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Search Results for " nascent "

Targets Recommended: Nucleoside Antimetabolite/Analog

9

抑制剂 & 化合物

1

天然产物

19

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T36971	5-Ethynyluridine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	5-Ethynyluridine 可用于标记新合成的 RNA。这种方法称为使用点击化学 (RICK) 捕获新转录的 RNA 相互作用组，系统地捕获与多种 RNA 结合的蛋白质，包括新生 RNA 和传统上被忽视的非多腺苷酸化 RNA。
T31932	GJ071 oxalate GJ 071,GJ-071,GJ071	Others	Others
	GJ071 oxalate 是一种无义抑制剂。无义抑制剂（NonSups）诱导“读出”，即在提前终止密码子处选择近同源tRNA，并将相应的氨基酸插入新生多肽中。
T35648	4-Thiouridine	Others	Others
	4-Thiouridine (4-TU) 是一种光活化核糖核苷类似物，广泛用于RNA 分析。
T35306	Z-Hpg	Others	Others
	Z-Hpg is a novel bortac-gj enabled selective probe for labeling of nascent proteomes, thus recording translation, in cell networks connected by gap junctions, leaving unconnected cells not labeled
T24693	QD325 QD 325,QD-325	Others	Others
	QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in the nucleus, endoplasmic reticulum, and mitochondria of pancreatic ca
T31933	GJ072 GJ-072,GJ 072	Others	Others
	GJ-072 is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent polypeptide.
T80402	Api137
	Api137是一种抗生肽，其作用机制为通过抑制翻译干预细菌生长。具体来说，Api137在新生多肽链水解后，通过俘获释放因子于70S核糖体，从而抑制了蛋白质的合成。
T37432	Erythromycin A N-oxide	Others	Others
	Erythromycin A N-oxide is a potential impurity found in commercial preparations of erythromycin. Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains. It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s = 0.015-2.0 mg/l). Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can af...
T37433	Erythromycin lactobionate	Others	Others
	Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains.[1] It is effective against a host of bacterial genera, including Streptococcus, Staphylococcus, and Haemophilus (MIC90s range from 0.015-2.0 mg/l).[2] Erythromycin is known to potently inhibit the cytochrome P450 isoform CYP3A4, which can affect the metabolism of numerous clinically relevant medications.[3],[4] Erythromyc...

化合物

5-Ethynyluridine

Cat.No: T36971

Target: Nucleoside Antimetabolite/Analog

Cat.No: T31932

Synonym: GJ 071,GJ-071,GJ071

Target: Others

Cat.No: T35648

Target: Others

Cat.No: T35306

Target: Others

Cat.No: T24693

Synonym: QD 325,QD-325

Target: Others

Cat.No: T31933

Synonym: GJ-072,GJ 072

Target: Others

Cat.No: T80402

Erythromycin A N-oxide

Cat.No: T37432

Target: Others

Erythromycin lactobionate

Cat.No: T37433

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6272	Fosbretabulin Disodium Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Fosbretabulin Disodium (CA 4P) 是一种微管蛋白去稳定剂，是 Combretastatin A4 前药，可选择性靶向内皮细胞，诱导新生肿瘤新血管消退，减少肿瘤血流量并引起中央肿瘤坏死。

