ciap-1 ligand-linker conjugates 6 hydrochloride

cIAP1 Ligand-Linker Conjugates 6 hydrochloride is a compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized for the purpose of designing SNIPERs[1].

PROTAC BRD4 ligand-1 是 PROTAC GNE-987 靶向 BRD4 蛋白的配体，也是一种 BET 的抑制剂。

1-Bromo-6-chlorohexane (Hexane, 1-bromo-6-chloro-) 用作 PROTAC linker。

SMARCA-BD ligand 1 for Protac 能够与 BAF ATPase 亚基 SMARCA2 结合，可用于 PROTAC 技术，用于降解 SMARCA2。

SMARCA-BD ligand 1 for Protac dihydrochloride 是一种能够与 BAF ATPase 亚基 SMARCA2 结合的化合物，基于 PROTAC 技术，使 SMARCA2 降解。

PROTAC ERRα ligand 1 是一种雌激素相关受体 α (ERRα) 拮抗剂，能够作用于 ERRα (IC50:0.04 μM)和 ERRγ (IC50:2.8 μM)。

TEAD ligand 1 是一种结合靶蛋白TEAD的配体，可用于合成PROTAC[TEAD degrader-1]。

E3 Ligase Ligand-linker Conjugate 5 由 Thalidomide 和相对应的 Linker 组成，是一种 E3 连接酶配体与连接子的结合体。它可作为 Cereblon 配体来招募 CRBN 蛋白，同时在完整 PROTACs 分子合成中充当关键的中间体。

E3 Ligase Ligand-linker Conjugate 48为E3泛素连接酶配体-Linker结合物，主要应用于PROTACs分子的合成。

TSPO ligand-1 对外周和中枢苯二氮卓受体有亲和力。TSPO ligand-1 是一种线粒体外膜跨膜结构域上与 AUTAC4 结合的蛋白，可诱导线粒体自噬 (autophagy) 促进胞内线粒体更新。TSPO ligand-1 参与胆固醇在胞内的转运，可作为脑损伤和神经变性的生物标志物。

PROTACBcl-xL ligand-1 是Bcl-xL 的配体，可用于PROTAC 的合成。

2-(2-(6-chlorohexyloxy)ethoxy)ethanamine hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64585。

K-Ras ligand-Linker Conjugate 6 is a chemical compound that combines a ligand for K-Ras recruiting moiety and a PROTAC linker. This compound can recruit E3 ligases, including VHL, CRBN, MDM2, and IAP. K-Ras ligand-Linker Conjugate 6 is particularly useful in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 5 is a chemical compound that combines a ligand for the K-Ras recruiting moiety with a PROTAC linker. This linker is responsible for recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. The K-Ras ligand-Linker Conjugate 5 plays a crucial role in the synthesis of PROTAC K-Ras Degrader-1, a highly potent K-Ras degrader. In SW1573 cells, this degrader exhibits an impressive degradation efficacy of ≥70% [1].

cIAP1 Ligand-Linker Conjugates 9 feature an IAP ligand specifically targeting the E3 ubiquitin ligase, along with a PROTAC linker. It is valuable tools for developing SNIPERs[1].

CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.

MAC glucuronide linker-1 is a noncleavable ADC linker used in antibody-drug conjugations (ADCs).

FAK ligand-Linker Conjugate 1 is a chemical compound designed to facilitate PROTAC-mediated protein degradation. This compound consists of a ligand specifically targeting FAK and a PROTAC linker module, which acts as a recruitment agent for E3 ligases including VHL, CRBN, MDM2, and IAP[1].

DENV ligand 1，作为DENV E蛋白的配体，可应用于合成PROTAC降解剂ZXH-8-004。

TYK2ligand 1 是一种用于合成 TYK2PROTAC降解剂 (CPD-155) 的 TYK2 配体。

E3 Ligase Ligand-linker Conjugate 28是E3连接酶配体与连接子的缀合物 (E3 Ligase Ligand-Linker Conjugates)，由Thalidomide和对应Linker构成。E3 Ligase Ligand-linker Conjugate 28可作为Cereblon配体募集CRBN蛋白，并作为关键中间体进行完整PROTACs分子合成。

E3 Ligase Ligand-linker Conjugate 45 是由 Thalidomide 和对应 Linker 构成的 E3 连接酶配体与连接子的缀合物。它能作为 Cereblon 配体募集 CRBN 蛋白，并在 PROTACs 分子合成中充当关键中间体。

E3 Ligase Ligand-linker Conjugate 50 为一种 (E3 Ligase Ligand-Linker Conjugates) 的缀合物，其由 (S,R,S)-AHPC 和相应的 Linker 构成。其中，(S,R,S)-AHPC 作为基于 VH032 的 von Hippel-Lindau (VHL) 配体，能够募集 VHL 蛋白。此缀合物主要用作合成完整 PROTACs 分子的关键中间体。

