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Search Results for " generalized "

Targets Recommended: Serotonin Transporter

18

抑制剂 & 化合物

3

天然产物

2

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T7061	Duloxetine	Serotonin Transporter	Neuroscience
	Duloxetine 是一种 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂，Ki=4.6 nM，可作用于广泛性焦虑症的研究。
T1471	Duloxetine hydrochloride Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI)，Ki=4.6 nM，可用于广泛性焦虑症的研究。
T2132	Buspirone hydrochloride Buspirone HCl,盐酸丁螺环酮,Narol,Buspar	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Buspirone hydrochloride (Buspar) 是一种 5HT(1A) 受体激动剂，可用于研究广泛性焦虑症。
T13569	Benin Butocine,Butocin	Others	Others
	Benin (Butocine) 是细胞生长抑制剂，可用于研究广义的乳腺癌。
T68058	Dulozafone F1933	Others	Others
	Dulozafone (F1933) 具有抗在脑杏仁核点燃模型中显示出抗惊厥活性，可保护完全点燃的大鼠免受全身性癫痫发作。
T7136	AZD-6280	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	AZD-6280 是一种新型的亚型选择性 GABAAα2/3 受体阳性调节剂，用于治疗广泛性焦虑症。
T12156	N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea	Others	Others
	N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea 是一种抗惊厥剂，对广泛强直和部分性发作挛性具有潜在的研究价值。
T17174	Troriluzole BHV4157,BHV-4157,BHV-4157a,FC 4157,BHV 4157	transporter	Metabolism
	Troriluzole 是一种具有口服活性谷氨酸调节剂，具有抗癌活性。Troriluzole 可提高位于神经胶质细胞的兴奋性氨基酸转运体的表达，可用于研究脊髓小脑性共济失调、阿尔茨海默病和广泛性焦虑症 (GAD) 。
T1249	Beclamide N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon,贝克拉胺(INN)	Others	Others
	Beclamide (Chlorakon) 是一种抗惊厥药，具有抗惊厥作用。
T0675	Topiramate RWJ 17021,McN 4853,托吡酯	Potassium Channel; Calcium Channel; GABA Receptor; Sodium Channel; GluR; Carbonic Anhydrase; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Topiramate (RWJ 17021) 是一种GluR5受体拮抗剂，可通过增强GABAergic 活性，抑制kainate/AMPA 受体，抑制钠和钙通道的电压敏感，增加钾电导并抑制碳酸酐酶来产生抗癫痫作用，用于治疗部分性和全身性癫痫发作。
T76778	Risankizumab Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor	Immunology/Inflammation
	Risankizumab (BI 655066) 是一种人源化靶向 IL-23 p19 亚基的 IgG 单克隆抗体(Kd <10 pM)。 Risankizumab 能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生，IC50 值为 2 pM。Risankizumab 可用于预防和治疗如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病类的免疫性和炎症性疾病。
T1885L	Siramesine Fumarate LU-28179,LU-28-179,LU 28 179	Others	Others
	Siramesine Fumarate, a sigma receptor agonist, is used potentially for the treatment of generalized anxiety disorder.
T14120	ACT-709478	Others	Others
	ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1].
T61376	Opipramol	Others	Others
	Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].
T27968	M-5011 T-3788,S-MTPPA,M 5011,M-5011C	Others	Others
	M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially inhibits the generalized bone loss a
T77032	Imsidolimab
	Imsidolimab (ANB 019) 是一种高亲和力、人源化的抗IL-36R 单克隆抗体。Imsidolimab 拮抗IL-36细胞因子信号传导。Imsidolimab 在泛发性脓疱型银屑病 (GPP) 和其他炎症性皮肤病中有潜在应用。
T68976	Piragliatin	Others	Others
	Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus. Piragliatin has an acute glucose-lowering action in patients with mild type 2 diabetes, mainly mediated through a generalized enhancement of β-cell function and through fasting restricted changes in ...
T70063	GYKI 52466 HCl	Others	Others
	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general...

