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Search Results for " clotting "

Targets Recommended: Factor Xa

16

抑制剂 & 化合物

5

天然产物

2

化合物库

13

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name
L7500	凝血与抗凝化合物库		144 compounds
	144 个化合物的独特集合，可用于高通量筛选和高内涵筛选；
L6140	糖类及苷类化合物库		595 compounds
	595 种糖类或苷类的化合物，可用于高通量筛选和高内涵筛选；

化合物库

凝血与抗凝化合物库

Cat.No: L7500

Compounds: 144

糖类及苷类化合物库

Cat.No: L6140

Compounds: 595

Cat. No.	Product Name	Target	Signaling Pathways
T1736	Apixaban 阿哌沙班,BMS-562247-01	Factor Xa	Metabolism
	Apixaban (BMS-562247-01) 是一种高度选择性，可逆的、口服具有活力的凝血因子 Xa (Factor Xa) 抑制剂，抑制人和兔凝血因子 Xa 的 Ki 分别为 0.08 nM 和 0.17 nM。它可以用于研究各种血栓栓塞疾病。
T19786	Hematin Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid,羟高铁血红素	Others	Others
	Hematin (Ferrihemic acid) 是含铁卟啉，可以结合止血蛋白诱导其失活，降低凝血因子的活性以及阻碍纤维蛋白凝块的溶解。它可用于研究急性卟啉症和癌症。
T9999	Sirtuin modulator 2 N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) 具有抗糖尿病、抗炎和抗肿瘤活性。
T5519	Bivalirudin BG-8967,比伐卢定,Hirulog-1	Thrombin	Proteases/Proteasome
	Bivalirudin (BG-8967) 是一种直接凝血酶(thrombin)抑制剂，是一种肽类抗凝剂，可在侵入性心脏病，特别是在经皮冠状动脉介入中用于抗凝。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T6531	Heparin sodium salt 肝素钠,Sodium heparinate,Heparin sodium	Factor Xa; Thrombin; Autophagy	Autophagy; Metabolism; Proteases/Proteasome
	Heparin sodium salt (Sodium heparinate) 是一种抗凝血剂，可以干扰血凝过程中的多个环节。Heparin sodium salt 可以与抗凝血酶 III 可逆结合，加快凝血酶因子 IIa 和 Xa 的失活速度，从而发挥抗凝作用。
T23898	Clocoumarol Clocoumarolum,BRN 1264788,DB 112	Others	Others
	Clocoumarol is an anticoagulant that prevents blood clotting. It also can inhibit the dilatation of the spleen and the congestion of lymph nodes.
T26702	AZ12971554 AZ 12971554,AZ-12971554	Others	Others
	AZ12971554 is a potent inhibitor of human thrombin. Ki = 0.3nM, Activated partial thromboplastin time (APTT) IC50 = 0.68µM, Ecarin clotting time (ECT) IC50 = 0.16µM in human plasma.
T41029	Streptokinase	Others	Others
	Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blood-clotting disorders. Its application extends to enhancing reperfusion blood flow after coronary artery occlusion.
T14682	BMS-962212	Others	Others
	BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated partial thromboplastin time and decreases FXI clotting activity exposure [1].
TP1129	Boc-Ile-Glu-Gly-Arg-AMC IEGR-AMC
	Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC), a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi.
T28491	R-1663 R1663	Others	Others
	R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner without increasing bleeding time. Pharmac
T83717	Cys-Pexiganan TFA
	Cys-pexiganan是一种抗微生物肽，是pexiganan的衍生物，具有N-末端的半胱氨酸。它对P. aeruginosa和S. aureus具有活性（MICs分别为64和16 µg/ml）。Cys-pexiganan与含醋酸纤维素的聚乙烯醇电纺垫结合，可以加速隔离的重钙化人类血浆的凝血。
T26657	AR-H067637	Others	Others
	AR-H067637 is a rapid-binding, reversible and potent (inhibition constant K(i) = 2-4 nM), competitive inhibitor of thrombin, as well as of thrombin bound to fibrin (clot-bound thrombin) or to thrombomodulin. The total amount of free thrombin generated in
T75152	ARC19499	Others	Others
	ARC19499 是一种核酸适配体，与组织因子通路抑制剂(TFPI)特异性结合，阻断 TFPI 对factor Xa 和 TF/factor VIIa 复合物的抑制作用。ARC19499 纠正血友病A 和B 血浆中的凝血酶生成，并恢复凝血。
T74672	Sirtuin modulator 5	Others	Others
	Sirtuinmodulator 5 是一种sirtuin 调节剂。Sirtuinmodulator 5 可以激活SIRTl，DC50值 <50 μM。Sirtuinmodulator 5 可用于增加细胞的寿命并用于研究多种疾病，包括例如与衰老或压力、糖尿病、肥胖症、神经退行性疾病、心血管疾病、凝血障碍、炎症、癌症和/或潮红以及将受益于线粒体活性增加的疾病或病症。