E3 Ligase Ligand-linker Conjugate 51 是一种将 Thalidomide 和相应的 Linker 结合形成的配体-连接子缀合物 (E3 Ligase Ligand-Linker Conjugates)。该化合物能够作为 Cereblon 配体招募 CRBN 蛋白，并作为合成完整 PROTACs 分子的关键中间体。

E3 Ligase Ligand-linker Conjugate 58为Thalidomide与对应Linker构成的E3连接酶配体与连接子缀合物(E3 Ligase Ligand-Linker Conjugates)。该化合物能够作为Cereblon配体，募集CRBN蛋白，并用于PROTACs分子的关键中间体合成。

BRD4 Ligand-Linker Conjugate 1 is a compound consisting of a ligand and a linker, specifically designed to bind to the target protein BRD4. This conjugate serves as a valuable tool for synthesizing PROTACs, molecules utilized for targeted protein degradation.

CCK2R Ligand-Linker Conjugate 1 is a hydrophilic peptide linker that conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) as ligand-linker conjugates[1].

CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM

K-Ras ligand-Linker Conjugate 1 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker, facilitating the recruitment of E3 ligases VHL, CRBN, MDM2, and IAP. It can be utilized in the synthesis of PROTAC K-Ras Degrader-1, a highly effective K-Ras degrader that achieves ≥70% degradation efficacy in SW1573 cells[1].

VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1].

cIAP1 Ligand-Linker Conjugates 5 is a chemical compound consisting of an IAP ligand that targets the E3 ubiquitin ligase, and a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 5, is specifically designed for the development of SNIPERs[1].

TSPO Ligand-Linker Conjugates 1，包含TSPO配体和连接子，用于合成靶向线粒体的AUTAC。该AUTAC能与OMM上TSPO结合，通过mitophagy降解受损线粒体和蛋白质，提升线粒体活性。适用于研究线粒体功能紊乱，包括神经退行性疾病、癌症和糖尿病。

E3 Ligase Ligand-linker Conjugate 54 是由Thalidomide和对应Linker组成的E3连接酶配体与连接子的复合物。它能够作为Cereblon配体招募CRBN蛋白，并在PROTACs分子合成中充当关键中间体。

PROTACPARP EGFR ligand 1 是一种活性化合物，可通过蛋白水解靶向嵌合体（PROTAC）技术用于合成双 PARPEGFR 降解剂的合成。

HEMTAC CDK4 6 degrader 1 是一种通过连接HSP90的配体和CDK4 6而形成的PROTAC，其Kd值为35.7 µM。在B16F10黑色素瘤细胞中，该化合物能够诱导CDK4 6的降解，从而将细胞周期阻滞在G0 G1期，并引发细胞凋亡。因此，HEMTAC CDK4 6 degrader 1可被应用于癌症研究领域。

PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs.

cIAP1 ligand 1 (E3 ligase Ligand 12) 是基于 LCL161 衍生物的细胞凋亡蛋白配体，可募集 IAP 泛素连接酶以降解靶蛋白，可用于和雄激素受体配体欧联开发蛋白降解剂，可用于研究前列腺癌。

PROTAC BCR-ABL1 ligand 1 is the ligand of PROTAC .

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound that consists of a ligand for K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential in the synthesis of PROTAC K-Ras Degrader-1, a potent PROTAC K-Ras degrader that demonstrates a degradation efficacy of ≥70% in SW1573 cells[1].

cIAP1 Ligand-Linker Conjugates 15 consists of an IAP ligand that targets the E3 ubiquitin ligase, along with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 15, is suitable for the development of SNIPERs[1].

PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.

ERRα Ligand-Linker Conjugates 1 refers to a chemical compound that consists of a ligand targeting estrogen-related receptor alpha (ERRα), and a PROTAC linker that facilitates the recruitment of E3 ligases MDM2. It finds utility in the synthesis of a range of PROTACs, including one known as PROTAC ERRalpha Degrader-1. With its capability to induce degradation of ERRα, PROTAC ERRalpha Degrader-1 functions as an ERRα degrader[1].

K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively.

cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10.

cIAP1 Ligand-Linker Conjugates 8 comprises an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. This compound is specifically utilized for the purpose of SNIPER design[1].

cIAP1 Ligand-Linker Conjugates 13, containing an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker, are utilized in the development of SNIPERs[1].

cIAP1 Ligand-Linker Conjugates 2 Hydrochloride is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is utilized in the creation of SNIPERs[1].