首页工具

登录

搜索结果

Search Results for " human primary fibroblasts "

Targets Recommended: Others Reactive Oxygen Species

6

抑制剂 & 化合物

1

天然产物

5

重组蛋白

1

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T1684	Nitisinone 尼替西农,NTBC,SC0735,Nitisone	Others; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Others
	Nitisinone (SC0735) 是一种 4-羟基苯丙酮酸双加氧酶抑制剂。
T38293	4-CPPC	Others	Others
	4-CPPC 是一种巨噬细胞迁移抑制因子 2 (MIF-2; IC50= 27 μM) 的抑制剂。它对 MIF-2 的选择性高于 MIF-1 (IC50= 450 μM)。当以 10 μM 浓度使用时，它在体外抑制 MIF-2，但不抑制 MIF-1，与 CD74 结合。 4-CPPC（5、10 和 25 μM）抑制原代人皮肤成纤维细胞中 MIF-2 诱导的 ERK1/2 磷酸化。
T36073	S-Acetyl-L-glutathione	Others	Others
	S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases ...
T36003	1(R)-(Trifluoromethyl)oleyl alcohol	Others	Others
	1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 μM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 μM) reduces lipid peroxidation induced byFXNsiRNA knockdown in NBT human myoblasts. 1.Cotticelli, M.G., Forestieri, R., Xia, S., et ...
T82314	GK444	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	GK444（Compound 15a），一种针对HDAC1/2的抑制剂，IC50分别为HDAC1和HDAC2的100 nM与92 nM。其对Caco-2细胞的IC50为4.1μM，并能下调原代正常人肺成纤维细胞中TGF-β1刺激的COL1A1 mRNA水平。此外，GK444还能抑制博来霉素诱发的小鼠肺纤维化。
T83879	1-Arachidoyl Lysophosphatidic Acid sodium 1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid
	1-花生四烯酰基溶血磷脂酸（1-arachidoyl LPA）是溶血磷脂酸受体1（LPA1）的激动剂，并且是一种含有花生四烯酸的甘油磷脂，花生四烯酸位于sn-1位置。它能在主要表达LPA1而非LPA2-LPA6的人类肺成纤维细胞中诱导钙离子动员（EC50 = 3.6 µM）。在无细胞试验中，1-Arachidoyl LPA（2.5 µM）还能结合到过氧化物酶体增殖物激活受体γ（PPARγ）的配体结合域。人类尿液中也发现了该化合物。

化合物

Cat.No: T1684

Synonym: 尼替西农,NTBC,SC0735,Nitisone

Target: Others, Reactive Oxygen Species

Cat.No: T38293

Target: Others

S-Acetyl-L-glutathione

Cat.No: T36073

Target: Others

1(R)-(Trifluoromethyl)oleyl alcohol

Cat.No: T36003

Target: Others

Cat.No: T82314

Target: HDAC

1-Arachidoyl Lysophosphatidic Acid sodium

Cat.No: T83879

Synonym: 1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid

Cat. No.	Product Name	Target	Signaling Pathways
T3768	Epifriedelanol 表木栓醇,Epifriedelinol	Others	Others
	Epifriedelanol (Epifriedelinol) 是一种分离自 Ulmus davidiana 根皮中的三萜类化合物，具有抗肿瘤作用，可以减缓人原始细胞的衰老。

天然产物

Cat.No: T3768

Synonym: 表木栓醇,Epifriedelinol

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01557	MAGOH Protein, Human, Recombinant (His) MAGOHA,MAGOH1,mago-nashi homolog, proliferation-associated (...	Human	E. coli
	MAGOH (Mago Homolog, Exon Junction Complex Subunit) is a Protein Coding gene. MAGOH is the human homolog of Drosophila mago nashi, a protein that is required for normal germplasm development in the Drosophila embryo. In mammals, mRNA expression is not limited to the germplasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. The exon junction complex (EJCs) are deposited on messenger RNAs (mRNAs) during splicing and their core consi...
TMPK-01534	Chimeric HLA-A02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human*&Mouse, MHC (His & Avi) RING12,PSMB9,Proteasome chain 7,RMF,LMP-2,LMP2,MHC,Macropain...	Human & Mouse	HEK293 Cells
	The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma...
TMPK-01523	Chimeric HLA-A02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human*&Mouse, MHC (His & Avi) WAGR,WT33,AWT1,GUD,RMF,WT1,WIT-2,MHC,NPHS4GUD	Human & Mouse	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.
TMPK-01535	Chimeric HLA-A02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human*&Mouse, MHC (His & Avi) Macropain chain 7,LMP2,Proteasome chain 7,RING12,PSMB9,MHC,R...	Human & Mouse	HEK293 Cells
	The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma...
TMPK-01522	Chimeric HLA-A02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human*&Mouse, MHC (His & Avi) RMF,WT33,WIT-2,MHC,WAGR,AWT1,GUD,WT1,NPHS4GUD	Human & Mouse	HEK293 Cells
	The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A0201 WT-1 (RMFPNAPYL) complex Protein is a complex of HLA-A0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1.

重组蛋白

MAGOH Protein, Human, Recombinant (His)

Cat.No: TMPY-01557

Species: Human

Expression System: E. coli

Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01534

Species: Human & Mouse

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01523

Species: Human & Mouse

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01535

Species: Human & Mouse

Expression System: HEK293 Cells

Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human&Mouse, MHC (His & Avi)

Cat.No: TMPK-01522

Species: Human & Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71893	Clobetasol Propionate-d5
	Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the t...

同位素标记化合物

Clobetasol Propionate-d5

Cat.No: T71893

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