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Search Results for " intestinal fluid "

Targets Recommended: CFTR Autophagy

抑制剂 & 化合物

天然产物

重组蛋白

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T2451	GlyH-101 GlyH 101	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	GlyH-101 是一种可渗透入细胞的 CFTR 阻断剂，Ki 为1.4 uM。
T81539	PAT1inh-B01	Others	Others
	PAT1inh-B01为选择性SLC26A6抑制剂，抑制PAT1（Cl-/HCO3-交换器）介导的阴离子交换（IC50: 350 nM），并阻断小肠液体吸收，适用于小肠分泌不足相关疾病研究。

化合物

GlyH-101

Cat.No: T2451

Synonym: GlyH 101

Target: CFTR, Autophagy

Cat. No.	Product Name	Target	Signaling Pathways
TN5147	Tilifodiolide	IL Receptor; TNF; GABA Receptor	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effects mediated by nitric oxide and cyclic guanosine monophosphate, it also showed anxiolytic and antidepressant effects by the partial involvement of gamma-Aminobutyric acid (GABA) receptors and the possible participation of α2-adrenoreceptors, respectively.

天然产物

Tilifodiolide

Cat.No: TN5147

Synonym:

Target: IL Receptor, TNF, GABA Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01388	GUCY2C Protein, Canine, Recombinant (aa 21-430, His) GC-C,GUCY2C,STAR,EC 4.6.1,STA receptor,GCC,MUCIL,Guanylyl cy...	Canine	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Canine, Recombinant (aa 21-430, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 47.6 kDa and the accession number is F1PAG3.
TMPK-00991	GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated EC 4.6.1,Guanylyl cyclase C,MUCIL,GUC2CEC 4.6.1.2,GUC2C,STA ...	Mouse	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.01 kDa and the accession number is Q3UWA6-1.
TMPH-01424	GUCA2B Protein, Human, Recombinant (His) Guanylate cyclase activator 2B,GUCA2B	Human	HEK293 Cells
	Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661.
TMPK-01279	GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His) GUC2CEC 4.6.1.2,GCC,Guanylyl cyclase C,STA receptor,MUCIL,GU...	Cynomolgus	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 47.2 kDa and the accession number is XP_005570270.1.
TMPK-00856	GUCY2C Protein, Human, Recombinant (His & Avi) GCC,STAR,STA receptor,Guanylyl cyclase C,EC 4.6.1,GUC2C,MUCI...	Human	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 48.8 kDa and the accession number is P25092-1.
TMPK-00990	GUCY2C Protein, Mouse, Recombinant (His & Avi) GC-C,STAR,DIAR6,GCC,GUC2CEC 4.6.1.2,STA receptor,MUCIL,GUCY2...	Mouse	HEK293 Cells
	Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. GUCY2C Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 50.01 kDa and the accession number is Q3UWA6-1.

重组蛋白

GUCY2C Protein, Canine, Recombinant (aa 21-430, His)

Cat.No: TMPK-01388

Species: Canine

Expression System: HEK293 Cells

GUCY2C Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00991

Species: Mouse

Expression System: HEK293 Cells

GUCA2B Protein, Human, Recombinant (His)

Cat.No: TMPH-01424

Species: Human

Expression System: HEK293 Cells

GUCY2C Protein, Cynomolgus, Recombinant (aa 24-430, His)

Cat.No: TMPK-01279

Species: Cynomolgus

Expression System: HEK293 Cells

GUCY2C Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00856

Species: Human

Expression System: HEK293 Cells

GUCY2C Protein, Mouse, Recombinant (His & Avi)

Cat.No: TMPK-00990

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71303	Flufenamic Acid-d4
	Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear...

同位素标记化合物

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抑制剂 & 化合物

天然产物

重组蛋白

同位素标记化合物

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化合物

天然产物

重组蛋白

同位素标记化合物