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Search Results for " diphosphate-dependent "

Targets Recommended: Potassium Channel

3

抑制剂 & 化合物

1

化合物库

3

重组蛋白

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Cat. No.	Product Name
L1710	抗COVID-19化合物库		1133 compounds
	1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合，可用于高通量和高内涵筛选；

化合物库

抗COVID-19化合物库

Cat.No: L1710

Compounds: 1133

Cat. No.	Product Name	Target	Signaling Pathways
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T83785	2-Chloroadenosine-5'-O-diphosphate sodium 2-chloro ADP	Others	Others
	2-Chloroadenosine-5'-O-diphosphate是一种腺苷5'二磷酸（ADP）的衍生物。它在浓度依赖性的方式下，促进了人类富含血小板的血浆中的聚集，并抑制了由前列腺素E2（PGE2）诱导的环磷酸腺苷（cAMP）的产生。2-Chloroadenosine-5'-O-diphosphate引起预收缩的孤立的豚鼠taenia coli条带放松（pD2 = 6.74），降低大鼠的动脉血压。此外，它还抑制了热休克蛋白70（Hsp70）家族成员mortalin的ATP酶活性（人类酶的表观Ki = 45.05 µM）。
T36844	Inostamycin A	Others	Others
	Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 μg/ml.2Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a con...

化合物

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

2-Chloroadenosine-5'-O-diphosphate sodium

Cat.No: T83785

Synonym: 2-chloro ADP

Target: Others

Cat.No: T36844

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02475	OGDC-E Protein, Mouse, Recombinant (His & SUMO) Ogdh,Alpha-ketoglutarate dehydrogenase,Thiamine diphosph...	Mouse	E. coli
	OGDC-E Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.8 kDa and the accession number is Q60597.
TMPH-00850	OGDC-E1 Protein, Human, Recombinant (His & SUMO) OGDH,Alpha-ketoglutarate dehydrogenase,2-oxoglutarate dehydr...	Human	E. coli
	OGDC-E1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 59.1 kDa and the accession number is Q02218.
TMPJ-00937	RRM2 Protein, Human, Recombinant (His) RRM2,RR2,Ribonucleotide Reductase Small Subunit,Ribonucleoti...	Human	HEK293 Cells
	Ribonucleoside-Diphosphate Reductase Subunit M2 (RRM2) belongs to the ribonucleoside diphosphate reductase small chain family. The reductase of RRM2 catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. RRM2 supplies the precursors essential for DNA synthesis. RRM2 catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Phosphorylation on Ser-20 relieves the in...

重组蛋白

OGDC-E Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02475

Species: Mouse

Expression System: E. coli

OGDC-E1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00850

Species: Human

Expression System: E. coli

RRM2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00937

Species: Human

Expression System: HEK293 Cells

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