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Search Results for " scar "

Targets Recommended: Aquaporin PROTAC Linker

20

抑制剂 & 化合物

5

天然产物

1

化合物库

16

重组蛋白

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Cat. No.	Product Name
L9810	抗纤维化化合物库		1180 compounds
	1180 种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；

化合物库

抗纤维化化合物库

Cat.No: L9810

Compounds: 1180

Cat. No.	Product Name	Target	Signaling Pathways
T5102	TGN-020 TGN020	Aquaporin; PROTAC Linker	Membrane transporter/Ion channel; PROTAC
	TGN-020 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 的合成分子。TGN020 是一种选择性水通道蛋白 4 (AQP4) 抑制剂，IC50为 3.1 μM。TGN020 减轻大鼠脊髓压迫损伤后的水肿并抑制神经胶质瘢痕的形成。
T0220	Foscarnet sodium Phosphonoformate,膦甲酸钠	Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂，可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。
T80477	Muscarinic toxin 3 MT3	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Muscarinic toxin 3 (MT3) 是高效的非竞争性mAChR及adrenoceptors拮抗剂，对M1、M4、α1A、α1B、α1D、α2A、α2B、α2C受体展示出不同程度的选择性，其pIC50值分别为6.71、8.79、8.86、7.57、8.13、8.49、6.5、7.29。该化合物具有显著的肾上腺素受体抑制活性。
T60253	(±)-Muscarine chloride	Others	Others
	(±)-Muscarine chloride 是 Muscarine chloride 的外消旋体。Muscarine 是一种原型毒蕈碱乙酰胆碱受体 (mAChR) 激动剂。
T15339	Foscarbidopa Carbidopa 4′-monophosphate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Foscarbidopa is a prodrug of Carbidopa. It acts as a dopamine receptor agonist.
T20752	Biebrich scarlet NSC-79710,NSC79710,NSC 79710
	Biebrich scarlet is a scarlet dye, it has been used in Masson’s trichrome stain for the staining of collagen. It has also been used for the staining of eosinophil.
T23034	Muscarine iodide (+)-Muscarine iodide	Others	Others
	Muscarinic acetylcholine receptor agonist
T24507	Muscarine (+)-Muscarine,Muskarin	Others	Others
	Muscarine is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.
T81893	M1/M4 muscarinic agonist 2	Others	Others
	M1/M4 muscarinic antagonist 2（compound 40）为选择性抑制M1与M4受体的化合物，其IC50值分别为19 nM和42 nM。
T124690	Cascaroside A	Others	Others
	Cascaroside A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124690。
T24508	Muscarine chloride HSDB-3515,(+)-Muscarine chloride,HSDB 3515,L-(+)-Muscarine chloride,EINECS 218-963-2	Others	Others
	Muscarine chloride is a toxic alkaloid found in Amanita muscaria and other fungi of the Inocybe species.
T11000	Descarbamoyl cefuroxime	Others	Others
	Descarbamoyl cefuroxime is also an intermediate in the synthesis of cephalosporin antibiotics. Decarbamyl cefuroxime is a degradation product of cefuroxime.
T80183	Muscarinic toxin 7
	Muscarinic toxin 7，一种肽类毒素，特异性地针对毒蕈碱M1受体表现出选择性和非竞争性的拮抗活性。
T84726	Muscarine tosylate (+)-Muscarine tosylate	Others	Others
	Muscarine ((+)-Muscarine) tosylate 是一种原型毒蕈碱 mAChR 激动剂，能够刺激副交感神经系统的毒素。
T34563	Scaritoxin	Others	Others
	Scaritoxin is a potent toxic substance isolated from poisonous fish.
T84986	Descarbonyl Lacosamide DP-I	Others	Others
	Descarbonyl-lacosamide is a potential impurity in commercial lacosamide preparations. It is a degradation product that forms under acidic conditions.
T2270	Trans-Tranilast Tranilast trans-,反式-曲尼司特,反-曲尼司特	RAAS	Endocrinology/Hormones
	Trans-Tranilast 是抗过敏剂，可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。
T14139	Aganepag AGN 210937	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Aganepag, a potent Prostanoid EP2 receptor agonist, exhibits remarkable selectivity with an EC50 of 0.19 nM, demonstrating no activity at the EP4 receptor. Its applications are primarily in the fields of wound healing, scar reduction, scar prevention, and the treatment and prevention of wrinkles.
T37598	D-Glucosamine-6-sulfate	Others	Others
	D-Glucosamine-6-sulfate is a naturally occurring glycosaminoglycan. It activates the glmS ribozyme from B. subtilis, a Gram-positive bacterium, when used at a concentration of 200 μM. It has been used to form polyvalent dendrimer conjugates that inhibit angiogenesis and endothelial cell proliferation induced by FGF-2 in vitro and prevent scar tissue formation in a rabbit model of glaucoma surgery.
T60438	PXS-6302	Others	Others
	PXS-6302 是不可逆的赖氨酸氧化酶 (LOX) 抑制剂，对Bovine LOX、rh LOXL1、rh LOXL2、rh LOXL3、rh LOXL4的IC50分别为 3.7 μM，3.4 μM，0.4 μM，1.5 μM 和0.3 μM。PXS-6302 可以轻松渗透皮肤，减少胶原蛋白沉积和交联，显着改善疤痕外观而不降低组织强度。 PXS-6302 在其他纤维化疾病中也可能有更广泛的应用。

