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Search Results for " cognitive disorder "

Targets Recommended: 5-HT Receptor

抑制剂 & 化合物

重组蛋白

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T8737	GR 125743	5-HT Receptor	GPCR/G Protein; Neuroscience
	GR 125743 是选择性的5-HT1B/1D 受体拮抗剂，与野生型的人 h5-HT1B 和 5-HT1D 结合的pKi 分别为 8.85 和 8.31，可用于帕金森病和心血管疾病的研究。
T2150	Guanfacine hydrochloride 盐酸胍法辛,Tenex,Intuniv,Guanfacine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂，Kd=31 nM，具有抗高血压作用。
T12054L	MK-0249 FA MK-0249 FA(862309-06-6 Free base)	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	MK-0249 FA 是一种具有口服活性、选择性和高效性的组胺 H3 反向激动剂，可用于研究成人注意力缺陷、多动症神经分裂和认知障碍。
T34752	Samelisant dihydrochloride SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl	Others	Others
	Samelisant dihydrochloride (SUVN-G3031) is a antagonist of histamine H3 receptor with potential for the treatment of cognitive impairment, dementia, attention deficit hyperactivity disorder, epilepsy, sleep disorders, obesity, schizophrenia, eating disorders, and pain.

化合物

GR 125743

Cat.No: T8737

Synonym:

Target: 5-HT Receptor

Guanfacine hydrochloride

Cat.No: T2150

Synonym: 盐酸胍法辛,Tenex,Intuniv,Guanfacine

Target: Adrenergic Receptor

MK-0249 FA

Cat.No: T12054L

Synonym: MK-0249 FA(862309-06-6 Free base)

Target: Histamine Receptor

Samelisant dihydrochloride

Cat.No: T34752

Synonym: SUVN-G3031,SUVN-G 3031,SUVN G3031,SUVN-G3031 HCl

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01114	GAMT Protein, Human, Recombinant (His) Guanidinoacetate N-methyltransferase,TP53I2,PIG2,GAMT	Human	E. coli
	GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay/regression, mental retardation, severe disturbance of ...
TMPY-04318	GRIK2 Protein, Human, Recombinant (hFc) GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...	Human	HEK293 Cells
	GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...

重组蛋白

GAMT Protein, Human, Recombinant (His)

Cat.No: TMPJ-01114

Species: Human

Expression System: E. coli

GRIK2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04318

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...

同位素标记化合物

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

Target:

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