clonidine

Clonidine (Kapvay) 是 alpha2 肾上腺素能激动剂。

Clonidine hydrochloride (Catapres) 是一种α2-adrenoceptor 激动剂，是一种抗高血压药。

Clonidine-d4 Hydrochloride 是 Clonidine Hydrochloride 的氘代化合物。Clonidine Hydrochloride 的 CAS 号为 4205-91-8。Clonidine hydrochloride 是一种α2-adrenoceptor激动剂，是一种抗高血压药。

Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的，具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂，能够扩张使血管，降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压，心力衰竭和勃起功能障碍。

Apraclonidine hydrochloride (ALO 2145) 是一种 α2-肾上腺素能激动剂和弱的 α-1 肾上腺素能受体激动剂。 Apaclonidine hydrochloride 可降低人眼的眼内压，可用于青光眼治疗的研究。

Unifiram 是一种认知增强剂。 Unifiram 诱导大鼠海马 CA1 区场兴奋性突触后电位 (fEPSP) 幅度的持久增加 (EC50= 27 nM) 并增加大鼠大脑皮层中乙酰胆碱 (ACh) 的释放。

Piclonidine is a bioactive chemical.

Apraclonidine (ALO 2145) 是一种选择性α2和弱 α1 受体激动剂，可有效降低人眼的眼内压。Apraclonidine 也是一种局部滴眼液。

Apraclonidine (ALO 2145) dihydrochloride is a selective α2 and weak α1 receptor agonist that effectively reduces intraocular pressure (IOP) in the eyes. It is available as a topical ophthalmic solution [1] [2].

Wy 27127 is an alpha 2-adrenoceptors antagonist that has estimated potency based on ability to block clonidine-induced inhibition of electrically-evoked contractions of the rat isolated vas deferens.

Medetomidine(Domtor)是一种有效的、高选择性的、具有口服活性的α2肾上腺素受体激动剂，对α2和α1肾上腺素受体的 Ki 值分别为1.08 nM 和1750 nM。

Moxonidine Hydrochloride is a selective agonist at the imidazoline receptor subtype 1, used as antihypertensive agent. Target: I1-R Moxonidine Hydrochloride is a centrally acting antihypertensive agent. Mixed Nischarin (I1 imidazoline receptor) and α2-AR (adrenergic) agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors. Moxonidine reduced stimulated NE overflow (log EC50: -6.15 + - 0.14). AGN192403, a selective ligand at I1-R, had no influence on the dose-response curve of moxonidine (log EC50: -6.01 + - 0.25). The hypotensive and bradycardic actions of moxonidine but not clonidine are mediated through imidazoline receptors and are dependent on intact noradrenergic pathways within the RVLM. Furthermore, the noradrenergic innervation may be associated with a 42 kDa imidazoline receptor protein.

The alpha-adrenoceptors blocking effect of (N-piperidinomethyl)-2-chromanne was studied in vivo and in vitro in the rat. In the pithed rat, (N-piperidinomethyl)-2-chromanne (1 mg/kg i.v.) antagonized the pressor effects induced by alpha agonists. (N-piperidinomethyl)-2-chromanne competitively antagonized the pressor effects of M7 (alpha 2-agonist) and cirazoline (alpha 1-agonist). (N-piperidinomethyl)-2-chromanne antagonized the inhibitory effects of clonidine on presynaptic alpha 2-receptors in stimulated pithed rats.

Napamezole is an α2 adrenergic receptor antagonist. Napamezole antagonizes methoxamine-induced contractions (alpha-1) of the rat vas deferens with a Kb of 135 nM. Napamezole reverses clonidine-induced decreased in twitch height in the electrically stimula