化合物

Cat.No: T5102

Synonym: TGN020

Target: Aquaporin, PROTAC Linker

Foscarnet sodium

Cat.No: T0220

Synonym: Phosphonoformate,膦甲酸钠

Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis

Muscarinic toxin 3

Cat.No: T80477

Synonym: MT3

Target: Adrenergic Receptor

(±)-Muscarine chloride

Cat.No: T60253

Target: Others

Cat.No: T15339

Synonym: Carbidopa 4′-monophosphate

Target: Dopamine Receptor

Biebrich scarlet

Cat.No: T20752

Synonym: NSC-79710,NSC79710,NSC 79710

Muscarine iodide

Cat.No: T23034

Synonym: (+)-Muscarine iodide

Target: Others

Cat.No: T24507

Synonym: (+)-Muscarine,Muskarin

Target: Others

M1/M4 muscarinic agonist 2

Cat.No: T81893

Target: Others

Cat.No: T124690

Target: Others

Muscarine chloride

Cat.No: T24508

Synonym: HSDB-3515,(+)-Muscarine chloride,HSDB 3515,L-(+)-Muscarine chloride,EINECS 218-963-2

Target: Others

Descarbamoyl cefuroxime

Cat.No: T11000

Target: Others

Muscarinic toxin 7

Cat.No: T80183

Muscarine tosylate

Cat.No: T84726

Synonym: (+)-Muscarine tosylate

Target: Others

Cat.No: T34563

Target: Others

Descarbonyl Lacosamide

Cat.No: T84986

Synonym: DP-I

Target: Others

Trans-Tranilast

Cat.No: T2270

Synonym: Tranilast trans-,反式-曲尼司特,反-曲尼司特

Target: RAAS

Cat.No: T14139

Synonym: AGN 210937

Target: Prostaglandin Receptor

D-Glucosamine-6-sulfate

Cat.No: T37598

Target: Others

Cat.No: T60438

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3809	Liriope muscari baily saponins C	Others	Others
	Liriope muscari baily saponins C 是一种L. muscari (Decne.) Baily 的主要活性成分。它已被作为肿瘤转移候选药物进行研究。它具有很强的抗炎、免疫药理和心脏保护作用。
T25114	Ascaridole NSC-406266,NSC 406266,NSC406266	Parasite	Microbiology/Virology
	Ascaridole (NSC-406266) 可作为驱虫化合物，能驱除人体和植物中的寄生蠕虫(蠕虫)，具有较弱的抗疟活性。
T5794	Saponin C from Liriope muscari Liriope muscari baily Saponins C	Autophagy	Autophagy
	Saponin C from Liriope muscari 可从百合科植物 Liriope muscari中提取,具有抗血栓活性,可诱导自噬。
T3876	Loureirin B 龙血素B,龙血素 B	PAI-1; ERK; Potassium Channel; JNK	MAPK; Membrane transporter/Ion channel; Metabolism
	Loureirin B 是从剑叶龙血树中分离到的一种黄酮，是 PAI-1抑制剂，IC50值为 26.10 μM。它抑制 KATP，以及 ERK 和 JNK 的磷酸化，具有抗糖尿病的功效。
T64812	Collagenase Type I Collagenase I,Collagenase Type I (From microorganisms)	Others	Others
	Collagenase Type I 是一种蛋白水解酶，能分解胶原蛋白中的肽键（胶原蛋白是结缔组织的主要结构蛋白）。Collagenase 已被探索作为一种潜在的治疗选择来分解突出的椎间盘物质，从而减少对附近神经的压迫。Collagenase 可能有助于过度疤痕组织的分解和重组，潜在地改善组织功能和外观。Collagenase 具有治疗椎间盘突出、瘢痕疙瘩、脂肪团、脂肪瘤以及佩罗尼氏病和手掌纤维瘤病等方面的潜力。

