galanin (119), human

Galanin (1-19), human, represents the fragment encompassing amino acids 1 to 19 of the human galanin neuropeptide. Galanin (GAL) is known for its extensive distribution and multifaceted biological roles, such as regulating hormone secretion, providing antinociceptive effects, and altering feeding behavior.

Galanin (1-30), human acetate (Galanin ) 是一种 30 个氨基酸的神经肽。 它是 GalR1 和 GalR2 受体的激动剂，Kis 均为 1 nM。

Galanin (Human) (Acetate)是一种含有30个氨基酸的神经肽和丙氨酸(GAL)受体激动剂。在表达重组人gal1受体的HEK293E 细胞(EC50= 0.031 nM)中，它抑制佛司可林诱导的cAMP 产生，并刺激表达重组人gal2受体的CHO 细胞(EC50= 12.3 nM)中肌醇磷酸的积累。Galanin (Human) (Acetate)诱导离体大鼠纵向眼底收缩，ec50值为13.8 nM。在大鼠福尔马林试验的第二阶段，鞘内给药人甘丙肽(3、10和30 nmol/只)可减少大鼠舔爪和退缩。

Galanin (1-30), human, is a 30-amino acid neuropeptide that acts as an agonist of GalR1 and GalR2 receptors with Kis of 1 nM. This endogenous peptide exhibits multiple endocrine, metabolic, and behavioral effects and has demonstrated activity on the intestinal system.

Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1

Galanin-Like Peptide (human) 是由60个氨基酸组成的神经肽，在调节摄食、体重和能量代谢方面具有重要功能。