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Search Results for " magnitude "

Targets Recommended: Adenosine Receptor

7

抑制剂 & 化合物

2

天然产物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16136	MRS-1706	Adenosine Receptor	GPCR/G Protein; Neuroscience
	MRS-1706 是一种选择性A2B 腺苷受体的反向激动剂，对人 A2B、A2A、A1和 A3受体的Ki 值分别为 1.39、112、157 和 230 nM。
T2119	Venetoclax GDC-0199,ABT 199,维奈妥拉,ABT-199,ABT199	BCL; Autophagy	Apoptosis; Autophagy
	Venetoclax (ABT-199) 是一种 Bcl-2 抑制剂 (Ki<0.01 nM)，具有高效性、选择性和口服活性。Venetoclax 与 Bcl-xL 和 Bcl-W 的亲和力降低了 3 个数量级（Kis=48/245 nM）。Venetoclax 可以诱导自噬和凋亡。
T71191	Covidcil-19	Others	Others
	Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.
TP1680	ProTx II
	Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
T71147	PBS-1086	Others	Others
	PBS-1086 is a novel dual inhibitor of the canonical and noncanonical NF-κB pathways, increasing the magnitude and duration of initial EGFR inhibitor response in multiple NSCLC models, decreasing PDHK1 expression, and suppressing phosphorylation of the PDHK1 protein substrate PDHA1 in a panel of PTEN-deficient cell lines.
T37629	IDFP	Others	Others
	The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) hydrolyze 2-AG and AEA, respectively, thus terminating their biological function. IDFP is an organophosphorus compound that dually inhibits MAGL and F...
TP2176	amyloid A protein fragment [Homo sapiens]	Others	Others
	Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH) are a family of apolipoproteins associated with high-density lipoprotein in plasma. Different isoforms of SAA are expressed constitutively at different levels or in response to inflammatory stimuli.

化合物

Cat.No: T16136

Target: Adenosine Receptor

Cat.No: T2119

Synonym: GDC-0199,ABT 199,维奈妥拉,ABT-199,ABT199

Target: BCL, Autophagy

Cat.No: T71191

Target: Others

Cat.No: TP1680

Cat.No: T71147

Target: Others

Cat.No: T37629

Target: Others

amyloid A protein fragment [Homo sapiens]

Cat.No: TP2176

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5S1172	Tiliroside 银椴甙,Tribuloside,银椴苷；椴树苷	Antioxidant	oxidation-reduction
	Tiliroside (Tribuloside) 是糖苷类黄酮，是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收，具有抗糖尿病作用。
T8098	γ-Hexalactone γ-caprolactone,gamma-己内酯,γ-己内酯	Others	Others
	γ-Hexalactone (γ-caprolactone) 是一种存在成熟水果中的 gamma 内酯。它会导致 DNA 损伤，可用作对氧磷酶 1 的底物 (PON1)。

天然产物

Cat.No: T5S1172

Synonym: 银椴甙,Tribuloside,银椴苷；椴树苷

Target: Antioxidant

Cat.No: T8098

Synonym: γ-caprolactone,gamma-己内酯,γ-己内酯

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01246	GDF-15 Protein, Mouse, Recombinant (His) MIC1,Placental TGF-beta,Placental TGF-β,PTGF-beta,PTGFBPTGF-...	Mouse	E. coli
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec...
TMPK-00589	Apolipoprotein E/APOE4 Protein, Human, Recombinant (His) APOE,apolipo E,Apo-E,APOE4,Apolipoprotein E	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells w...
TMPK-00788	Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc) apolipo E,Apo-E,Apolipoprotein E,APOE	Mouse	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells wi...
TMPK-00763	Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated APOE3,Apo-E,apolipo E,Apolipoprotein E,APOE	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated i...
TMPK-00665	GDF-15 Protein, Cynomolgus, Recombinant (His) PTGFBPTGF-beta,PTGFBPTGF-β,MIC-1,NAG-1,MIC1,PTGF-beta,PTGF-β...	Cynomolgus	E. coli
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus...
TMPK-00588	Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc) Apolipoprotein E,Apo-E,apolipo E,APOE4,APOE	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w...
TMPK-00663	GDF-15 Protein, Cynomolgus, Recombinant (hFc) PTGF-β,GDF-15,NAG-1,PTGF-beta,PDF,PTGFBPTGF-beta,GDF15,Place...	Cynomolgus	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus...
TMPK-00664	GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated Placental TGF-beta,PTGFBPTGF-β,PLAB,MIC-1,GDF15,NAG-1,RG-1,P...	Cynomolgus	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPK-00198	GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated MIC-1,PTGFBPTGF-β,GDF15,PTGF-β,GDF-15,PTGF-beta,Placental TG...	Human	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPK-00762	Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc) APOE,Apo-E,Apolipoprotein E,APOE3,apolipo E	Human	HEK293 Cells
	Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to support membrane homeostasis and injury repair in the brain. Considering prevalence and relative risk magnitude, the ε4 allele of the APOE gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD). Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells w...
TMPK-01244	GDF-15 Protein, Mouse, Recombinant (hFc) PTGFBPTGF-beta,PTGFB,PLAB,NAG-1,Placental TGF-β,RG-1,GDF15,G...	Mouse	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec...
TMPK-01245	GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated RG-1,GDF15,Placental TGF-beta,GDF-15,PTGFBPTGF-beta,NAG-1,PT...	Mouse	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPK-00197	GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated Placental TGF-β,GDF15,RG-1,MIC-1,PTGFB,PTGF-beta,PDF,PTGF-β,...	Human	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...

重组蛋白

GDF-15 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01246

Species: Mouse

Expression System: E. coli

Apolipoprotein E/APOE4 Protein, Human, Recombinant (His)

Cat.No: TMPK-00589

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00788

Species: Mouse

Expression System: HEK293 Cells

Apolipoprotein E/APOE3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00763

Species: Human

Expression System: HEK293 Cells

GDF-15 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00665

Species: Cynomolgus

Expression System: E. coli

Apolipoprotein E/APOE4 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00588

Species: Human

Expression System: HEK293 Cells

GDF-15 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPK-00663

Species: Cynomolgus

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00664

Species: Cynomolgus

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00198

Species: Human

Expression System: HEK293 Cells

Apolipoprotein E/APOE3 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00762

Species: Human

Expression System: HEK293 Cells

GDF-15 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01244

Species: Mouse

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated

Cat.No: TMPK-01245

Species: Mouse

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated

Cat.No: TMPK-00197

Species: Human

Expression System: HEK293 Cells

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