化合物

Cat.No: T1736

Synonym: 阿哌沙班,BMS-562247-01

Target: Factor Xa

Cat.No: T19786

Synonym: Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid,羟高铁血红素

Target: Others

Sirtuin modulator 2

Cat.No: T9999

Synonym: N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide

Target: Others, Sirtuin

Cat.No: T5519

Synonym: BG-8967,比伐卢定,Hirulog-1

Target: Thrombin

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Heparin sodium salt

Cat.No: T6531

Synonym: 肝素钠,Sodium heparinate,Heparin sodium

Target: Factor Xa, Thrombin, Autophagy

Cat.No: T23898

Synonym: Clocoumarolum,BRN 1264788,DB 112

Target: Others

Cat.No: T26702

Synonym: AZ 12971554,AZ-12971554

Target: Others

Cat.No: T41029

Target: Others

Cat.No: T14682

Target: Others

Boc-Ile-Glu-Gly-Arg-AMC

Cat.No: TP1129

Synonym: IEGR-AMC

Cat.No: T28491

Synonym: R1663

Target: Others

Cys-Pexiganan TFA

Cat.No: T83717

Cat.No: T26657

Target: Others

Cat.No: T75152

Target: Others

Sirtuin modulator 5

Cat.No: T74672

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1607	Hydrastinine hydrochloride 北美黄连碱分碱盐酸盐,北美黄连碱分碱	Others	Others
	Hydrastinine hydrochloride 是金印草中的一种主要生物碱成分，可用作止血剂。
T5742	Isodemethylwedelolactone 异去甲蟛蜞菊内酯,Isodemethylwedelolacton	Others	Others
	Isodemethylwedelolactone (Isodemethylwedelolacton) 是一种促凝剂，也是溶血性成分，分离自 Eclipta alba。
T0465	Ellagic acid 鞣花酸,Gallogen,Elagostasine	Hedgehog/Smoothened; Casein Kinase; Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; PKA; Syk; PKC; Carbonic Anhydrase	Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Ellagic acid (Gallogen) 是从 Eucalyptus maculata Hook 和 E. Hemipholia F. Muell 的 kino 中分离出来的稠合四环天然产物，是一种有效的，ATP 竞争性的CK2抑制剂，IC50和Ki 值分别为 40 nM 和 20 nM。
T0809	Dicoumarol Dicumarol,双羟香豆素,双香豆素	Dehydrogenase; NADPH; PDK	Metabolism; PI3K/Akt/mTOR signaling
	Dicoumarol (Dicumarol) 是一种 NAD(P)H: 醌氧化还原酶 1 和PDK1的抑制剂，它们的IC50值分别为 0.37 和 19.42 μM。
T21296	Desmopressin acetate trihydrate Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine
	Desmopressin acetate is a synthetic replacement for vasopressin, which reduces urine production. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) diabetes insipidus; (c) nighttime urination; (d) clotting disorders.

天然产物

Hydrastinine hydrochloride

Cat.No: T1607

Synonym: 北美黄连碱分碱盐酸盐,北美黄连碱分碱

Target: Others

Isodemethylwedelolactone

Cat.No: T5742

Synonym: 异去甲蟛蜞菊内酯,Isodemethylwedelolacton

Target: Others

Cat.No: T0465

Synonym: 鞣花酸,Gallogen,Elagostasine

Target: Hedgehog/Smoothened, Casein Kinase, Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, PKA, Syk, PKC, Carbonic Anhydrase

