|
TMPH-03764
|
YAP1 Protein, Human, Recombinant (His)
YAP1-2gamma,YAP2L,YAP65
|
Human
|
P. pastoris (Yeast)
|
|
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,... |
|
TMPH-02271
|
BTK Protein, Human, Recombinant (His)
BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine-protein kina...
|
Human
|
Baculovirus Insect Cells
|
|
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in... |
|
TMPY-04483
|
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...
|
Human
|
Baculovirus Insect Cells
|
|
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... |
|
TMPH-03458
|
STE11 Protein, S. cerevisiae, Recombinant
Serine/threonine-protein kinase STE11,STE11
|
Saccharomyces cerevisiae
|
E. coli
|
|
Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KSS1 kinases. STE11 Protein, S. cerevisiae, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.5 kDa and the accession number is P23561. |
|
TMPH-00639
|
Hygromycin-B 4-O-kinase Protein, E. coli, Recombinant (His)
Hygromycin B phosphotransferase,hph,Hygromycin-B kinase,Hygr...
|
E. coli
|
E. coli
|
|
The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin. |
|
TMPH-01531
|
IKBKB Protein, Human, Recombinant (His)
Serine/threonine protein kinase IKBKB,Nuclear factor NF-kapp...
|
Human
|
Baculovirus Insect Cells
|
|
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu... |
|
TMPH-01211
|
DGUOK Protein, Human, Recombinant (His & SUMO)
Deoxyguanosine kinase, mitochondrial,Deoxyadenosine kinase, ...
|
Human
|
E. coli
|
|
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents. |
|
TMPH-01532
|
IKBKB Protein, Human, Recombinant (E. coli, His)
Nuclear factor NF-kappa-B inhibitor kinase beta,Serine/threo...
|
Human
|
E. coli
|
|
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In tu... |
|
TMPY-04540
|
S6K1/RPS6KB1 Protein, Human, Recombinant (GST)
p70(S6K)-alpha,PS6K,p70-alpha,p70(S6K)-α,p70-α,p70 S6KA,S6K-...
|
Human
|
Baculovirus Insect Cells
|
|
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is disso... |
|
TMPH-02226
|
TEAD3 Protein, Human, Recombinant (His & SUMO)
DTEF-1,TEA domain family member 3,Transcriptional enhancer f...
|
Human
|
E. coli
|
|
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr... |
|
TMPH-02272
|
JAK1 Protein, Human, Recombinant (E. coli, His)
Tyrosine-protein kinase JAK1,JAK1,Janus kinase 1
|
Human
|
E. coli
|
|
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. |
|
TMPH-02225
|
TEAD2 Protein, Human, Recombinant (His & Myc)
TEA domain family member 2,Transcriptional enhancer factor T...
|
Human
|
E. coli
|
|
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr... |
|
TMPH-01642
|
MELK Protein, Human, Recombinant (His & Myc)
Protein kinase Eg3,Tyrosine-protein kinase MELK,Protein kina...
|
Human
|
E. coli
|
|
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. ... |
|
TMPH-02222
|
TEAD1 Protein, Human, Recombinant (His)
TEAD1,Transcriptional enhancer factor TEF-1,Transcription fa...
|
Human
|
E. coli
|
|
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr... |
|
TMPH-02273
|
JAK1 Protein, Human, Recombinant (His)
JAK1,Janus kinase 1,Tyrosine-protein kinase JAK1
|
Human
|
P. pastoris (Yeast)
|
|
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. |
|
TMPH-00379
|
MLCK Protein, Chicken, Recombinant (His & Myc & SUMO)
Mylk,Telokin,Myosin light chain kinase, smooth muscle
|
Chicken
|
E. coli
|
|
Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals. MLCK Protein, Chicken, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 52.9 kDa and the accession number is P11799. |
|
TMPH-02961
|
JAK1 Protein, Mouse, Recombinant (His)
Janus kinase 1,Jak1,Tyrosine-protein kinase JAK1
|
Mouse
|
E. coli
|
|
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. JAK1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession numb... |
|
TMPH-03712
|
Clp1 Protein, Xenopus laevis, Recombinant (His)
clp1,Pre-mRNA cleavage complex II protein Clp1,Polyadenylati...
