hynic-peg3-n3

Hynic-PEG3-N3 is a 3-unit PEG ADC linker, which is cleavable. It is commonly employed for the synthesis of antibody-drug conjugates (ADCs)[1].

AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.

Ansamitocin P 3' (Maytansinol butyrate) 是一种具有抗肿瘤活性的抗体-药物偶联细胞毒素。

Gefitinib-based PROTAC 3 通过 linker 将 EGFR 结合元件与 von Hippel-Lindau 配体结合，在 HCC827（外显子 19 del）和 H3255（L858R 突变）细胞中诱导 EGFR 降解，DC50 分别为 11.7 和 22.3 nM。

PROTACFLT-3degrader 4 是一种口服活性强的 CRBN 基于的 FLT3-PROTAC 降解剂，能够通过泛素-蛋白酶体系统有效降解 FLT3-ITD。此化合物对 FLT3-ITD 突变的急性髓性白血病 (AML) 细胞展现出高度选择性。

Aster-A Ligand-3 是 E3 ligase 的一种配体，可用于合成 PROTACAster-A 降解剂。

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH, also known as VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH, is a conjugate compound comprising a ligand-linker that targets E3 ligase and, on one end, features a VHL ligand. It is employed in PROTAC technology applications.

Methyl 1-Boc-azetidine-3-carboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66490，CAS号为 610791-05-4。

PROTACBcl-xL degrader-3 是一种有效的 PROTACBcl-xL 降解剂。

1-N-Boc-3-hydroxyazetidine 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67084，CAS号为 141699-55-0。

NHS-PEG4-(m-PEG12)3-ester is a polyethylene glycol (PEG) based linker for PROTAC synthesis [1].

Azido-PEG4-(CH2)3-methyl ester is a polyethylene glycol (PEG) based linker utilized in the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].

PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].

PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4.

DBCO-(PEG)3-VC-PAB-MMAE is a chemical compound where monomethyl auristatin E (MMAE), a potent tubulin inhibitor acting as a toxin payload in antibody-drug conjugates, is conjugated to a DBCO-(PEG)3-vc-PAB linker.

Biotin-PEG3-(CH2)3-NH2 TFA salt is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC ER Degrader-3, an intermediate for the synthesis of PAC, specifically compound LP2. PAC serves as the linker for ADCs and PROTACs that are conjugated to an antibody. Notably, when PAC is conjugated to an antibody, it exhibits enhanced degradation of estrogen receptor-alpha (ERα) compared to PROTAC alone [1].

Tri-GalNAc(OAc)3为一tri-GalNAc配体，用于GalNAc-LYTAC合成，该合成物通过靶向去唾液酸糖蛋白受体实施蛋白降解。

1-Cbz-azetidine-3-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66609，CAS号为 97628-92-7。

PROTACIRAK4 ligand-3 为 PROTACIRAK4 degrader-7 配体，适用于癌症研究领域。

PROTACBRD9 Degrader-3为BRD9靶向的双功能降解剂，用于癌症研究。

TSPO ligand-3为AUTAC2的配体，其中AUTAC2包含p-氟苄基鸟嘌呤(FBnG)及FKBP合成配体(SLF)两部分，能在HeLa细胞中显著沉默FKBP12蛋白。

4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-derived PROTAC linker employed for the synthesis of PROTACs[1].

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].

DOTA-(t-butyl)3-PEG5-azide is a polyethylene glycol (PEG) derived linker designed specifically for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

PROTAC CRABP-II Degrader-3 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on [cIAp1].

(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-derived PROTAC linker suitable for the synthesis of PROTACs[1].

PROTACSMARCA2 degrader-3(Compound 153)作为SWI SNF ATPase亚基SMARCA2的PROTAC降解剂，展现出抗癌活性。

PPM-3是一种高效的选择性PROTAC ERK5降解剂，不会直接作用于肿瘤细胞生长，而是通过调控巨噬细胞分化来间接影响肿瘤发展。

PROTACα-synuclein degrader 3 (compound 5) 为高效的选择性 PROTACα-synuclein 降解剂，适用于帕金森病研究。

N-Boc-PEG-t-butyl ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

1-Boc-azetidine-3-yl-methanol 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66497，CAS号为 142253-56-3。

PROTACBTK Degrader-3为BTKPROTAC降解剂，具有效力，其在Mino细胞中BTK降解的DC50值为10.9 nM。该降解剂具有应用于研究B细胞恶性肿瘤潜力，包括慢性淋巴细胞恶性肿瘤。

Pyrene azide 3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azetidin-3-ol hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66004，CAS号为 18621-18-6。

Azetidine-3-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66328，CAS号为 36476-78-5。

Fmoc-N-amido-PEG-CH2COOH (MW 3400) is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

Tri-GalNAc(OAc)3 TFA为一种tri-GalNAc配体，用于GalNAc-LYTAC合成，后者通过靶向去唾液酸糖蛋白受体实现蛋白降解。

Methyl 1-Cbz-azetidine-3-carboxylate为非可裂解型ADC连接器，适用于抗体药物偶联物(ADCs)的合成。同时，此化合物亦作为基于烷基链的PROTAC连接器，在PROTAC合成中发挥作用。

1H-Isoindole-1,3(2H)-dione, 4-(2-aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)- 在生命科学相关研究中具有广泛的应用。

LL-K9-3是一种基于选择性疏水标记技术（HyT）的CDK9-cyclin T1复合物降解剂（DC50值分别为cyclin T1的589 nM和CDK9的662 nM）。它由CDK9抑制剂SNS 032和一个糖基连接器连接到疏水标记组成。LL-K9-3不会降解其他CDKs（CDK1、2、4、5、6和7）。在22RV1细胞中，LL-K9-3通过诱导CDK9和cyclin T1的选择性和同步降解，降低雄激素受体（AR）和cMyc的表达。

3-Mercaptopropionic acid NHS ester 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64663。

Methyl 3-hydroxypropanoate is a PROTAC linker compound, which belongs to the alkyl ether family. It is commonly employed in the synthesis of PROTACs.

PROTACEGFRdegrader 3 是一种有效的 PROTACEGFR 降解剂。PROTACEGFRdegrader 3 对 H1975 和 HCC827 细胞具有优异的细胞活性和高选择性。PROTACEGFRdegrader 3 表明溶酶体参与了 EGFR 突变体的降解过程。

m-PEG2-O-Ph-3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.

PROTAC BET Degrader-3 is a potent degrader of BET proteins based on the PROTAC (PROteolysis TArgeting Chimera) technology.

PROTACSOS1 degrader-3 是一种有效的 PROTACSOS1降解剂。PROTACSOS1 degrader-3 通过泛素-蛋白酶体系统有效靶向 SOS1 进行降解。