fak ligand-linker conjugate 1

FAK ligand-Linker Conjugate 1 is a chemical compound designed to facilitate PROTAC-mediated protein degradation. This compound consists of a ligand specifically targeting FAK and a PROTAC linker module, which acts as a recruitment agent for E3 ligases including VHL, CRBN, MDM2, and IAP[1].

PROTAC BRD4 ligand-1 是 PROTAC GNE-987 靶向 BRD4 蛋白的配体，也是一种 BET 的抑制剂。

SMARCA-BD ligand 1 for Protac 能够与 BAF ATPase 亚基 SMARCA2 结合，可用于 PROTAC 技术，用于降解 SMARCA2。

PROTAC ERRα ligand 1 是一种雌激素相关受体 α (ERRα) 拮抗剂，能够作用于 ERRα (IC50:0.04 μM)和 ERRγ (IC50:2.8 μM)。

SMARCA-BD ligand 1 for Protac dihydrochloride 是一种能够与 BAF ATPase 亚基 SMARCA2 结合的化合物，基于 PROTAC 技术，使 SMARCA2 降解。

E3 Ligase Ligand-linker Conjugate 54 是由Thalidomide和对应Linker组成的E3连接酶配体与连接子的复合物。它能够作为Cereblon配体招募CRBN蛋白，并在PROTACs分子合成中充当关键中间体。

PROTACPARP EGFR ligand 1 是一种活性化合物，可通过蛋白水解靶向嵌合体（PROTAC）技术用于合成双 PARPEGFR 降解剂的合成。

PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体，可募集 IAP 泛素连接酶以降解靶蛋白，可用于和雄激素受体配体欧联开发蛋白降解剂，可用于研究前列腺癌。

PROTAC BCR-ABL1 ligand 1 is the ligand of PROTAC .

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].

cIAP1 Ligand-Linker Conjugates 15 consists of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 15, is suitable for the development of SNIPERs[1].

PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.

ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds utility in the synthesis of a range of PROTACs, including one known as PROTAC ERRalpha Degrader-1. With its capability to induce degradation of ERRα, PROTAC ERRalpha Degrader-1 functions as an ERRα degrader[1].

K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively.

cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10.

cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1].

cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 2 Hydrochloride is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is utilized in the creation of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 12 is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 12, is valuable for creating SNIPERs[1].

TEAD ligand 1 是一种结合靶蛋白TEAD的配体，可用于合成PROTAC[TEAD degrader-1]。

E3 Ligase Ligand-linker Conjugate 5 由 Thalidomide 和相对应的 Linker 组成，是一种 E3 连接酶配体与连接子的结合体。它可作为 Cereblon 配体来招募 CRBN 蛋白，同时在完整 PROTACs 分子合成中充当关键的中间体。

E3 Ligase Ligand-linker Conjugate 48为E3泛素连接酶配体-Linker结合物，主要应用于PROTACs分子的合成。

TSPO ligand-1 对外周和中枢苯二氮卓受体有亲和力。TSPO ligand-1 是一种线粒体外膜跨膜结构域上与 AUTAC4 结合的蛋白，可诱导线粒体自噬 (autophagy) 促进胞内线粒体更新。TSPO ligand-1 参与胆固醇在胞内的转运，可作为脑损伤和神经变性的生物标志物。

PROTACBcl-xL ligand-1 是Bcl-xL 的配体，可用于PROTAC 的合成。

K-Ras ligand-Linker Conjugate 6 is a chemical compound that combines a ligand for K-Ras recruiting moiety and a PROTAC linker. This compound can recruit E3 ligases, including VHL, CRBN, MDM2, and IAP. K-Ras ligand-Linker Conjugate 6 is particularly useful in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 5 is a chemical compound that combines a ligand for the K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The K-Ras ligand-Linker Conjugate 5 plays a crucial role in the synthesis of PROTAC K-Ras Degrader-1, a highly potent K-Ras degrader. In SW1573 cells, this degrader exhibits an impressive degradation efficacy of ≥70% [1].

cIAP1 Ligand-Linker Conjugates 9 feature an IAP ligand specifically targeting the E3 ubiquitin ligase, along with a PROTAC linker. It is valuable tools for developing SNIPERs[1].

