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Targets Recommended: Mitophagy Influenza Virus MEK Autophagy

2

抑制剂 & 化合物

7

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T6223 U0126-EtOH

U0126 Ethanol,U0126

Mitophagy; Influenza Virus; MEK; Autophagy Autophagy; MAPK; Microbiology/Virology
U0126-EtOH (U0126 Ethanol) 是一种非 ATP 竞争性的选择性MEK1和MEK2抑制剂,IC50分别为 72 nM 和 58 nM。U0126-EtOH 可抑制自噬和线粒体自噬。
T71837 HBX

Others Others
HBX is a deubiquitinase inhibitor. It inhibits HAdV type 5 (species C, HAdV-C5) replication and oncogenic transformation through inhibition of the cellular pro-viral factor ubiquitin-specific protease 7 (USP7). HBX also significantly inhibits virus genome replication and progeny release of all adenovirus types tested, with the exception of types 12 and 31, from tested species.

化合物

U0126-EtOH
Cat.No: T6223
Synonym: U0126 Ethanol,U0126
Target: Mitophagy, Influenza Virus, MEK, Autophagy
HBX
Cat.No: T71837
Synonym:
Target: Others
Cat. No. Product Name Species Expression System
TMPK-01251 L1R Protein, Monkeypox virus, Recombinant (His)

0

Monkeypox virus E. coli
L1R, a myristylated late gene product of vaccinia virus, is essential for formation of infectious intracellular mature virions (IMV). In its absence, only viral particles arrested at an immature stage are detected and no infectious progeny virus is produced.
TMPK-00972 PK-1/PROK1 Protein, Mouse, Recombinant (hFc)

PROK1,Mambakine,Prokineticin-1,EG-VEGF

Mouse HEK293 Cells
PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in regulating viral propagation. Electron microscopy revealed that pk-1 deletion affected the formation of normal nucleocapsids.PK-1 appears to phosphorylate some viral or cellular proteins that are essential for DNA packaging to regulate nucleocapsid assembly.
TMPH-00535 Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)

Nuclear antigen,Apoptosis regulator BHRF1,Early antigen prot...

EBV E. coli
Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell.
TMPH-00147 IBV (strain KB8523) Replicase polyprotein 1ab (His)

ORF1ab polyprotein,Replicase polyprotein 1ab,rep

IBV Baculovirus Insect Cells
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.; NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. IBV (strain KB8523) Replicase polyprotein 1ab (His) is expressed in Baculo...
TMPH-02396 Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) Z Protein (His)

RING finger protein Z,Z,Zinc-binding protein

LASV E. coli
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins in...
TMPH-00201 BK polyomavirus (BKPyV) VP2 Protein (His)

Minor capsid protein VP2,Minor structural protein VP2

BKPyV E. coli
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ...
TMPH-02365 JC polyomavirus (JCV) Minor capsid protein VP2 (His)

Minor capsid protein VP2,Minor structural protein VP2

JCPyV E. coli
Isoform VP2 is a structural protein that resides within the core of the capsid surrounded by 72 VP1 pentamers. Participates in host cell receptor binding together with VP1. Following virus endocytosis and trafficking to the endoplasmic reticulum, VP2 and VP3 form oligomers and integrate into the endoplasmic reticulum membrane. Heterooligomer VP2-VP3 may create a viroporin for transporting the viral genome across the endoplasmic reticulum membrane to the cytoplasm. Nuclear entry of the viral DNA ...

重组蛋白

L1R Protein, Monkeypox virus, Recombinant (His)
Cat.No: TMPK-01251
Species: Monkeypox virus
Expression System: E. coli
PK-1/PROK1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00972
Species: Mouse
Expression System: HEK293 Cells
Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)
Cat.No: TMPH-00535
Species: EBV
Expression System: E. coli
IBV (strain KB8523) Replicase polyprotein 1ab (His)
Cat.No: TMPH-00147
Species: IBV
Expression System: Baculovirus Insect Cells
Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) Z Protein (His)
Cat.No: TMPH-02396
Species: LASV
Expression System: E. coli
BK polyomavirus (BKPyV) VP2 Protein (His)
Cat.No: TMPH-00201
Species: BKPyV
Expression System: E. coli
JC polyomavirus (JCV) Minor capsid protein VP2 (His)
Cat.No: TMPH-02365
Species: JCPyV
Expression System: E. coli
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