Ganodericacid ε, a naturally occurring terpenoid, is extracted from the Fungus Ganoderma lucidum. This compound possesses an ED 50 value of 12.2 μg mL, as demonstrated in its impact on Meth-A tumor cells.
The binding affinities of ganodericacid DM andGanodericacid ζ (ÎGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganodericacid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganodericacid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.
Ganodericacid S, a positional isomer of ganodericacids, can be isolated from the fermented mycelia of Ganoderma lucidum. It can induce apoptosis in HeLa cells through the mitochondria pathway [1].
A novel combination of triterpenoids includes at least ganodericacid S (GAS), ganodericacid T (GAT), ganodericacid Me (GAMe), ganodericacid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca
The role of our hybrid molecules, an analogue of Salvianolic acid F, in compelling the glioma cells towards apoptosis by specifically perturbing the concentration of glutathione along with caspase 6.
Ganodericacid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane pr