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Search Results for " chitinase "

Targets Recommended: Others

17

抑制剂 & 化合物

1

天然产物

14

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T73612	Chitinase	Others	Others
	Chitinase 具有部分具有溶菌酶活性，广泛存在于细菌、真菌、动物和一些植物中。Chitinase 属于糖基水解酶家族大豆几丁质酶催化壳寡糖水解。
T10788L	Chitinase-IN-2 hydrochloride Chitinase-IN-2 hydrochloride (1579991-63-1 free base)	Others	Others
	Chitinase-IN-2 hydrochloride 是昆虫几丁质酶抑制剂和N-乙酰氨基己糖苷酶抑制剂。
T10788	Chitinase-IN-2	Others	Others
	Chitinase-IN-2 is an insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide.
T10787	Chitinase-IN-1	Others	Others
	Chitinase-IN-1 is an insect chitinase and N- acetyl hexosaminidase inhibitor and pesticide.
T62069	Chitinase-IN-4	Others	Others
	Chitinase-IN-4 (compound 8f) 是一种有效的、选择性的 OfChi-h 抑制剂，其 IC50 值为 0.1 μM，具有良好的杀虫作用。
T62122	Chitinase-IN-5	Others	Others
	Chitinase-IN-5 (8i) 是一种几丁质酶OfChi-h 的有效抑制剂 (IC50: 0.051 μM)，具有良好的杀虫作用。Chitinase-IN-5 能够用于研究绿色害虫防治和管理。
T9592	OATD-01	Others	Others
	OATD-01 是一种壳三糖苷酶及酸性哺乳动物几丁质酶的高活性抑制剂，对CHIT1具有低纳摩尔活性 (hCHIT1,IC50=23 nM)。它在多个物种中显示出良好的药代动力学特征，在体内具有显著的抗纤维化活性，可用于研究肺纤维化。
T6452	Closantel Sodium	Antibacterial; Parasite	Microbiology/Virology
	Closantel sodium 是抗寄生虫活性的卤化水杨酰苯胺。它是高度特异性的盘尾丝虫几丁质酶抑制剂。
T0237	Closantel 氯氰碘柳胺,R-31520,氯生太尔	Antibacterial; Parasite	Microbiology/Virology
	Closantel (R-31520) 是抗寄生虫活性的卤化水杨酰苯胺。它是高度特异性盘尾丝虫几丁质酶抑制剂。
T40863	Bisdionin C	Antibacterial	Microbiology/Virology
	Bisdionin C 是一种有效的 GH18 chitinase 抑制剂，对 A. fumigatus ChiB1 的 IC50 为 0.2 μM。 Bisdionin C 抑制人巨噬细胞壳三糖苷酶 (HCHT, IC50 = 8.3 μM) 和酸性哺乳动物几丁质酶 (AMCase, IC50 = 3.4 μM)。
T26595	Allosamidin A-82516,A 82516,A82516	Others	Others
	Allosamidin, a chitinase inhibitor and typical secondary metabolite of Streptomyces, may be used as a pesticide and anti-asthmatic agent.
TP2140	Argifin	Others	Others
	Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms (IC50: 0.025 μM, 6.4 μM, 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase).
T70177	OAT-177	Others	Others
	OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor.
T76261	Argadin
	Argadin 是一种环五肽几丁质酶抑制剂。Argadin 抑制几丁质酶 B (ChiB)，Ki 值为 20 nM。Argadin 可用于杀菌剂和杀虫剂的研究。
T40961	Lynamicin B	Others	Others
	Lynamicin B, a promising pesticide, functions as a selective chitinase inhibitor exclusive to lepidoptera. It exhibits a Ki value of 8.76 μM, indicating its potential efficacy.
T80723	ZK-PI-9	Others	Others
	ZK-PI-9 是一种抑制海藻糖酶且能够抑制雌性蛹中几丁质酶活性的杀虫剂。
T83779	EP4 Antagonist 14 Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14是一种前列腺素E2（PGE2）受体亚型EP4的拮抗剂，其在使用表达人源受体的HEK293细胞的报告基因测定中的IC50值为1.1 nM。它还能抑制PGE2诱导的同种细胞中的β-阿雷斯汀招募（IC50 = 0.9 nM）。EP4 antagonist 14（10 µM）能减少RAW 264.7巨噬细胞中PGE2诱导的mRNA表达，这些mRNA编码Il-4、巨噬细胞甘露糖受体1（Mrc1）、几丁质酶样蛋白3（Chil3）、趋化因子（C-X-C）基序配体1（Cxcl1）、表达在髓样细胞上的触发受体2（Trem2）和精氨酸酶-1（Arg1）。在体内，EP4 antagonist 14（每天30 mg/kg），结合抗PD-1抗体，能够在CT26小鼠结肠癌模型中抑制肿瘤生长并增加CD8+ T细胞对肿瘤的浸润。

