romk inhibitor

VU591 hydrochloride 是选择性的肾外髓钾通道抑制剂，IC50为 0.24 μM。

VU591 是选择性的肾外髓钾通道抑制剂，IC50为 0.24 μM。

BMS-986308 是一种选择性强且口服活性的肾外髓质钾 (ROMK) 通道抑制剂，对 ROMK 的选择性优于 hERG，可用于心力衰竭研究。

Psycholeine is isolated from the tropical plant Psychotria oleoides; exhibits somatostatin antagonistic activity on growth hormone secretion.

XAN35021, also known as ROMK inhibitor 25, or ROMK-IN-25, is a potent and selective ROMK inhibitor with improved pharmacokinetic properties. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

MK-8153 是一种选择性的、有效的、口服具有活力的肾外髓质钾通道 (ROMK) 抑制剂，作用于 ROMK EP (IC50: 5 μM) 和 hERG EP (IC50: 34 μM)。MK-8153 能够用作利尿剂。

ROMK-IN-32 是一种肾外髓质钾通道 (ROMK) 抑制剂 (IC50: 35 nM)，也能够抑制 hERG (IC50: 22 μM)。

MK-7145 is an inhibitor of ROMK(IC50 of 0.045 μM).

VU590 是一种具有高效性和中等选择性的肾外髓质钾 ROMK (Kir1.1) 抑制剂。VU590 抑制 Kir7.1，可调节子宫肌层收缩力和黑皮质素信号传导。

PF-06807656 is insensitive to the introduction of the N171D mutation in the ROMK conduction pore that greatly diminishes the activity of other small-molecule inhibitors. PF-06807656 is an effective ROMK inhibitor (Tl+ flux IC50 = 160 nM).