number is P85420.
TMPH-00450	SVSP Protein, Crotalus atrox, Recombinant (His) Kallikrein-like EI,Catroxase II,Snake venom serine ...	Crotalus atrox	P. pastoris (Yeast)
	SVSP Protein, Crotalus atrox, Recombinant (His) is expressed in Yeast.
TMPH-00451	SVSP Protein, Crotalus atrox, Recombinant (His & Myc) Kallikrein-like EI,Snake venom serine protease catr...	Crotalus atrox	Baculovirus Insect Cells
	Snake venom serine protease that may act in the hemostasis system of the prey. SVSP Protein, Crotalus atrox, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.1 kDa and the accession number is Q8QHK2.
TMPH-00448	SVMP Protein, Crotalus adamanteus, Recombinant (His) Adamalysin II,Proteinase II,Snake venom metalloprot...	Crotalus adamanteus	E. coli
	Has no significant hemorrhagic activity, but inactivates serpins by limited proteolysis of their reactive-site loops. SVMP Protein, Crotalus adamanteus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.1 kDa and the accession number is P34179.
TMPH-03163	SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc) Habutobin,Snake venom serine protease 1,Fibrinogen-...	Protobothrops flavoviridis	E. coli
	SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.1 kDa and the accession number is P05620.
TMPH-00038	Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) Snake venom serine protease,Thrombin-like enzyme co...	Agkistrodon contortrix	E. coli
	Thrombin-like snake venom serine protease that cleaves beta chain of fibrinogen (FGB), releasing fibrinopeptide B. Has a coagulant activity activating blood coagulation factors V (F5) and XIII (F13A1). Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.4 kDa and the accession number is P82981.
TMPH-00324	SVTLE Protein, Calloselasma rhodostoma, Recombinant (His) Thrombin-like enzyme ancrod,Snake venom serine prot...	Calloselasma rhodostoma	P. pastoris (Yeast)
	SVTLE Protein, Calloselasma rhodostoma, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 28.6 kDa and the accession number is P26324.
TMPH-00215	SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) Venombin A,Fibrinogen-clotting enzyme,Snake venom s...	Bothrops jararaca	E. coli
	Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and activates factor VIII (F8). SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is P81661.
TMPH-00768	SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc) Calobin I,Snake venom serine protease,Fibrinogen-cl...	Gloydius ussuriensis	E. coli
	Thrombin-like snake venom serine protease. Has a coagulant activity. Acts on alpha-chains of fibrinogen (FGA) generating fibrinopeptide A. SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.7 kDa and the accession number is Q91053.
TMPH-00216	SVMP Protein, Bothrops jararaca, Recombinant (His & KSI) Snake venom metalloproteinase,von Willebrand factor...	Bothrops jararaca	E. coli
	Metalloproteinase that binds to von Willebrand factor (VWF) and induces its interaction with GPIb (GP1BA), resulting in platelet aggregation. SVMP Protein, Bothrops jararaca, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.0 kDa and the accession number is P22028.
TMPY-02162	PLA2G2E Protein, Mouse, Recombinant (His) phospholipase A2, group IIE,Phospholipase A2 IIE	Mouse	HEK293 Cells
	Group IIE secretory phospholipase A2, also known as GIIE sPLA2, sPLA2-IIE, Phosphatidylcholine 2-acylhydrolase 2E and PLA2G2E is a secreted protein that belongs to the phospholipase A2 family. Mammalian secretory phospholipase A2s (sPLA2s) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via the release of arachidonic acid from membrane phospholipids or the binding to specific membrane receptors. Phospholipases A2 / PLA2 are...
TMPY-02181	PLA2G12B Protein, Mouse, Recombinant (His) Fksg71,2010002E04Rik,Pla2g13,hlb218,phospholipase A2, group ...	Mouse	HEK293 Cells
	Group XIIB secretory phospholipase A2-like protein, also known as Group XIII secretory phospholipase A2-like protein, GXIII sPLA2-like, sPLA2-GXIIB, GXIIB, PLA2G13 and PLA2G12B, is a secreted protein that belongs to the phospholipase A2 family. PLA2G12B / PLA2G13 is strongly expressed in liver, small intestine and kidney. Mammalian secretory phospholipase A2s ( sPLA2s ) form a family of structurally related enzymes that are involved in a variety of physiological and pathological processes via th...

重组蛋白

SVMP Protein, Bothrops leucurus, Recombinant (His & Myc)

Cat.No: TMPH-00217

Species: Bothrops leucurus

Expression System: E. coli

SVMP Protein, Bothrops atrox, Recombinant (His & Myc)

Cat.No: TMPH-00214

Species: Bothrops atrox

Expression System: E. coli

SVSP Protein, Crotalus atrox, Recombinant (His)

Cat.No: TMPH-00450

Species: Crotalus atrox

Expression System: P. pastoris (Yeast)

SVSP Protein, Crotalus atrox, Recombinant (His & Myc)

Cat.No: TMPH-00451

Species: Crotalus atrox

Expression System: Baculovirus Insect Cells

SVMP Protein, Crotalus adamanteus, Recombinant (His)

Cat.No: TMPH-00448

Species: Crotalus adamanteus

Expression System: E. coli

SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc)

Cat.No: TMPH-03163

Species: Protobothrops flavoviridis

Expression System: E. coli

Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc)

Cat.No: TMPH-00038

Species: Agkistrodon contortrix

Expression System: E. coli

SVTLE Protein, Calloselasma rhodostoma, Recombinant (His)

Cat.No: TMPH-00324

Species: Calloselasma rhodostoma

Expression System: P. pastoris (Yeast)

SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc)

Cat.No: TMPH-00215

Species: Bothrops jararaca

Expression System: E. coli

SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc)

Cat.No: TMPH-00768

Species: Gloydius ussuriensis

Expression System: E. coli

SVMP Protein, Bothrops jararaca, Recombinant (His & KSI)

Cat.No: TMPH-00216

Species: Bothrops jararaca

Expression System: E. coli

PLA2G2E Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02162

Species: Mouse

Expression System: HEK293 Cells

PLA2G12B Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02181

Species: Mouse

Expression System: HEK293 Cells

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