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Search Results for " exonuclease "

Targets Recommended: DNA/RNA Synthesis

8

抑制剂 & 化合物

10

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6456	CRT0044876 NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	CRT0044876 (7-NO2-ICA) 是一种高选择性的嘌呤/嘧啶核苷核酸内切酶 1 抑制剂，IC50约为 3 μM。它也是 APE1 所属的核酸外切酶 III 家族的特异性抑制剂，可抑制 APE1 的 AP 内切酶、3′-磷酸二酯酶和 3′-磷酸酶活性，可增强几种 DNA 碱基靶向化合物的细胞毒性。
T38709	PFM39	Others	Others
	PFM39 是一种选择性 MRE11 核酸外切酶抑制剂，是 Mirin 类似物，可延长有丝分裂。PFM39 抑制 HR，可缓解由 EXO1/BLM 耗竭引起的修复缺陷。
T3134	(Z)-Mirin Mirin	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	(Z)-Mirin 是 Mre11–Rad50–Nbs1 (MRN) 复合物抑制剂，可抑制 Mre11 相关的核酸外切酶活性。
T9168	NSC 617145 NSC617145,NSC-617145	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	NSC 617145 (NSC617145) 是一种 WRN 解旋酶抑制剂，IC50值为 230 nM。它以浓度依赖性方式抑制 WRN 解旋酶的 ATP 酶，并诱导双链断裂和染色体异常。
T74702	5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)	Others	Others
	5'-ODMT cEt N-Bz A Phosphoramidite Amidite 为一种锁核酸(LNA)类似物，与LNA具有相似的杂交及错配鉴别特性，并展现出对核酸外切酶消化的抗性。
T76102	Carboxypeptidase B	Others	Others
	Carboxypeptidase B 是一种肽链外切酶，可专一性地降解肽链。Carboxypeptidase B 从 C 端逐个降解，释放出游离氨基酸。Carboxypeptidase B 只水解以碱性氨基酸（如精氨酸和赖氨酸）为 C 末端残基的肽键。
T78938	H3B-968	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	H3B-968为一种高效Werner综合征蛋白(WRN)抑制剂，IC50约为10 nM，可抑制具有解旋酶、ATP酶和外切酶活性的WRN。WRN在癌症研究中具有显著的合成致死潜力。H3B-968通过与ATP竞争抑制WRN解旋酶活性。
T60273	Mirin	Others	Others
	Mirin 是一种有效的 Mre11-Rad50-Nbs1 (MRN)复合物抑制剂。Mirin 可在不影响 ATM 蛋白激酶活性的情况下，抑制ATM 的 MRN 依赖性激活(IC50=12 μM)，并抑制 Mre11 相关的核酸外切酶活性。与其靶向 MRN 复合物的能力一致，Mirin 可消除哺乳动物细胞中的 G2/M 检查点和同源性依赖性修复。

化合物

Cat.No: T6456

Synonym: NSC 69877,7-NO2-ICA,7-硝基吲哚-2-甲酸,NSC 69877,7-Nitroindole-2-Carboxylic Acid

Target: DNA/RNA Synthesis

Cat.No: T38709

Target: Others

Cat.No: T3134

Synonym: Mirin

Target: ATM/ATR

Cat.No: T9168

Synonym: NSC617145,NSC-617145

Target: DNA/RNA Synthesis

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)

Cat.No: T74702

Target: Others

Carboxypeptidase B

Cat.No: T76102

Target: Others

Cat.No: T78938

Target: DNA/RNA Synthesis

Cat.No: T60273

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02930	TREX1 Protein, Mouse, Recombinant (His & Myc) 3'-5' exonuclease TREX1,Three-prime repair exon...	Mouse	E. coli
	TREX1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.1 kDa and the accession number is Q91XB0.
TMPH-02201	TREX1 Protein, Human, Recombinant (His & MBP) TREX1,Three-prime repair exonuclease 1,3'-5' ex...	Human	Baculovirus Insect Cells
	TREX1 Protein, Human, Recombinant (His & MBP) is expressed in Baculovirus insect cells with N-10xHis-MBP and C-6xHis tag. The predicted molecular weight is 83.6 kDa and the accession number is Q9NSU2.
TMPK-01138	PLD4 Protein, Human, Recombinant (His) 5'-3' exonuclease PLD4,PLD 4,Phospholipase D4,Choli...	Human	HEK293 Cells
	Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. furthermore, its expression was associated with clinical staging of colon cancer. Then, THP-1 as a cell model induced into TAMs. PLD4 could be involved in the activation process of M1 phenotype macrophages. PLD4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cel...
TMPK-01079	PLD4 Protein, Mouse, Recombinant (His) Choline phosphatase 4,5'-3' exonuclease PLD4,Phosph...	Mouse	HEK293 Cells
	Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. furthermore, its expression was associated with clinical staging of colon cancer. Then, THP-1 as a cell model induced into TAMs. PLD4 could be involved in the activation process of M1 phenotype macrophages. PLD4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cel...
TMPH-02829	Phospholipase D3/PLD3 Protein, Mouse, Recombinant (His) Phosphatidylcholine-hydrolyzing phospholipase D3,Pld3,Cholin...	Mouse	E. coli
	5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.
TMPH-00427	DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant DNA polymerase IV,dinB,Pol IV	Colwellia psychrerythraea	E. coli
	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant is expressed in E. coli expression syste...
TMPH-03615	Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO) rnj,Ribonuclease J	Synechocystis	E. coli
	An RNase that has 5'-3' exonuclease and possibly endoonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 86.4 kDa and the accession number is P54123.
TMPH-00426	DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) dinB,DNA polymerase IV,Pol IV	Colwellia psychrerythraea	E. coli
	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His) is expressed in E. coli expression...
TMPY-02433	APE1/APEX1 Protein, Human, Recombinant (His) APEX,HAP1,APX,APE,APEX nuclease (multifunctional DNA repair ...	Human	E. coli
	The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diesterase, 3'-5' exonuclease and DNA 3'-phosphatase activities.Although Apex mRNA was expressed ubiquitously, the levels varied significantly, suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis, relatively high levels in the...
TMPH-02649	FAN1 Protein, Mouse, Recombinant (His & Myc) Fanconi-associated nuclease 1,Myotubularin-related protein 1...	Mouse	E. coli
	Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to e...

重组蛋白

TREX1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02930

Species: Mouse

Expression System: E. coli

TREX1 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPH-02201

Species: Human

Expression System: Baculovirus Insect Cells

PLD4 Protein, Human, Recombinant (His)

Cat.No: TMPK-01138

Species: Human

Expression System: HEK293 Cells

PLD4 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01079

Species: Mouse

Expression System: HEK293 Cells

Phospholipase D3/PLD3 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02829

Species: Mouse

Expression System: E. coli

DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant

Cat.No: TMPH-00427

Species: Colwellia psychrerythraea

Expression System: E. coli

Ribonuclease J Protein, Synechocystis sp., Recombinant (His & SUMO)

Cat.No: TMPH-03615

Species: Synechocystis

Expression System: E. coli

DNA polymerase IV Protein, Colwellia psychrerythraea, Recombinant (His)

Cat.No: TMPH-00426

Species: Colwellia psychrerythraea

Expression System: E. coli

APE1/APEX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02433

Species: Human

Expression System: E. coli

FAN1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02649

Species: Mouse

Expression System: E. coli

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