化合物

Cat.No: T73612

Target: Others

Chitinase-IN-2 hydrochloride

Cat.No: T10788L

Synonym: Chitinase-IN-2 hydrochloride (1579991-63-1 free base)

Target: Others

Chitinase-IN-2

Cat.No: T10788

Target: Others

Chitinase-IN-1

Cat.No: T10787

Target: Others

Chitinase-IN-4

Cat.No: T62069

Target: Others

Chitinase-IN-5

Cat.No: T62122

Target: Others

Cat.No: T9592

Target: Others

Closantel Sodium

Cat.No: T6452

Target: Antibacterial, Parasite

Cat.No: T0237

Synonym: 氯氰碘柳胺,R-31520,氯生太尔

Target: Antibacterial, Parasite

Cat.No: T40863

Target: Antibacterial

Cat.No: T26595

Synonym: A-82516,A 82516,A82516

Target: Others

Cat.No: TP2140

Target: Others

Cat.No: T70177

Target: Others

Cat.No: T76261

Cat.No: T40961

Target: Others

Cat.No: T80723

Target: Others

EP4 Antagonist 14

Cat.No: T83779

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

Cat. No.	Product Name	Target	Signaling Pathways
T38561	Chitopentaose pentahydrochloride	Others	Others
	Chitopentaose pentahydrochloride is an anti-inflammatory chitosan oligosaccharide that functions as a substrate for the gene encoding chitinase B (FjchiB).

