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Search Results for " fibrous "

Targets Recommended: TGF-beta/Smad

6

抑制剂 & 化合物

1

天然产物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T77019	Garetosmab REGN 2477	TGF-beta/Smad	Stem Cells
	Garetosmab (REGN 2477) 是一种全人 IgG4 单克隆抗体，可选择性抑制激活素 A (activin A)，可作用于 COVID-44。Garetosmab 具有潜在的抗癌活性，可用于研究骨化性纤维发育不良 (FOP) 和癌症。
T1935	LDN193189 LDN-193189,DM-3189,LDN 193189	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN193189 (DM-3189) 是一种 BMP I 型受体的选择性抑制剂，可以抑制 ALK2 和 ALK3 (IC50=5/30 nM)，对 ALK4、ALK5 和 ALK7 的活性较弱。LDN193189 可以用于进行性骨化性纤维发育不良的研究。
T36697	8-Nitroguanine	Others	Others
	8-Nitroguanine 是由活性氮物引起的 DNA 硝化损伤的产物，可能是恶性纤维组织细胞瘤进展的潜在生物标志物。
T84392	14-Pentadecenoic Acid FA 15:1,ω-Pentadecenoic Acid	Others	Others
	14-Pentadecenoic acid, a 15-carbon long-chain fatty acid with an alkene functional group on the terminal carbon of its aliphatic tail, has been observed to undergo oxidation due to the growth of M. cerificans at the expense of the parent alkene. This compound is utilized in the creation of fibrous scaffold biomaterials for tissue engineering purposes and in constructing metallomesogenic side-chain polymers for coating capillary columns in gas chromatography applications.
T63325	ATX inhibitor 9	Others	Others
	ATX inhibitor 9 是增稠的杂芳基衍生物化合物，也是 ATX 的有效抑制剂。其中 Autotaxin (ATX)，也称为 ENPP2，是一种主要在肺癌细胞、支气管上皮细胞和肺泡巨噬细胞中高度表达的分泌酶。ATX inhibitor 9 对癌症或纤维退行性疾病具有研究潜力。
TP2182	Lamin fragment	Others	Others
	Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amin

化合物

Cat.No: T77019

Synonym: REGN 2477

Target: TGF-beta/Smad

Cat.No: T1935

Synonym: LDN-193189,DM-3189,LDN 193189

Target: ALK, TGF-beta/Smad

Cat.No: T36697

Target: Others

14-Pentadecenoic Acid

Cat.No: T84392

Synonym: FA 15:1,ω-Pentadecenoic Acid

Target: Others

ATX inhibitor 9

Cat.No: T63325

Target: Others

Cat.No: TP2182

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4601	9-Methoxycanthin-6-one	Others	Others
	9-Methoxycanthin-6-one 是存在于完整植株和不同外植体的愈伤组织中的 Canthin-6-one 生物碱，具有抗肿瘤作用。

天然产物

9-Methoxycanthin-6-one

Cat.No: T4601

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02863	LOX Protein, Mouse, Recombinant (His & Myc) Ras excision protein,Protein-lysine 6-oxidase,Lysyl oxidase,...	Mouse	Baculovirus Insect Cells
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture.
TMPH-03359	LOX Protein, Rat, Recombinant (His) Lysyl oxidase,Protein-lysine 6-oxidase,Lox	Rat	E. coli
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. LOX Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.0 kDa and the accession number is P16636.
TMPH-01969	LOX Protein, Human, Recombinant (His & Myc & SUMO) Protein-lysine 6-oxidase,LOX,Lysyl oxidase	Human	E. coli
	Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture. LOX Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 49.0 kDa and the accession number is P28300.
TMPY-04780	VMO1 Protein, Human, Recombinant vitelline membrane outer layer 1 homolog (chicken),PRO21055,...	Human	HEK293 Cells
	Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. VMO1 is regulated by estrogen and target microRNAs and it is a potential diagnostic marker of ovarian cancer in laying hens. VMO1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted mole...
TMPY-00375	VMO1 Protein, Human, Recombinant (mFc) ERGA6350,PRO21055,vitelline membrane outer layer 1 homolog (...	Human	HEK293 Cells
	Vitelline membrane outer layer protein 1 (VMO1), a basic protein present in the outer layer of the vitelline membrane of eggs, plays essential roles in separating the yolk from the egg white and preventing infection from bacteria by forming a barrier of fibrous layers in avian eggs. VMO1 is regulated by estrogen and target microRNAs and it is a potential diagnostic marker of ovarian cancer in laying hens. VMO1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag....
TMPU-00002	SOS1-Cat Protein, Human, Recombinant (His) SOS-1,Son of sevenless homolog 1	Human	E. coli
	Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM:610733]. NS4 is an autosomal dominant disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incid...

重组蛋白

LOX Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02863

Species: Mouse

Expression System: Baculovirus Insect Cells

LOX Protein, Rat, Recombinant (His)

Cat.No: TMPH-03359

Species: Rat

Expression System: E. coli

LOX Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-01969

Species: Human

Expression System: E. coli

VMO1 Protein, Human, Recombinant

Cat.No: TMPY-04780

Species: Human

Expression System: HEK293 Cells

VMO1 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00375

Species: Human

Expression System: HEK293 Cells

SOS1-Cat Protein, Human, Recombinant (His)

Cat.No: TMPU-00002

Species: Human

Expression System: E. coli

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