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Targets Recommended: Glucocorticoid Receptor AhR Calcium Channel Autophagy

6

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T0343 Nimodipine

尼莫地平,BAY-e 9736

Glucocorticoid Receptor; AhR; Calcium Channel; Autophagy Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
Nimodipine (BAY-e 9736) 是一种具有口服活性,耐受性良好的光敏二氢吡啶钙拮抗剂。它可研究脑血管疾病。
T14994 Coelenterazine h

腔肠素-H,2-Deoxycoelenterazine,CLZN-h

Others Others
Coelenterazine h (CLZN-h) 是一种 Coelenterazine 的衍生物。它对 Ca2+比它的天然复合物更敏感,是一种能够测量 Ca2+浓度的微小变化的有效工具。
T40889 DMNB-caged-Serine

Others Others
DMNB-caged-Serine is a photocaged amino acid . DMNB is a caging group which is sensitive to blue light. DMNB-caged-Serine can be incorporated into proteins in Saccharomyces cerevisiae in response to the amber nonsense codon TAG, which can be helpful for controlling the chemical composition of mammalian proteins..
T37698 OptoBI-1

Others Others
OptoBI-1 是一种光敏分子,是光致变色的TRPC3激动剂,可用作控制神经元放电的光药理学工具。
T24692 QAQ dichloride

Others Others
QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit this effect. This compound is membrane-impermeant and selectively enters pain-sensing neurons expressing endogenous import channels. QAQ dichloride functions as a light-sensitive analgesic and provides a valuable tool for investigating signaling mechanisms involved in acute and ...
TP2199 Rhodopsin peptide

Others Others
Rhodopsin peptide is a peptide with the sequence H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH, MW= 1217.33. Rhodopsin is a biological pigment in photoreceptor cells of the retina that is responsible for the first events in the perception of ligh

化合物

Nimodipine
Cat.No: T0343
Synonym: 尼莫地平,BAY-e 9736
Target: Glucocorticoid Receptor, AhR, Calcium Channel, Autophagy
Coelenterazine h
Cat.No: T14994
Synonym: 腔肠素-H,2-Deoxycoelenterazine,CLZN-h
Target: Others
DMNB-caged-Serine
Cat.No: T40889
Synonym:
Target: Others
OptoBI-1
Cat.No: T37698
Synonym:
Target: Others
QAQ dichloride
Cat.No: T24692
Synonym:
Target: Others
Rhodopsin peptide
Cat.No: TP2199
Synonym:
Target: Others
Cat. No. Product Name Target Signaling Pathways
T2850 Bicuculline

荷包牡丹碱,(+)-Bicuculline,d-Bicuculline

GABA Receptor Membrane transporter/Ion channel; Neuroscience
Bicuculline ((+)-Bicuculline) 是从东北延胡索中提取的一种生物碱,能阻断 Ca2+激活钾 (SK) 通道。它是一种竞争性的神经递质 GABAA 受体拮抗剂,IC50为 2 μM。

天然产物

Bicuculline
Cat.No: T2850
Synonym: 荷包牡丹碱,(+)-Bicuculline,d-Bicuculline
Target: GABA Receptor
Cat. No. Product Name Species Expression System
TMPY-02717 GPR37 Protein, Human, Recombinant (His)

hET(B)R-LP,PAELR,G protein-coupled receptor 37 (endothelin r...

Human HEK293 Cells
GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exist in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are bonded and activated by light-sensitive compounds, odors, pheromones, hormones, and n...
TMPH-03753 MYLK Protein, Human, Recombinant (His)

MYLK,Myosin light chain kinase, smooth muscle,Telok...

Human E. coli
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl...

重组蛋白

GPR37 Protein, Human, Recombinant (His)
Cat.No: TMPY-02717
Species: Human
Expression System: HEK293 Cells
MYLK Protein, Human, Recombinant (His)
Cat.No: TMPH-03753
Species: Human
Expression System: E. coli
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