|
Xenopus laevis
|
E. coli
|
|
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the... |
|
TMPY-03266
|
COL4A3BP Protein, Human, Recombinant (His & GST)
CERTL,GPBP,collagen, type IV, alpha 3 (Goodpasture antigen) ...
|
Human
|
Baculovirus Insect Cells
|
|
COL4A3BP is a member of the StarD2 subfamily. It contains a pleckstrin homology domain at its amino terminus and a START domain towards the end of the molecule. COL4A3BP has a lipid-binding domain that mediates intracellular trafficking of ceramide in a non-vesicular manner. One isoform of COL4A3BP is also involved in ceramide intracellular transport. COL4A3BP specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as t... |
|
TMPH-02876
|
RIPK1 Protein, Mouse, Recombinant (His)
Cell death protein RIP,Receptor-interacting protein 1,Ripk1,...
|
Mouse
|
E. coli
|
|
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i... |
|
TMPY-04260
|
p38 Protein, Human, Recombinant (His)
mitogen-activated protein kinase 14,CSPB1,PRKM14,RK,p38α,CSB...
|
Human
|
Baculovirus Insect Cells
|
|
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ... |
|
TMPK-00447
|
CD45 Protein, Human, Recombinant (aa 26-577, hFc)
CD45,CD45R,LCA,PTPRC,L-CA,T200,B220,GP180,LY5,EC 3.1.3.48
|
Human
|
HEK293 Cells
|
|
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (aa 26-577... |
|
TMPK-00423
|
CD45 Protein, Human, Recombinant (His & Avi)
CD45R,LY5,EC 3.1.3.48,B220,CD45,T200,L-CA,GP180,LCA,PTPRC
|
Human
|
HEK293 Cells
|
|
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi... |
|
TMPY-04565
|
SRPK3 Protein, Human, Recombinant (His & GST)
MSSK1,MGC102944,STK23,MSSK-1,SRSF protein kinase 3
|
Human
|
Baculovirus Insect Cells
|
|
Serine / threonine-protein kinase SRPK3, also known as Muscle-specific serine kinase 1, Serine/arginine-rich protein-specific kinase 3, SR-protein-specific kinase 3, Serine / threonine-protein kinase 23, MSSK-1, SRPK3 and MSSK1, is a member of the protein kinase superfamily and CMGC Ser / Thr protein kinase family. SRPK3 is a protein kinase belonging to serine/arginine protein kinases (SRPK) family, which phosphorylates serine / arginine repeat-containing proteins, and is controlled by a muscle-... |
|
TMPK-00424
|
CD45 Protein, Human, Recombinant (His & Avi), Biotinylated
LCA,LY5,EC 3.1.3.48,CD45,L-CA,T200,CD45R,PTPRC,B220,GP180
|
Human
|
HEK293 Cells
|
|
PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. CD45 Protein, Human, Recombinant (His & Avi... |
|
TMPH-03586
|
Toxin zeta Protein, S. agalactiae, Recombinant (His)
Toxin zeta,UDP-N-acetylglucosamine kinase
|
Streptococcus agalactiae
|
P. pastoris (Yeast)
|
|
Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates UDP-N-acetyl-D-glucosamine (UNAG) on the 3'-hydroxyl group of the N-acetyl-D-glucosamine moiety, yielding UNAG-3P. UNAG-3P inhibits MurA, the first committed step in cell wall synthesis, which is then blocked. Phosphorylation is inhibited by cognate epsilon antitoxin. Part of a postsegregational killing (PSK) system involved in the killing of plasmid-free cells. The zeta toxin induces programmed cell death. Toxin zeta Prote... |
|
TMPH-02275
|
Lck Protein, Human, Recombinant (His)
Proto-oncogene Lck,T cell-specific protein-tyrosine kinase,T...
|
Human
|
E. coli
|
|
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules... |
|
TMPH-02540
|
GRK2 Protein, Mouse, Recombinant (His & SUMO)
Beta-adrenergic receptor kinase 1,Grk2,G-protein-coupled rec...