天然产物

Fosbretabulin Disodium

Cat.No: T6272

Synonym: Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium

Target: Apoptosis, Microtubule Associated

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02110	SEC11C Protein, Human, Recombinant (His & SUMO) Microsomal signal peptidase 21 kDa subunit,SEC11-like protei...	Human	E. coli
	Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
TMPH-00654	Methionine aminopeptidase Protein, E. coli, Recombinant (His & SUMO) Methionine aminopeptidase,map,Peptidase M	E. coli	E. coli
	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
TMPJ-01395	NIP7 Protein, Human, Recombinant (His) KD93,NIP7,60S Ribosome Subunit Biogenesis Protein NIP7 Homol...	Human	E. coli
	60S Ribosome Subunit Biogenesis Protein NIP7 Homolog (NIP7) belongs to the NIP7 family. NIP7 contains one PUA domain, it is essential for the process of proper 27S pre-rRNA and 60S ribosome subunit assembly. NIP7 is a monomer form and interacts with NOL8 and SBDS, and may bind to RNA. In addition, NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are export...
TMPH-03029	MetAP Protein, Mycoplasma pneumoniae, Recombinant (His & SUMO) Peptidase M,Methionine aminopeptidase,map	Mycoplasma pneumoniae	E. coli
	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
TMPH-03714	HAS1 Protein, Xenopus tropicalis, Recombinant (His & Myc) Hyaluronic acid synthase 1,has1,Hyaluronan synthase 1,Hyalur...	Xenopus tropicalis	E. coli
	Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.
TMPH-00741	Rho Protein, E. coli, Recombinant (His) Transcription termination factor Rho,ATP-dependent helicase ...	E. coli	E. coli
	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. RNA-dependent NTPase which utilizes all four ribonucleoside triphosphates as substrates. Rho Protein, E. coli, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 51.0 kDa and the accession number is P0AG30.
TMPY-04073	MRPL44 Protein, Human, Recombinant (His) mitochondrial ribosomal protein L44,COXPD16,L44MT,MRP-L44	Human	Baculovirus Insect Cells
	MRPL44 (Mitochondrial Ribosomal Protein L44) is a Protein Coding gene. MRPL44 encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate near the tunnel exit of the yeast mitochondrial ribosome. It belongs to the mitochondrion-specific ribosomal protein mL44 subfamily. In the patient fibroblasts, decreased MRPL44 affected assembly of the large ribosomal subunit and stability of 16S rRNA leading to complex IV deficiency. It may have a function in the assembly/...
TMPH-03018	MeTAP1 Protein, Mycobacterium tuberculosis, Recombinant (His) Peptidase M,map-1,Methionine aminopeptidase 1	Mycobacterium tuberculosis	E. coli
	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. MeTAP1 Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 32.9 kDa and the accession ...
TMPH-01463	HNRNPL Protein, Human, Recombinant (His & SUMO) HNRNPL,Heterogeneous nuclear ribonucleoprotein L	Human	E. coli
	Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. HNRNPL Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6x...
TMPH-03404	Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) S4,Outer capsid protein sigma-3	Reo-3	E. coli
	Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding.; The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3. Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) is expr...
TMPY-03444	PFDN4 Protein, Human, Recombinant (His) PFD4,prefoldin subunit 4,C1	Human	E. coli
	PFDN4 is a member of the prefoldin beta subunit family. It is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. PFDN4 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. PFDN4 also binds to nascent polypeptide chain and ...
TMPY-03396	PFDN2 Protein, Human, Recombinant (His) PFD2,prefoldin subunit 2	Human	E. coli
	PFD2, also known as PFDN2, belongs to the prefoldin beta subunit family. PFD2 is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. PFD2 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. PFD2 also binds to a nascent pol...
TMPJ-00247	METAP1 Protein, Human, Recombinant METAP1,Methionine aminopeptidase 1,MAP 1,MetAP 1,Peptidase M...	Human	E. coli
	Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine...
TMPY-03870	EDEM2 Protein, Human, Recombinant (His) UNQ573/PRO1135,ER degradation enhancer, mannosidase alpha-li...	Human	HEK293 Cells
	EDEM2, also known as C2orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome. Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal. In humans there are a total of three EDEM ...
TMPY-00517	LSP1 Protein, Human, Recombinant (His) lymphocyte-specific protein 1,WP34,pp52	Human	HEK293 Cells
	LSP1 (Lymphocyte Specific Protein 1) is a Protein Coding gene. This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. LSP1 is a lymphocyte-specific intracellular Ca2(+)-binding protein. LSP1 localizes to nascent phagocytic cups during Fcgamma receptor-mediated phagocytosis, where it displays the same ...
TMPY-01344	MAP1D Protein, Human, Recombinant (His) MetAP 1D,Metap1l,MAP 1D,methionyl aminopeptidase type 1D (mi...	Human	Baculovirus Insect Cells
	Methionine aminopeptidase 1D, also known as MAP1D, is a member of the peptidase M24A family. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. The enzymes that catalyze this reaction are called Methionine aminopeptidases (MAPs). MAP1D is overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level). Downregulation of MAP1D express...
TMPH-02186	TERT Protein, Human, Recombinant (His) Telomerase reverse transcriptase,Telomerase catalytic subuni...	Human	E. coli
	Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de...
TMPY-02050	DDOST Protein, Human, Recombinant CDG1R,OST48,OKSWcl45,AGER1,OST,dolichyl-diphosphooligosaccha...	Human	E. coli
	The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST/OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto...
TMPY-02217	HSC70 Protein, Human, Recombinant (His) HSP73,HSC54,HSP71,NIP71,LAP-1,HEL-33,HSPA10,HSC71,LAP1,HEL-S...	Human	E. coli
	HSPA8, also known as HSC70, is a member of the heat shock protein family due to homology with other heat shock proteins. The heat shock protein 70 family is comprised of both heat-inducible and constitutively expressed members. The latter are called heat-shock cognate proteins. HSPA8 belongs to the heat-shock cognate subgroup. Members of the human heat-shock protein multigene family have several highly conserved proteins with structural and functional properties in common but vary in the extent ...

重组蛋白

SEC11C Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02110

Species: Human

Expression System: E. coli

Methionine aminopeptidase Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00654

Species: E. coli

Expression System: E. coli

NIP7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01395

Species: Human

Expression System: E. coli

MetAP Protein, Mycoplasma pneumoniae, Recombinant (His & SUMO)

Cat.No: TMPH-03029

Species: Mycoplasma pneumoniae

Expression System: E. coli

HAS1 Protein, Xenopus tropicalis, Recombinant (His & Myc)

Cat.No: TMPH-03714

Species: Xenopus tropicalis

Expression System: E. coli

Rho Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00741

Species: E. coli

Expression System: E. coli

MRPL44 Protein, Human, Recombinant (His)

Cat.No: TMPY-04073

Species: Human

Expression System: Baculovirus Insect Cells

MeTAP1 Protein, Mycobacterium tuberculosis, Recombinant (His)

Cat.No: TMPH-03018

Species: Mycobacterium tuberculosis

Expression System: E. coli

HNRNPL Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01463

Species: Human

Expression System: E. coli

Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)

Cat.No: TMPH-03404

Species: Reo-3

Expression System: E. coli

PFDN4 Protein, Human, Recombinant (His)

Cat.No: TMPY-03444

Species: Human

Expression System: E. coli

PFDN2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03396

Species: Human

Expression System: E. coli

METAP1 Protein, Human, Recombinant

Cat.No: TMPJ-00247

Species: Human

Expression System: E. coli

EDEM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-03870

Species: Human

Expression System: HEK293 Cells

LSP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00517

Species: Human

Expression System: HEK293 Cells

MAP1D Protein, Human, Recombinant (His)

Cat.No: TMPY-01344

Species: Human

Expression System: Baculovirus Insect Cells

TERT Protein, Human, Recombinant (His)

Cat.No: TMPH-02186

Species: Human

Expression System: E. coli

DDOST Protein, Human, Recombinant

Cat.No: TMPY-02050

Species: Human

Expression System: E. coli

HSC70 Protein, Human, Recombinant (His)

Cat.No: TMPY-02217

Species: Human

Expression System: E. coli

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