FR167653 (FR167653 sulfate) is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo. FR167653 , an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity.
FR167653free base is an orally active p38 MAPK inhibitor and is effective in treating inflammation, relieving trauma, and ischemia-reperfusion injury in vivo. It also is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MA