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Search Results for " electron transport chain "

Targets Recommended: Others

12

抑制剂 & 化合物

6

天然产物

8

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T20958	Hexazinone	Others	Others
	Hexazinone 是三嗪家族的广谱除草剂。 Hexazinone 通过与光系统 II 中电子传递链的 D-1 醌蛋白结合来抑制光合作用。
T5117	Hexaflumuron	Others	Others
	Hexazinone 是一种三嗪家族的非选择性除草剂。它能够同光系统 II 电子传递链的 D-1 醌蛋白结合，抑制光合作用的发生。
T40515	Metamitron	Others	Others
	Metamitron 是一种光合电子传递链抑制剂，可用作化学稀释剂。
T0412	Idebenone 艾地苯醌,CV-2619	Apoptosis; Antioxidant; Mitochondrial Metabolism	Apoptosis; Metabolism; oxidation-reduction
	Idebenone (CV-2619) 是一种线粒体保护剂，具有神经保护功效，可用于研究阿尔茨海默病、亨廷顿舞蹈病，可透过血脑屏障，诱导细胞凋亡。
T5337	IACS-010759 IACS-10759,IACS 10759,IACS10759	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	IACS-010759 是一种口服有效的线粒体氧化磷酸化复合物 I 抑制剂。它在依赖 OXPHOS 的脑癌和急性髓性白血病模型中抑制增殖并诱导细胞凋亡，有研究复发/难治性 AML 和实体瘤潜力。
T12049	MitoTam bromide, hydrobromide MitoTam bromide hydrobromide	Others	Others
	MitoTam bromide hydrobromide is an electron transport chain (ETC) inhibitor.
T34084	Plastoquinone Q 254,Q-254,Q254	Others	Others
	Plastoquinone is a polyunsaturated side-chain quinone derivative which is an important link in the electron transport chain of green plants during the photosynthetic conversion of light energy by photophosphorylation into the potential energy of chemical
T27444	GSK 932121 GSK-932121,GSK932121	Others	Others
	GSK 932121 is a potent antimalarial agent. GSK 932121 inhibits selectively the electron-transport chain in P. falciparum at the cytochrome bc1 level (complex III).
T36203	Menaquinone 9 MK-9,Vitamin K2(45),Menaquinone 9	Others	Others
	Menaquinone 9 (MK-9) is a vitamin K2 analog that has been found in various bacteria, including E. coli. MK-9 is UV-sensitive and binds to soluble nitrate reductase, a component of the bacterial electron transport chain. In vivo, MK-9 increases plasma prothrombin concentration in vitamin K-deficient rats.
T36114	Coenzyme Q2	Others	Others
	Coenzyme Q10 is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. In its reduced form, it acts as an antioxidant. Coenzyme Q2 is a precursor of coenzyme Q10 that has 2, rather than 10, isoprenoid units on the ubiquinone base. It can act as an electron acceptor for bacterial Complex I. In mammalian cells, exogenous coenzyme Q2 prevents the production of reactive oxygen species associated with Complex I activity. For...
T37519	Diquat (bromide)	Others	Others
	Diquat is a bipyridylium herbicide that, as a stable radical, acts as an electron acceptor in the electron transport chain and is reoxidized by molecular oxygen, producing reactive oxygen species (ROS).1Diquat administration has been used to induce oxidative stressin vitroand in animal models.2,3,4It increases the production of ROS and decreases the mitochondrial membrane potential in mitochondria isolated from porcine intestine leading to mitophagy when administered at a dose of 100 mg/kg.2Form...
T37498	Antimycin A4	Others	Others
	Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The antimycin A complex is a mixture of antimycins A1, A2, A3, and A4 that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties. It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial elect...

化合物

Cat.No: T20958

Target: Others

Cat.No: T5117

Target: Others

Cat.No: T40515

Target: Others

Cat.No: T0412

Synonym: 艾地苯醌,CV-2619

Target: Apoptosis, Antioxidant, Mitochondrial Metabolism

Cat.No: T5337

Synonym: IACS-10759,IACS 10759,IACS10759

Target: Apoptosis, Others, Mitochondrial Metabolism

MitoTam bromide, hydrobromide

Cat.No: T12049

Synonym: MitoTam bromide hydrobromide

Target: Others

Cat.No: T34084

Synonym: Q 254,Q-254,Q254

Target: Others

Cat.No: T27444

Synonym: GSK-932121,GSK932121

Target: Others

Cat.No: T36203

Synonym: MK-9,Vitamin K2(45),Menaquinone 9

Target: Others

Cat.No: T36114

Target: Others

Diquat (bromide)