天然产物

Liriope muscari baily saponins C

Cat.No: T3809

Target: Others

Cat.No: T25114

Synonym: NSC-406266,NSC 406266,NSC406266

Target: Parasite

Saponin C from Liriope muscari

Cat.No: T5794

Synonym: Liriope muscari baily Saponins C

Target: Autophagy

Cat.No: T3876

Synonym: 龙血素B,龙血素 B

Target: PAI-1, ERK, Potassium Channel, JNK

Collagenase Type I

Cat.No: T64812

Synonym: Collagenase I,Collagenase Type I (From microorganisms)

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02767	TPP1 Protein, Human, Recombinant (His) tripeptidyl peptidase I,CLN2,TPP-1,SCAR7,GIG1,LPIC	Human	Baculovirus Insect Cells
	TPP1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.7 kDa and the accession number is AAH14863.1.
TMPY-01081	SR-BI/SCARB1 Protein, Human, Recombinant (His) SR-BI,SRB1,HDLQTL6,CD36L1,CLA-1,scavenger receptor class B, ...	Human	HEK293 Cells
	SR-BI/SCARB1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48 kDa and the accession number is A0A024RBS4.
TMPY-01097	SR-BI/SCARB1 Protein, Mouse, Recombinant (His & hFc) Cd36l1,Hdlq1,AI120173,Cla1,Cla-1,scavenger receptor class B,...	Mouse	HEK293 Cells
	SR-BI/SCARB1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 74 kDa and the accession number is Q61009-1.
TMPY-05498	SR-BI/SCARB1 Protein, Human, Recombinant (hFc) HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas...	Human	HEK293 Cells
	SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5.
TMPK-01092	OSCAR Protein, Human, Recombinant (hFc) Poly-Ig receptor 3,PIGR3,OSCAR,PIgR-3,MGC33613,mO	Human	HEK293 Cells
	Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and normal patients. OSCAR and tartrate-resistant acid phosphatase (TRAP) expression levels did not differ between the cartilage pannus junction (CPJ) and non-CPJ regions in active RA. OSCAR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The p...
TMPH-00047	DODA Protein, Amanita muscaria, Recombinant (His & Myc) DOPA 4,5-dioxygenase,DODA	Amanita muscaria	E. coli
	Extradiol dioxygenase that opens up the cyclic ring of DOPA between carbons 4 and 5 thus producing an unstable seco-DOPA that rearranges non-enzymatically to betalamic acid. Can also catalyze the formation of muscaflavin (a pigment found in the hygrocybe mushrooms family and of some amanita species only) by a 2,3-extradiol cleavage of DOPA. DODA Protein, Amanita muscaria, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight...
TMPH-02061	SCARB1 Protein, Human, Recombinant (His & SUMO) SCARB1,SR-BI,CD36 antigen-like 1,CD36 and LIMPII an...	Human	E. coli
	SCARB1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 62.7 kDa and the accession number is Q8WTV0.
TMPY-01098	SR-BI/SCARB1 Protein, Mouse, Recombinant (His) Cd36l1,AI120173,SRBI,Hlb398,Cla1,mSR-BI,Hdlq1,Cla-1,CD36,Srb...	Mouse	HEK293 Cells
	SR-BI/SCARB1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47 kDa and the accession number is Q61009-1.
TMPK-01117	OSCAR Protein, Mouse, Recombinant (hFc) PIgR-3,Poly-Ig receptor 3,OSCAR,MGC33613,mOSCAR...	Mouse	HEK293 Cells
	Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and normal patients. OSCAR and tartrate-resistant acid phosphatase (TRAP) expression levels did not differ between the cartilage pannus junction (CPJ) and non-CPJ regions in active RA. OSCAR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The p...
TMPY-02525	RGMA Protein, Human, Recombinant (His) repulsive guidance molecule family member a,RGM	Human	HEK293 Cells
	RGMa, also known as RGM domain family, member A, belongs to the RGM (repulsive guidance molecule) family whose members are membrane-associated glycoprotein. RGMa is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. It helps guide Retinal Ganglion Cell (RGC) axons to the tectum in the midbrain. RGMa has been implicated to play an important role in the developing brain and in the scar tissue that form...
TMPK-00258	Latent TGF beta 3 Protein, Human, Recombinant (His) TGFβ3,转化生长因子,TGF-β3,TGF-beta3,TGFβ,TGF-β,ARVD,TGFB3,Latent T...	Human	HEK293 Cells
	Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differentiation. And transforming growth factor beta3 (TGFbeta3) is a key protein involved in scar-free healing observed in embryos. Latent TGF beta 3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 45.9 kDa and t...
TMPY-04671	MCP-5 Protein, Mouse, Recombinant (His) chemokine (C-C motif) ligand 12,MCP-5,Scya12,CCL12	Mouse	P. pastoris (Yeast)
	Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impaired fibronectin and collagen deposition and indirectly stimulated collagen degradation through upregulation of matrix metalloproteinase-2. In post-MI patients, circulating LPS levels strongly associated with the Ccl12 homologue monocyte chemotactic protein 1 (MCP-1). Both MCP-1 ...
TMPK-00259	Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated TGF-beta3,TGFβ,TGF-β,TGF-β3,TGFB3,ARVD,TGFβ3,转化生长因子,Latent T...	Human	HEK293 Cells
	Transforming growth factor-betas (TGF-βs) are multifunctional cytokines that have been implicated in the regulation of a broad range of biological processes, including cell proliferation, cell survival, and cell differentiation. And transforming growth factor beta3 (TGFbeta3) is a key protein involved in scar-free healing observed in embryos. Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predi...
TMPJ-01369	DPT Protein, Mouse, Recombinant (hFc) EQ-1,Early quiescence protein 1,TRAMP,Tyrosine-rich acidic m...	Mouse	HEK293 Cells
	Dermatopontin is a widely expressed noncollagenous protein component of the extracellular matrix. It is a 22 kDa molecule that is tyrosine sulfated but not glycosylated. Dermatopontin is down regulated in fibrotic growths such as leiomyoma and scar tissue, inhibits cell proliferation, accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation, Dermatopontin deficient mice exhibit altered collagen matrix deposition and organization. Dermatopontin s...
TMPY-01846	Activin A Protein, Mouse, Recombinant (His) inhibin, β A,inhibin, beta A	Mouse	HEK293 Cells
	Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two β subunits, βA βA (activin A), βB βB (activin B), or βA βB (activin AB). Inhibin is composed of an alpha and one of two β subunits, βA (inhibin A) or βB (inhibin B). Activins are produced in...
TMPY-01190	INHBB Protein, Human, Recombinant (His) inhibin beta B,INHBB,Inhibin β B Protein,MGC157939,inhibin β...	Human	HEK293 Cells
	Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two ß subunits, ßA ßA (activin A), ßB ßB (activin B), or ßA ßB (activin AB). Inhibin is composed of an alpha and one of two ß subunits, ßA (inhibin A) or ßB (inhibin B). Activins are produced in...

