lee011

Ribociclib (LEE011) 是一种细胞周期蛋白依赖性激酶 CDK4 6 抑制剂 (IC50=10 39 nM)，具有特异性和口服活性。Ribociclib 具有抗肿瘤活性，可以阻滞细胞周期，抑制肿瘤细胞增殖。

Ribociclib succinate (LEE011 succinate) 是一种高度特异性的CDK4 6抑制剂，IC50值分别为 10 nM 和 39 nM。它对细胞周期蛋白 B CDK1 复合物的效力低 1000 倍。

Ribociclib succinate hydrate is a highly specific CDK4 6 inhibitor (IC50s: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B CDK1 complex.

Ribociclib hydrochloride is a highly specific CDK4 6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B CDK1 complex.

Ribociclib-d6 是 Ribociclib 的氘代化合物。Ribociclib 的 CAS 号为 1211441-98-3。Ribociclib (LEE011) 是一种细胞周期蛋白依赖性激酶 CDK4 6 抑制剂 (IC50=10 39 nM)，具有特异性和口服活性。Ribociclib 具有抗肿瘤活性，可以阻滞细胞周期，抑制肿瘤细胞增殖。