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Search Results for " neurotrophin "

Targets Recommended: Others

9

抑制剂 & 化合物

1

天然产物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11861	LM11A-31 dihydrochloride	Others	Others
	LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。它是一种 p75NTR(神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。它可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。
T4496	LM22B-10 LM22B10	ERK; Trk receptor; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	LM22B-10 是TrkB/TrkC 神经营养因子受体激活剂，诱导体内外TrkB、TrkC、AKT 和ERK 的活化。
T73397	ENT-C225	Trk receptor	Tyrosine Kinase/Adaptors
	ENT-C225 是一种高效的 TrkB 神经营养素受体（TrkBR）激活剂，具有神经保护活性，可用于研究阿尔茨海默病和帕金森病。
TP2069	BDNF (human)
	Member of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and A
T24268	KP-544 KP 544	Others	Others
	KP-544 is an agent of neurotrophin potentiator.
TP2278	NTR 368	Others	Others
	cytoplasmic peptide of the neurotrophin receptor p75NTR
T76813	Bedinvetmab
	Bedinvetmab (ZTS-00508841)为针对神经生长因子(NGF)的犬单克隆抗体(mAb)，通过抑制NGF与肌球蛋白原受体激酶A(trkA)及p75神经营养蛋白受体(p75NTR)的相互作用，应用于犬骨关节炎疼痛的研究。
T74097	THX-B	Others	Others
	THX-B为一高效非多肽类p75NTR（神经营养蛋白受体p75）拮抗剂，适用于糖尿病、肾病、神经退行性及炎症性疾病研究。
T75831	NTR 368 TFA
	NTR 368 TFA, 衍生自p75神经营养蛋白受体(p75NTR)，对应人类受体残基368-381，胶束脂质存在促使其倾向形成螺旋结构。该肽为神经细胞凋亡(apoptosis)的有效诱导剂。

化合物

LM11A-31 dihydrochloride

Cat.No: T11861

Target: Others

Cat.No: T4496

Synonym: LM22B10

Target: ERK, Trk receptor, Akt

Cat.No: T73397

Target: Trk receptor

Cat.No: TP2069

Cat.No: T24268

Synonym: KP 544

Target: Others

Cat.No: TP2278

Target: Others

Cat.No: T76813

Cat.No: T74097

Target: Others

Cat.No: T75831

Cat. No.	Product Name	Target	Signaling Pathways
T82339	Gangliotetraose Gg4
	Gangliotetraose（Gg4）是一种含有GM1及其唾液酸化衍生物的四糖。它能促进分化神经元核内Ca2+的外流，进而降低核内Ca2+浓度。Gg4参与调节神经元的可塑性、修复过程以及大脑中神经营养素的释放。