重组蛋白

TPP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02767

Species: Human

Expression System: Baculovirus Insect Cells

SR-BI/SCARB1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01081

Species: Human

Expression System: HEK293 Cells

SR-BI/SCARB1 Protein, Mouse, Recombinant (His & hFc)

Cat.No: TMPY-01097

Species: Mouse

Expression System: HEK293 Cells

SR-BI/SCARB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05498

Species: Human

Expression System: HEK293 Cells

OSCAR Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01092

Species: Human

Expression System: HEK293 Cells

DODA Protein, Amanita muscaria, Recombinant (His & Myc)

Cat.No: TMPH-00047

Species: Amanita muscaria

Expression System: E. coli

SCARB1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02061

Species: Human

Expression System: E. coli

SR-BI/SCARB1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01098

Species: Mouse

Expression System: HEK293 Cells

OSCAR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01117

Species: Mouse

Expression System: HEK293 Cells

RGMA Protein, Human, Recombinant (His)

Cat.No: TMPY-02525

Species: Human

Expression System: HEK293 Cells

Latent TGF beta 3 Protein, Human, Recombinant (His)

Cat.No: TMPK-00258

Species: Human

Expression System: HEK293 Cells

MCP-5 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04671

Species: Mouse

Expression System: P. pastoris (Yeast)

Latent TGF beta 3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00259

Species: Human

Expression System: HEK293 Cells

DPT Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01369

Species: Mouse

Expression System: HEK293 Cells

Activin A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01846

Species: Mouse

Expression System: HEK293 Cells

INHBB Protein, Human, Recombinant (His)

Cat.No: TMPY-01190

Species: Human

Expression System: HEK293 Cells

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