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Search Results for " cornea "

Targets Recommended: Sodium Channel

11

抑制剂 & 化合物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0378	Oxybuprocaine hydrochloride Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐	Sodium Channel	Membrane transporter/Ion channel
	Oxybuprocaine hydrochloride (Oxybuprocaine HCl) 是可逆的钠通道阻断剂，可防止角膜，结膜和巩膜中疼痛神经的冲动传播。Oxybuprocaine hydrochloride 专用于眼科与耳鼻喉科。
T6503	Fluorometholone Acetate NSC 47438,Flarex,Eflone,氟米龙醋酸酯,Oxylone acetate	Glucocorticoid Receptor; Carbonic Anhydrase	Endocrinology/Hormones; Metabolism
	Fluorometholone Acetate (Oxylone acetate) 是合成的糖皮质激素皮质类固醇及皮质类固醇酯。它有效抑制碳酸酐酶 (CA) 对 hCA-I(IC50:2.18 μM)和 hCA-II(IC50:17.5 μM)。它具有抗炎活性，可用于研究外部眼部炎症。
T3316	Fluorometholone 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluorometholone (Fluoromethalone) 是合成糖皮质激素，具有抗炎和抗过敏作用。它可用作糖皮质激素受体激动剂，能够用于干眼症的研究。
T37930	15(R)-17-phenyl trinor Prostaglandin F2α 15(R)-17-phenyl trinor Prostaglandin F2α	Others	Others
	17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hours. The free acid, 17-ph...
T75857	LL-37, human TFA
	LL-37, human TFA 是一种由37个氨基酸残基组成的两亲性抗菌肽，源自组织蛋白酶，具备广谱抗菌活性。该化合物有助于防护角膜避免感染，同时调节伤口的愈合过程。
T68957	Eprociclovir dihydrate	Others	Others
	Eprociclovir dihydrate is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinica...
T84647	9-keto Fluprostenol isopropyl ester	Others	Others
	9-Keto Fluprostenol Isopropyl Ester, an ester derivative of the FP receptor agonist fluprostenol, undergoes oxidation at carbon 9. This compound serves as a potential prodrug for 9-keto fluprostenol, which may function as an agonist at EP receptors. Additionally, it is considered a possible metabolite of fluprostenol isopropyl ester (travoprost), drawing parallels to the metabolism of latanoprost by 15-hydroxyprostaglandin dehydrogenase observed in monkey cornea. Furthermore, certain F-series pr...
T75858	LL-37, human acetate
	LL-37, human acetate 是一种由37个氨基酸残基组成的两亲性抗菌肽，源于组织蛋白酶的衍生物，展现出广泛的抗菌效果。该化合物不仅对角膜感染提供保护，也有助于调节伤口的愈合过程。
T69817	Eprociclovir Na	Others	Others
	Eprociclovir Na is the salt form of Eprociclovir, also known as A-5021, a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applie...
T70027	Eprociclovir potassium	Others	Others
	Eprociclovir potassium is a new acyclovir analogue and a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus. Eprociclovir possess potent anti-herpetic activity against most human herpesviruses. A-5021 proved to be about 15-fold more potent than acyclovir in inhibiting viral replication. Eprociclovir inhibits murine herpetic keratitis. A-5021 eyedrops, which are easily applied onto the affected cornea, ameliorated clinica...
T75837	Spantide I TFA
	Spantide I TFA 是substance P 的类似物，是选择性的神经激肽-1 受体 (NK1receptor) 的拮抗剂，其对NK1和NK2受体的Ki 值分别为 230 nM 和8150 nM。Spantide I 可减少感染角膜的1型细胞因子和增强2型细胞因子IL-10，从而显著减少角膜穿孔。

