dc-0-nh2

2-chloro-5-(16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)benzoic acid 可用于合成多种有机化合物。

AMPK activator 2 hydrochloride 是一种含氟氯胍衍生物，可上调 AMPK 信号通路并下调 mTOR/4EBP1/p70S6K。AMPK activator 2 hydrochloride 抑制人类癌细胞系 (UMUC3、T24、A549) 的增殖和迁移。

Autocamtide-2-related inhibitory peptide, myristoylated acetate 是CaM 激酶II 抑制剂;是 Autocamtide-2相关抑制肽的增强细胞渗透性衍生物。

The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then ade

5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite 是一种广泛具有抗肿瘤活性的嘌呤核苷类似物，主要用于靶向惰性淋巴系统恶性肿瘤。其抗癌机制主要通过抑制 DNA 合成和诱导细胞凋亡 (apoptosis) 来实现。

3'-dC(Bz)-2'-phosphoramidite is a Nucleoside Phosphoramidite.

2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotides.

(±)-2'-hydroxy Ceramide (d18:0 18:0)' 为一种鞘磷脂，能够自 ADP 刺激下的哺乳动物血小板中提取。

Thalidomide-NH-CBP p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).

Dmt-2'-f-dc(ac) amidite (2'-F-Ac-dC Phosphoramidite) is a phosphoramidite compound utilized in the synthesis of cyclic purine dinucleotides.'

C2 Adamantanyl globotriaosylceramide (AdaGb3) is a bioactive sphingolipid and water-soluble form of globotriaosylceramide that contains an adamantanyl group in place of the fatty acyl chain. It inhibits Vero toxin binding to globotriaosylceramide in an ELISA assay when used at a concentration of 10 μM. AdaGb3 decreases cell surface expression of P-glycoprotein (P-gp) and reduces efflux of rhodamine 123 in MDCK cells. It also increases apical-to-basal transport of vinblastine in human intestinal C2BBe1 cells.

DMT-2'-F-Bz-dC is a Nucleoside Derivative - Fluoro-modified nucleoside, Protected nucleoside with NH2 OH open.

5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.

Thalidomide-NH-(CH2)2-NH2 TFA 是一种烷基修饰的 Thalidomide，用作 Cereblon 配体以招募 CRBN 蛋白。它是在以 CRBN 为基础设计的 PROTAC 分子合成中的关键中间体，并用于合成针对 SHP2 蛋白的 PROTAC 小分子。

C2 Ceramide (d14:1 2:0) is a bioactive sphingolipid. Dietary administration of C2 ceramide (d14:1 2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fractional shortening and the number of normal cardiac contractile events in Drosophila.

C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively.

C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK signaling. It induces death of keratinocytes (20% viability) with an ED50 value of 30 μM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at a concentration of 20 μM, and induces internucleosomal DNA fragmentation. In addition, it inhibits the activation of phospholipase D (PLD) mediated by muscarinic acetylcholine receptors in vitro.

2-MSP-5-HA-GGFG-NH-CH2-O-CH2-CO-Exatecan 作为 ADC 中的药物-linker 偶联物，包含一个可裂解的 linker 和 Exatecan。此偶联物能够与抗 Her3 抗体进行连接。

C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.

5’-O-DMT-N4-Ac-2’-F-dC is a modified nucleoside and can be used to synthesize DNA or RNA.

Nucleoside Derivatives - Fluoro-modified nucleosides; 2’-Modified nucleosides; Nucleoside Phosphoramidites

C2 Dihydro Ceramide (d18:0 2:0) (C2 Dihydroceramide) 是短链的神经酰胺，是神经酰胺合成前体，可刺激 ABCA1 介导的胆固醇外流。

2-Desoxypleniradin-4-0-a-L-rhamnopyranoside为一种黄酮类化合物，可自Helenium radiatum中提取。

2'-Deoxy-2'-fluoro-5-methyl-araobinocytidine 5'-triphosphate triethyl ammonium salt（79570-62-0 free base) is a Nucleoside Triphosphate.

C2 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It has been used as an internal standard in the quantification of lysosulfatides in mouse brain tissue and plasma.

Nucleoside phosphonamidite；Fluoro-modified nucleosides；2’-Modified nucleosides

Ph-Bis(C1-N-(C2-NH-Boc)2) is a versatile alkyl chain-derived linker employed in the synthesis of PROTACs[1].