天然产物

Chitopentaose pentahydrochloride

Cat.No: T38561

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02500	YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) Gp39,AW208766,Brp39,chitinase 3 like 1	Mouse	HEK293 Cells
	YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2.
TMPY-01304	YKL-40/CHI3L1 Protein, Human, Recombinant (His) YKL-40,CGP-39,HC-gp39,GP39,DKFZp686N19119,HCGP-3P,GP-39,...	Human	HEK293 Cells
	YKL-40/CHI3L1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is A0A024R969.
TMPH-03738	Endochitinase B Protein, Zea mays, Recombinant (His & Myc) ChitB,CHIB,Endochitinase B,Seed chitinase ...	Zea mays	E. coli
	Defense against chitin-containing fungal pathogens.
TMPY-01290	CHIT1 Protein, Human, Recombinant (His) chitinase 1 (chitotriosidase),CHITD,CHI3,CHIT	Human	HEK293 Cells
	Chitotriosidase, also known as Chitinase-1 and CHIT1, is a member of the glycosyl hydrolase 18 family and Chitinase class II subfamily. It is a member of the mammalian chitinase family, structurally homologous to chitinases from other species, is synthesized and secreted by specifically activated macrophages. Chitotriosidase is a polymer of N-acetylglucosamine. Serum and plasma chitotriosidase activity is usually measured as the first step in diagnosis of Gaucher disease. Monitoring chitotriosid...
TMPH-01083	CHID1 Protein, Human, Recombinant (His) GL008,SI-CLP,SB139,Chitinase domain-containing prot...	Human	E. coli
	Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). CHID1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9BWS9.
TMPH-02578	CHI3L4 Protein, Mouse, Recombinant (His) Chil4,Secreted protein Ym2,Ym2,Chitinase-3-like pro...	Mouse	P. pastoris (Yeast)
	Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity.
TMPK-01127	AMCase/CHIA Protein, Mouse, Recombinant (His) CHIT2,Chia1,AMCase,YNL,Acidic mammalian chitinase,C...	Mouse	HEK293 Cells
	Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases. The expression of AMCase and CHIT-1 were differently modulated in HMMs at different stage of maturation.
TMPH-02577	CHID1 Protein, Mouse, Recombinant (His & Myc) Stabilin-1-interacting chitinase-like protein,CHID1...	Mouse	HEK293 Cells
	Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).
TMPY-01933	CHI3L2 Protein, Human, Recombinant (His) YKL-39,CHIL2,chitinase 3 like 2,YKL39	Human	HEK293 Cells
	Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in b...
TMPK-01154	AMCase/CHIA Protein, Human, Recombinant (His) YNL,AMCase,Chia1,CHIA,Acidic mammalian chitinase,EC...	Human	HEK293 Cells
	Acidic mammalian chitinase (AMCase) and chitotriosidase (CHIT-1) are two active chitinases expressed in humans. The chitinase activity of AMCase was found to be causative in allergic inflammation and its expression was found to be induced by interleukin-13. CHIT1-1 is expressed by phagocytic cells and extremely high levels are seen in lysosomal storage diseases. Despite that AMCase expression in the inflammation is under investigation, little is known regarding its regulation during macrophages'...
TMPY-00603	YM1/Chitinase 3 Like 3 Protein, Mouse, Recombinant (His) Ym1	Mouse	HEK293 Cells
	YM1/Chitinase 3 Like 3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.8 kDa and the accession number is O35744.
TMPH-03266	CHI3L1 Protein, Rat, Recombinant (His) Chi3l1,Cartilage glycoprotein 39,CGP-39,GP-39,Chitinase<...	Rat	E. coli
	Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mu...
TMPH-00135	Endochitinase Protein, Avena sativa, Recombinant (His)	Avena sativa	E. coli
	This protein functions as a defense against chitin-containing fungal pathogens. Endochitinase Protein, Avena sativa, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 25.7 kDa and the accession number is P86181.
TMPH-02468	Mo-CBP3 Protein, Moringa oleifera, Recombinant (GST) Chitin-binding protein 3	Moringa oleifera	E. coli
	Chitin-binding protein. Has antifungal activity against F.solani, F.oxysporum, C.musae and C.gloesporoides but not against P.oligandrum. Depending on concentration the antifungal activity can be fungistatic or fungicidal. Inhibits both spore germination and mycelial growth in F.solani at a concentration of 0.1 mg/ml. Has antifungal activity against C.krusei, C.albicans, C.tropicalis and C.parapsilosis. Has no chitinase, beta-glucanase or hemagglutinating activity. Acts as a flocculent. Mo-CBP3 P...

重组蛋白

YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02500

Species: Mouse

Expression System: HEK293 Cells

YKL-40/CHI3L1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01304

Species: Human

Expression System: HEK293 Cells

Endochitinase B Protein, Zea mays, Recombinant (His & Myc)

Cat.No: TMPH-03738

Species: Zea mays

Expression System: E. coli

CHIT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01290

Species: Human

Expression System: HEK293 Cells

CHID1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01083

Species: Human

Expression System: E. coli

CHI3L4 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02578

Species: Mouse

Expression System: P. pastoris (Yeast)

AMCase/CHIA Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01127

Species: Mouse

Expression System: HEK293 Cells

CHID1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02577

Species: Mouse

Expression System: HEK293 Cells

CHI3L2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01933

Species: Human

Expression System: HEK293 Cells

AMCase/CHIA Protein, Human, Recombinant (His)

Cat.No: TMPK-01154

Species: Human

Expression System: HEK293 Cells

YM1/Chitinase 3 Like 3 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00603

Species: Mouse

Expression System: HEK293 Cells

CHI3L1 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03266

Species: Rat

Expression System: E. coli

Endochitinase Protein, Avena sativa, Recombinant (His)

Cat.No: TMPH-00135

Species: Avena sativa

Expression System: E. coli

Mo-CBP3 Protein, Moringa oleifera, Recombinant (GST)

Cat.No: TMPH-02468

Species: Moringa oleifera

Expression System: E. coli

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