化合物

Oxybuprocaine hydrochloride

Cat.No: T0378

Synonym: Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐

Target: Sodium Channel

Fluorometholone Acetate

Cat.No: T6503

Synonym: NSC 47438,Flarex,Eflone,氟米龙醋酸酯,Oxylone acetate

Target: Glucocorticoid Receptor, Carbonic Anhydrase

Fluorometholone

Cat.No: T3316

Synonym: 氟米龙,Fluoromethalone,Cortilet,Oxylone,Delmeson

Target: Glucocorticoid Receptor

15(R)-17-phenyl trinor Prostaglandin F2α

Cat.No: T37930

Synonym: 15(R)-17-phenyl trinor Prostaglandin F2α

Target: Others

LL-37, human TFA

Cat.No: T75857

Eprociclovir dihydrate

Cat.No: T68957

Target: Others

9-keto Fluprostenol isopropyl ester

Cat.No: T84647

Target: Others

LL-37, human acetate

Cat.No: T75858

Eprociclovir Na

Cat.No: T69817

Target: Others

Eprociclovir potassium

Cat.No: T70027

Target: Others

Cat.No: T75837

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00680	ANGPTL7 Protein, Human, Recombinant (His) CDT6,Cornea-derived transcript 6 protein,Angiopoiet...	Human	HEK293 Cells
	Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated ...
TMPY-01680	Lumican Protein, Human, Recombinant (His) lumican,LDC,SLRR2D	Human	HEK293 Cells
	Lumican, a prototypic leucine-rich proteoglycan with keratan sulfate side chains, is a major component of the cornea, dermal, and muscle connective tissues. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican regulates collagenous matr...
TMPY-04899	OGN/Osteoglycin Protein, Human, Recombinant (His) OIF,OG,osteoglycin,SLRR3A	Human	HEK293 Cells
	OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor-beta and may regulate osteoblast differentiation. OGN is broadly expressed in the gall bladder, endometrium, and other tissues. OGN reduced Zeb-1 expression via EGFR/Akt leading to inhibition of epith...
TMPJ-01005	Lumican Protein, Mouse, Recombinant (His) KSPG lumican,Lumican,Keratan sulfate proteoglycan lumican	Mouse	HEK293 Cells
	Keratan sulfate proteoglycan lumican, mostly known as lumican, belongs to the SLRP class II subfamily and the small leucine-rich proteoglycan (SLRP) family. Lumican binds to laminin. It has positive regulation of transcription from RNA polymerase II promoter and transforming growth factor beta1 production. Lumican is expressed in a variety of tissues, including skin, artery, lung, cornea, kidney, bone, aorta, and articular cartilage. The abnormal connective tissue phenotype seen in the Lumican n...
TMPY-02117	Marapsin Protein, Human, Recombinant (His) UNQ1884/PRO4327,protease, serine 27,CAPH2,MPN	Human	HEK293 Cells
	The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most stro...
TMPJ-01432	CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated mucin 16, cell surface associated,CA-125,CA125 ovarian cance...	Human	HEK293 Cells
	MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC...
TMPY-01583	ALDH1A1 Protein, Human, Recombinant (His) ALDH11,ALDC,PUMB1,ALDH-E1,HEL-S-53e,HEL-9,aldehyde dehydroge...	Human	E. coli
	Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell function. The retinaldehyde dehydrogenase (RALDH) subfamily of ALDHs, composed of ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1, regulate development by catalyzing retinoic acid biosynthesis. The ALDH1A1 protein belongs to the aldehyde dehydrogenases f...

重组蛋白

ANGPTL7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00680

Species: Human

Expression System: HEK293 Cells

Lumican Protein, Human, Recombinant (His)

Cat.No: TMPY-01680

Species: Human

Expression System: HEK293 Cells

OGN/Osteoglycin Protein, Human, Recombinant (His)

Cat.No: TMPY-04899

Species: Human

Expression System: HEK293 Cells

Lumican Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01005

Species: Mouse

Expression System: HEK293 Cells

Marapsin Protein, Human, Recombinant (His)

Cat.No: TMPY-02117

Species: Human

Expression System: HEK293 Cells

CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated

Cat.No: TMPJ-01432

Species: Human

Expression System: HEK293 Cells

ALDH1A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01583

Species: Human

Expression System: E. coli

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