mk 1775

MK-1775 hemihydrate is a WEE1 inhibitor with potential antineoplastic sensitizing activity.

Adavosertib (MK-1775) 是一种细胞周期调节蛋白 Wee1 的抑制剂 (IC50=5.2 nM)，具有选择性。Adavosertib 具有抗肿瘤活性，可以阻滞细胞周期，抑制肿瘤细胞增殖。

Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.