Cat.No: T37519

Target: Others

Cat.No: T37498

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T8433	HQNO	Mitochondrial Metabolism	Metabolism
	HQNO 是一种电子传递链抑制剂，对 complex III 的Kd 值为 64 nM，由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。
T5573	Coenzyme Q9 辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式，是电子传递链中的一种双亲分子组分，具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降，改善左心室功能，减少心肌梗死面积和心肌细胞凋亡。
T5300	Ammonium formate 甲酸铵,Formic acid ammonium salt	Others	Others
	Ammonium formate (Formic acid ammonium salt) 是最简单的羧酸。它通过抑制细胞色素氧化酶活性（电子传递链的末端电子受体）来负责代谢性酸中毒和破坏线粒体电子传递和能量产生。
T21494	Oligomycin 寡霉素	HIF	Angiogenesis; Chromatin/Epigenetic
	Oligomycin 是一种抗真菌抗生素，是 H+-ATP 合成酶的抑制剂。Oligomycin 能够阻断氧化磷酸化和电子传递链。Oligomycin 对缺氧性肿瘤细胞 HIF-1alpha 表达具有抑制作用。
T5291	Malonic acid Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid	Others	Others
	Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子：它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关，这是一种先天性代谢错误。
TN4418	Lasiodiplodin	ATPase; TNF	Apoptosis; Membrane transporter/Ion channel
	Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron transport chain.

天然产物

Cat.No: T8433

Target: Mitochondrial Metabolism

Cat.No: T5573

Synonym: 辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9

Target: Apoptosis, Endogenous Metabolite

Ammonium formate

Cat.No: T5300

Synonym: 甲酸铵,Formic acid ammonium salt

Target: Others

Cat.No: T21494

Synonym: 寡霉素

Target: HIF

Cat.No: T5291

Synonym: Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid

Target: Others

Cat.No: TN4418

Target: ATPase, TNF

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02148	SDHA Protein, Human, Recombinant (His) SDHA,Succinate dehydrogenase [ubiquinone] flavoprotein subun...	Human	E. coli
	Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.
TMPH-01744	NOX1 Protein, Human, Recombinant (His) NADH/NADPH mitogenic oxidase subunit P65-MOX,NADPH oxidase 1...	Human	E. coli
	NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis t...
TMPH-00079	Beta-amylase 3, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His) BAM3,CTBMY,1,4-alpha-D-glucan maltohydrolase,Beta-amylase 3,...	Arabidopsis thaliana	E. coli
	Beta-amylase activity. No alpha-amylase activity. Involved in cold resistance. Mediates the accumulation of maltose upon freezing stress, thus contributing to the protection of the photosynthetic electron transport chain. Plays a role in the circadian-regulated starch degradation and maltose metabolism in chloroplasts, especially at night. More active on phosphorylated glucan. Interacts directly with starch or other alpha-1,4-glucan.
TMPJ-00105	SOD2 Protein, Human, Recombinant (His) Superoxide Dismutase [Mn] Mitochondrial,SOD2	Human	HEK293 Cells
	Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. It is reported that oxidative stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly convert potential ...
TMPH-02617	COX5A Protein, Mouse, Recombinant (His & SUMO) Cytochrome c oxidase subunit 5A, mitochondrial,COX5A,Cytochr...	Mouse	E. coli
	Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over t...
TMPJ-00104	SOD2 Protein, Human, Recombinant (E. coli, His) SOD2,Superoxide Dismutase [Mn] Mitochondrial	Human	E. coli
	Superoxide Dismutase (SOD2) is a number of the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. The SOD2 protein transforms toxic superoxide and a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. Genetic variation in SOD2 is associated with microvascular complications of diabetes type 6 (MVCD6), idiopathic cardiomyopathy (IDC), sporadic motor neuron dis...
TMPJ-01066	CYCS Protein, Human, Recombinant (His) CYC,Cytochrome C,CYCS	Human	E. coli
	Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as a central component of the electron transport chain in mitochondria. CYCS transfers electrons between Complexes III (Coenzyme Q - Cyt C reductase) and IV (Cyt C oxidase). CYCS plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic...
TMPH-02530	ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO) ATP synthase F1 subunit beta,Atp5b,Atp5f1b,ATP synthase subu...	Mouse	E. coli
	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain ...

重组蛋白

SDHA Protein, Human, Recombinant (His)

Cat.No: TMPH-02148

Species: Human

Expression System: E. coli

NOX1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01744

Species: Human

Expression System: E. coli

Beta-amylase 3, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00079

Species: Arabidopsis thaliana

Expression System: E. coli

SOD2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00105

Species: Human

Expression System: HEK293 Cells

COX5A Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02617

Species: Mouse

Expression System: E. coli

SOD2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-00104

Species: Human

Expression System: E. coli

CYCS Protein, Human, Recombinant (His)

Cat.No: TMPJ-01066

Species: Human

Expression System: E. coli

ATP5B Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02530

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0041	Menaquinone-9-d7 Vitamin K2-MK9-d7
	Menaquinone-9-d7 是 Menaquinone-9 的氘代化合物。Menaquinone-9 的 CAS 号为 523-39-7。Menaquinone 9 (MK-9) 是一种维生素 K2 类似物，已在包括大肠杆菌在内的各种细菌中发现。Menaquinone 9 对紫外线敏感，可与细菌电子传输链的一种成分可溶性硝酸还原酶结合。

同位素标记化合物

Menaquinone-9-d7

Cat.No: TMID-0041

Synonym: Vitamin K2-MK9-d7

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