Cat.No: T0809

Synonym: Dicumarol,双羟香豆素,双香豆素

Target: Dehydrogenase, NADPH, PDK

Desmopressin acetate trihydrate

Cat.No: T21296

Synonym: Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00346	Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His) Limulus clotting factor C	Carcinoscorpius rotundicauda	E. coli
	This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of factor B. Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 42.2 kDa and the accession number is Q26422.
TMPH-03618	Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc) FC,Limulus factor C,Clotting factor C	Tachypleus tridentatus	E. coli
	This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of clotting factor B. Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.8 kDa and the accession number is P28175.
TMPH-03163	SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc) Habutobin,Snake venom serine protease 1,Fibrinogen-clott...	Protobothrops flavoviridis	E. coli
	SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.1 kDa and the accession number is P05620.
TMPH-00038	Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) Snake venom serine protease,Thrombin-like enzyme contortrixo...	Agkistrodon contortrix	E. coli
	Thrombin-like snake venom serine protease that cleaves beta chain of fibrinogen (FGB), releasing fibrinopeptide B. Has a coagulant activity activating blood coagulation factors V (F5) and XIII (F13A1). Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.4 kDa and the accession number is P82981.
TMPH-00324	SVTLE Protein, Calloselasma rhodostoma, Recombinant (His) Thrombin-like enzyme ancrod,Snake venom serine protease,Fibr...	Calloselasma rhodostoma	P. pastoris (Yeast)
	SVTLE Protein, Calloselasma rhodostoma, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 28.6 kDa and the accession number is P26324.
TMPH-00768	SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc) Calobin I,Snake venom serine protease,Fibrinogen-clottin...	Gloydius ussuriensis	E. coli
	Thrombin-like snake venom serine protease. Has a coagulant activity. Acts on alpha-chains of fibrinogen (FGA) generating fibrinopeptide A. SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.7 kDa and the accession number is Q91053.
TMPH-00215	SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) Venombin A,Fibrinogen-clotting enzyme,Snake venom s...	Bothrops jararaca	E. coli
	Thrombin-like snake venom serine protease that clots fibrinogen by releasing fibrinopeptide A from the alpha chain of fibrinogen (FGA), induces platelet aggregation through its interaction with GPIb (GP1BA/GP1BB), and activates factor VIII (F8). SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is P81661.
TMPY-01101	Coagulation factor X/F10 Protein, Human, Recombinant (His) FXA,FX,coagulation factor X,coagulation factor 10	Human	Baculovirus Insect Cells
	Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema...
TMPK-00204	FGL1 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated Hepassocin,Lag3 ligand,HP-041,LFIRE-1,HFREP1,FGL1,HFREP-1,FG...	Human	HEK293 Cells
	Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene.Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII.Fibrinogen-like Protein 1 is a major immune inhibitory ligand of LAG-3.
TMPJ-00502	Serpin G1 Protein, Human, Recombinant (His) C1-Inhibiting Factor,Serpin G1,SERPING1,C1 Esterase Inhibito...	Human	HEK293 Cells
	As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein. It is the largest member among the serpin class of proteins. Remarkably, Serpin G1 has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of Serpin G1 provides the inhibitory activity. The N-terminal domain ...
TMPJ-00301	Coagulation Factor X Protein, Human, Recombinant (hFc) Stuart-Prower factor,Stuart factor,Coagulation factor X	Human	HEK293 Cells
	F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways activate Factor X to Xa, which consists of light (residues 41‑179) and heavy (residues 235‑488) chains linked by a disulfide bond. Coagulation factor X is initially synthesized in the liver. The two chains are formed from a single-chain precursor by the excision of two Arg residue...
TMPJ-00707	Coagulation factor X/F10 Protein, Mouse, Recombinant (His) Stuart factor,Coagulation factor X,F10	Mouse	HEK293 Cells
	Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin K-dependent plasma protease that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. The two chains of F10 are formed from a single-chain precursor by the excision of two Arg residues. A single-chain precursor is initiall...
TMPJ-00734	KNG1 Protein, Human, Recombinant (His) KNG1,High Molecular Weight Kininogen,BDK,HMWK,KNG,Williams-F...	Human	HEK293 Cells
	Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role in blood coagulation and inflammatory response. Kininogens are inhibitors of thiol proteases. Kininogen-1 participates in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, also inhibits the thrombin- and plasmin-induced aggregation...

重组蛋白

Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His)

Cat.No: TMPH-00346

Species: Carcinoscorpius rotundicauda

Expression System: E. coli

Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc)

Cat.No: TMPH-03618

Species: Tachypleus tridentatus

Expression System: E. coli

SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc)

Cat.No: TMPH-03163

Species: Protobothrops flavoviridis

Expression System: E. coli

Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc)

Cat.No: TMPH-00038

Species: Agkistrodon contortrix

Expression System: E. coli

SVTLE Protein, Calloselasma rhodostoma, Recombinant (His)

Cat.No: TMPH-00324

Species: Calloselasma rhodostoma

Expression System: P. pastoris (Yeast)

SVTLE Protein, Gloydius ussuriensis, Recombinant (His & Myc)

Cat.No: TMPH-00768

Species: Gloydius ussuriensis

Expression System: E. coli

SVTLE Protein, Bothrops jararaca, Recombinant (His & Myc)

Cat.No: TMPH-00215

Species: Bothrops jararaca

Expression System: E. coli

Coagulation factor X/F10 Protein, Human, Recombinant (His)

Cat.No: TMPY-01101

Species: Human

Expression System: Baculovirus Insect Cells

FGL1 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00204

Species: Human

Expression System: HEK293 Cells

Serpin G1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00502

Species: Human

Expression System: HEK293 Cells

Coagulation Factor X Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00301

Species: Human

Expression System: HEK293 Cells

Coagulation factor X/F10 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00707

Species: Mouse

Expression System: HEK293 Cells

KNG1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00734

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0001	Vitamin K1-d4
	Vitamin K1-d4 是 Vitamin K1 的氘代化合物。Vitamin K1 的 CAS 号为 84-80-0。Vitamin K1 (Phylloquinone) 是天然存在的维生素。Vitamin K1是血液凝固，骨和血管代谢所必须的。

同位素标记化合物

Cat.No: TMID-0001

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