|
Mouse
|
E. coli
|
|
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and... |
|
TMPH-01539
|
ILK Protein, Human, Recombinant (His)
ILK-1,ILK,Integrin-linked protein kinase,59 kDa serine/threo...
|
Human
|
Baculovirus Insect Cells
|
|
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. P... |
|
TMPH-02173
|
TRBC2 Protein, Human, Recombinant (His & Myc)
T cell receptor beta constant 2,TRBC2
|
Human
|
E. coli
|
|
Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell... |
|
TMPH-02168
|
TRAC Protein, Human, Recombinant (E. coli, His)
T cell receptor alpha chain constant,TRAC
|
Human
|
E. coli
|
|
Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracel... |
|
TMPH-02169
|
TRBC1 Protein, Human, Recombinant (His)
T cell receptor beta constant 1,TRBC1
|
Human
|
P. pastoris (Yeast)
|
|
Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracell... |
|
TMPH-00743
|
PhoP Protein, E. coli, Recombinant (HEK293, His & Myc)
Transcriptional regulatory protein PhoP,phoP
|
E. coli
|
HEK293 Cells
|
|
Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG. Mediates magnesium influx to the cytosol by activation o... |
|
TMPY-04375
|
Casein Kinase 1 alpha Protein, Human, Recombinant (GST)
CKIa,casein kinase 1, alpha 1,casein kinase 1, α1,CK1a,Casei...
|
Human
|
Baculovirus Insect Cells
|
|
Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use... |
|
TMPH-01297
|
DDR1 Protein, Human, Recombinant (aa 21-417, His)
EDDR1,MCK-10,Epithelial discoidin domain-containing receptor...
|
Human
|
HEK293 Cells
|
|
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell... |
|
TMPY-04409
|
GRK6 Protein, Human, Recombinant (His & GST)
G protein-coupled receptor kinase 6,GPRK6
|
Human
|
Baculovirus Insect Cells
|
|
G protein-coupled receptor kinase 6, also known as G protein-coupled receptor kinase GRK6, GRK6, and GPRK6, is a lipid-anchor protein that belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRK6 / GPRK6 contains one AGC-kinase C-terminal domain, one protein kinase domain, and one RGS domain. This protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding differen... |
|
TMPH-02274
|
JAK2 Protein, Human, Recombinant (His)
JAK2,Janus kinase 2,Tyrosine-protein kinase JAK2
|
Human
|
E. coli
|
|
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int... |
|
TMPY-04547
|
PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK
|
Human
|
Baculovirus Insect Cells
|
|
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... |
|
TMPY-04567
|
SRPK1 Protein, Human, Recombinant (His & GST)
SRSF protein kinase 1,SFRSK1,RP3-422H11.1
|
Human
|
Baculovirus Insect Cells
|
|
Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the protein kinase superfamily and CMGC Ser/Thr protein kinase family. Isoform 2 of SRPK1 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 of SRPK1 is only seen in th... |
|
TMPY-04385
|
ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)
death-associated protein kinase 3,DLK,ZIP,ZIPK
|
Human
|
Baculovirus Insect Cells
|
|
Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with AT... |
|
TMPY-04555
|
GRK5 Protein, Human, Recombinant (His)
G protein-coupled receptor kinase 5,GPRK5
|
Human
|
Baculovirus Insect Cells
|
|
G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRKs specifically phosphorylate agonist-occupied G protein-coupled receptors at the inner surface of the plasma membrane (PM), leading to receptor desensitization. GRKs utilize a variety of mechanisms to bind tightly, and sometimes reversibly, to cellular membranes. GRKs play an important role in ... |
|
TMPY-01769
|
4EBP1 Protein, Human, Recombinant (His)
4E-BP1,eukaryotic translation initiation factor 4E binding p...
|
Human
|
E. coli
|
|
The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, a... |
|
TMPH-03753
|
MYLK Protein, Human, Recombinant (His)
MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase...
|
Human
|
E. coli
|
|
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl... |
|
TMPY-04542
|
CDK2 Protein, Human, Recombinant (His)
CDKN2,cyclin-dependent kinase 2,p33(CDK2)
|
Human
|
Baculovirus Insect Cells
|
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CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c... |
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