化合物

Cat.No: T7061

Target: Serotonin Transporter

Duloxetine hydrochloride

Cat.No: T1471

Synonym: Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Buspirone hydrochloride

Cat.No: T2132

Synonym: Buspirone HCl,盐酸丁螺环酮,Narol,Buspar

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T13569

Synonym: Butocine,Butocin

Target: Others

Cat.No: T68058

Synonym: F1933

Target: Others

Cat.No: T7136

Target: GABA Receptor

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

Cat.No: T12156

Target: Others

Cat.No: T17174

Synonym: BHV4157,BHV-4157,BHV-4157a,FC 4157,BHV 4157

Target: transporter

Cat.No: T1249

Synonym: N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon,贝克拉胺(INN)

Target: Others

Cat.No: T0675

Synonym: RWJ 17021,McN 4853,托吡酯

Target: Potassium Channel, Calcium Channel, GABA Receptor, Sodium Channel, GluR, Carbonic Anhydrase, iGluR

Cat.No: T76778

Synonym: Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066

Target: IL Receptor

Siramesine Fumarate

Cat.No: T1885L

Synonym: LU-28179,LU-28-179,LU 28 179

Target: Others

Cat.No: T14120

Target: Others

Cat.No: T61376

Target: Others

Cat.No: T27968

Synonym: T-3788,S-MTPPA,M 5011,M-5011C

Target: Others

Cat.No: T77032

Cat.No: T68976

Target: Others

Cat.No: T70063

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4762	L-Pipecolic acid L-哌啶酸,L-Homoproline,H-HoPro-OH	Endogenous Metabolite	Metabolism
	L-Pipecolic acid (L-Homoproline) 是赖氨酸的分解产物，它能在患有常染色体遗传性疾病的婴儿体液中积累，比如新生儿肾上腺机能障碍， Zellweger 综合征等。
T8769	Harmaline hydrochloride Harmidine hydrochloride	Others	Others
	Harmaline hydrochloride (Harmidine hydrochloride) 是一种荧光吲哚生物碱，来自 harmala 生物碱和 β-咔啉。它是 harmine 的部分氢化形式。 Harmaline 通过诱导下橄榄神经元的节律性放电在正常大鼠中产生全身性震颤。
T40910	Cognac oil	Others	Others
	Cognac oil, predominantly derived from wine lees, exhibits distinctive fatty acid compositions, characterized by high proportions of Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), and Oleic acid (8.3%) among other fatty acids. Notably, the application of Cognac oil enhances the permeability of Rhodamine 6G (R6G) across various membranes, resulting in a generalized increase in permeation.

天然产物

L-Pipecolic acid

Cat.No: T4762

Synonym: L-哌啶酸,L-Homoproline,H-HoPro-OH

Target: Endogenous Metabolite

Harmaline hydrochloride

Cat.No: T8769

Synonym: Harmidine hydrochloride

Target: Others

Cat.No: T40910

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04303	FAM20C Protein, Human, Recombinant (His) GEF-CK,DMP4,RNS,DMP-4,family with sequence similarity 20, me...	Human	Baculovirus Insect Cells
	The Family with sequence similarity 20 member C (FAM20C) catalyzes the phosphorylation of secreted proteins, and participates in a variety of biological processes, including cell proliferation, migration, mineralization, and phosphate homeostasis. FAM20C is an evolutionarily reserved molecule highly expressed in mineralized tissues. Mutations in the Family with sequence similarity (FAM) 20 gene family are associated with mineralized tissue phenotypes in humans. Among these genes, FAM20A mutation...
TMPY-04534	GDF-8 Protein, Mouse, Recombinant (hFc) 骨肉瘤源生长因子,Cmpt,myostatin,Gdf8	Mouse	HEK293 Cells
	GDF-8 / Myostatin / MSTN is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. GDF-8 / Myostatin / MSTN is highly expressed in skeletal muscle, and myostatin loss-of-function le...

重组蛋白

FAM20C Protein, Human, Recombinant (His)

Cat.No: TMPY-04303

Species: Human

Expression System: Baculovirus Insect Cells

GDF-8 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-04534

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T11113	Duloxetine D3 hydrochloride (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride	Others	Others
	Duloxetine D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) i
TMID-0201	Buspirone-d8 HCl (n-butyl-d8)
	Buspirone-d8 HCl (n-butyl-d8) 是 Buspirone HCl 的氘代化合物。Buspirone HCl 的 CAS 号为 33386-08-2。Buspirone hydrochloride 是一种 5HT(1A) 受体激动剂，可用于研究广泛性焦虑症。
TMIJ-0300	Duloxetine-d7
	Duloxetine-d7 是 Duloxetine 的氘代化合物。Duloxetine 的 CAS 号为 116539-59-4。Duloxetine 是一种 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂，Ki=4.6 nM，可作用于广泛性焦虑症的研究。

同位素标记化合物

Duloxetine D3 hydrochloride

Cat.No: T11113

Synonym: (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride

Target: Others

Buspirone-d8 HCl (n-butyl-d8)

Cat.No: TMID-0201

Cat.No: TMIJ-0300

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