MAC glucuronide linker-1 is a noncleavable ADC linker used in antibody-drug conjugations (ADCs).

DENV ligand 1，作为DENV E蛋白的配体，可应用于合成PROTAC降解剂ZXH-8-004。

E3 ligase Ligand-Linker Conjugate 34是一种由Thalidomide和相应Linker组成的E3连接酶配体-连接子缀合物 (E3 Ligase Ligand-Linker Conjugates)。它能够作为Cereblon配体，招募CRBN蛋白，并且在PROTACs分子合成中扮演关键中间体的角色。

E3 Ligase Ligand-linker Conjugate 7 是由 Thalidomide 和相应的 Linker 缀合而成的 E3 连接酶配体-连接子复合体（E3 Ligase Ligand-Linker Conjugates）。它能作为 Cereblon 配体来募集 CRBN 蛋白，并作为合成完整 PROTACs 分子的关键中间体。

Bcl-2 Bcl-xI ligands 1 作为一种Bcl-2 Bcl-xI配体，主要用于合成PROTAC Bcl-2 Bcl-xI Degrader-1。

SMARCA-BD ligand 1 hydrochloride forProtac是一种基于PROTAC技术的化合物，能够与BAF ATPase亚基SMARCA2结合，用于降解SMARCA2。

PROTACPTK6 ligand-1是用于合成BTK激酶抑制剂的中间体，也可作为ARD-61合成的原料。

cIAP1 Ligand-Linker Conjugates 16 refers to a specific type of ligase ligand-linker conjugate, possessing the ability to engage with E3 ligases, which finds application in the synthesis of PROTACs.

GID4 Ligand 1 是细胞渗透性的、高度选择性的 GID4 结合剂，其 IC50 值为 5.4 μM，Kd 值为 5.6 μM。GID4 Ligand 1 在细胞中能够结合 GID4，其 EC50 值为 558 nM。GID4 Ligand 1 能够用于 PROTACs 的合成。

Aberrant tau ligand 1 是异常 tau 蛋白的配体，可用于合成异常形态的 PROTAC Tau 降解剂 [QC-01-175]。

cIAP1 Ligand-Linker Conjugates 3 are chemical compounds comprising an IAP ligand designed specifically for the E3 ubiquitin ligase and a PROTAC linker. These conjugates, denoted as cIAP1 Ligand-Linker Conjugates 3, find utility in the design of SNIPERs, short for Specific and Non-genetic IAP-dependent Protein Erasers [1].

cIAP1 Ligand-Linker Conjugates 1 is composed of an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 1, is particularly useful in the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 15 hydrochloride is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is useful in the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. It is primarily utilized in the development of SNIPERs, a molecular tool for targeted protein degradation[1].

K-Ras ligand-Linker Conjugate 4 is a chemical compound that combines a ligand for K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The compound has the potential to be used in the synthesis of PROTAC K-Ras Degrader-1, a powerful degrader of K-Ras that has been shown to exhibit a degradation efficacy of ≥70% in SW1573 cells[1].

AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be used in the development of SNIPER[1].

VHL Ligand-Linker Conjugates 17 are chemical compounds that consist of a VHL ligand specialized for the E3 ubiquitin ligase, as well as a PROTAC linker. These conjugates are utilized in the synthesis of various PROTACs, including the notable ARD-266. ARD-266 is an exceptionally effective androgen receptor (AR) PROTAC degrader[1].

E3 Ligase Ligand-linker Conjugate 28是E3连接酶配体与连接子的缀合物 (E3 Ligase Ligand-Linker Conjugates)，由Thalidomide和对应Linker构成。E3 Ligase Ligand-linker Conjugate 28可作为Cereblon配体募集CRBN蛋白，并作为关键中间体进行完整PROTACs分子合成。