天然产物

Gangliotetraose

Cat.No: T82339

Synonym: Gg4

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04069	Neurotrophin 3 Protein, Human, Recombinant NGF2,HDNF,NT-3,neurotrophin 3,NGF-2,NT3	Human	E. coli
	NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. NTF3 is a key mediator of neuronal development during the early neurogenic period. NTF3 is a novel target gene of POU3F2 and that the POU3F2/NTF3 pathway plays a role in the process of neuronal differentiation. ...
TMPH-03341	Neurotrophin 3 Protein, Rat, Recombinant (His & Myc) Neurotrophin-3,Neurotrophic factor,Nerve growth fac...	Rat	E. coli
	Seems to promote the survival of visceral and proprioceptive sensory neurons. Neurotrophin 3 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 21.1 kDa and the accession number is P18280.
TMPH-01769	Neurotrophin 3 Protein, Human, Recombinant (His) NTF3,HDNF,Neurotrophic factor,Neurotrophin-3,Nerve ...	Human	E. coli
	Seems to promote the survival of visceral and proprioceptive sensory neurons. Neurotrophin 3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.7 kDa and the accession number is P20783.
TMPY-05804	NT-4 Protein, Human, Recombinant GLC10,NT-4/5,NT4,GLC1O,NT-5,NT5,neurotrophin 4,NT-4...	Human	E. coli
	NT-4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.93 kDa and the accession number is A0A024QZE4.
TMPJ-01469	NGF Protein, Human, Recombinant (E. colli) NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-Nerve Growt...	Mouse	E. coli
	NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo...
TMPJ-01468	pro-Beta NGF Protein, Human, Recombinant β-NGF,NGF,NGFB,Beta-NGF,Beta-Nerve Growth Factor,pro-Beta NG...	Human	E. coli
	The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite biological effects. ProNGF functions preferentially via the complex of pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin inducing neuronal apoptosis and contributing to age- and disease-related neurodegeneration.
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant BDNF,Abrineurin,Brain-Derived Neurotrophic Factor	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ...
TMPH-03224	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His) G,Glycoprotein	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03220	Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO) Glycoprotein,G	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03219	Rabies virus (RABV) (strain India) Glycoprotein (His) Glycoprotein,G	RABV	P. pastoris (Yeast)
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03223	Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His) G,Glycoprotein	RABV	Baculovirus Insect Cells
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPH-03221	Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO) G,Glycoprotein	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPJ-00134	pro-BDNF Protein, Human, Recombinant Brain-Derived Neurotrophic Factor,Abrineurin,BDNF	Human	E. coli
	The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regul...
TMPH-03222	Rabies virus (RABV) (strain ERA) Glycoprotein (His) Glycoprotein,G	RABV	E. coli
	Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabie...
TMPY-02484	SLITRK4 Protein, Human, Recombinant (His) DKFZp547M2010,SLIT and NTRK like family member 4	Human	HEK293 Cells
	SLIT and NTRK-like family proteins 4 is a member of the SLIT and NTRK-like family. This protein is characterized as an integral membrane protein that has two leucine-rich repeat (LRR) domains and a carboxy-terminal domain that is partially similar to SLIT protein and TRK Neurotrophin There are six members in this family: SLITRK1, SLITRK2, SLITRK3, SLITRK4, SLITRK5, and SLITRK6. Their expression was detected mainly in the brain, but the expression profile of each SLITRK was unique. Each of these ...

重组蛋白

Neurotrophin 3 Protein, Human, Recombinant

Cat.No: TMPY-04069

Species: Human

Expression System: E. coli

Neurotrophin 3 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03341

Species: Rat

Expression System: E. coli

Neurotrophin 3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01769

Species: Human

Expression System: E. coli

NT-4 Protein, Human, Recombinant

Cat.No: TMPY-05804

Species: Human

Expression System: E. coli

NGF Protein, Human, Recombinant (E. colli)

Cat.No: TMPJ-01469

Species: Mouse

Expression System: E. coli

pro-Beta NGF Protein, Human, Recombinant

Cat.No: TMPJ-01468

Species: Human

Expression System: E. coli

BDNF Protein, Human/Murine/Rat, Recombinant

Cat.No: TMPJ-00135

Species: Human,Mouse,Rat

Expression System: E. coli

Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His)

Cat.No: TMPH-03224

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO)

Cat.No: TMPH-03220

Species: RABV

Expression System: E. coli

Rabies virus (RABV) (strain India) Glycoprotein (His)

Cat.No: TMPH-03219

Species: RABV

Expression System: P. pastoris (Yeast)

Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His)

Cat.No: TMPH-03223

Species: RABV

Expression System: Baculovirus Insect Cells

Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO)

Cat.No: TMPH-03221

Species: RABV

Expression System: E. coli

pro-BDNF Protein, Human, Recombinant

Cat.No: TMPJ-00134

Species: Human

Expression System: E. coli

Rabies virus (RABV) (strain ERA) Glycoprotein (His)

Cat.No: TMPH-03222

Species: RABV

Expression System: E. coli

SLITRK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-02484

Species: Human

Expression System: HEK293 Cells

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