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Targets Recommended: Estrogen/progestogen Receptor

23

抑制剂 & 化合物

9

天然产物

1

化合物库

7

重组蛋白

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Cat. No.	Product Name
L6120	黄酮类天然产物库		514 compounds
	514 种黄酮类天然产物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

黄酮类天然产物库

Cat.No: L6120

Compounds: 514

Cat. No.	Product Name	Target	Signaling Pathways
T13507	4,4'-Iminodiphenol 4-(4-羟基苯胺)苯酚,Leucoindophenol	Estrogen/progestogen Receptor	Endocrinology/Hormones
	4,4'-Iminodiphenol (Leucoindophenol) 是基于二苯胺骨架的无活性雌激素受体配体。
T77504	JAK1/2/3 Inhibitor 1	PKA	Tyrosine Kinase/Adaptors
	JAK1/2/3 Inhibitor 1 是一种有效的蛋白激酶抑制剂。2,4-dichlorothieno[3,2-d]pyrimidine 具有抗肿瘤活性可抑制多种癌细胞株的生长。它通过与癌细胞的骨架结合，抑制新蛋白质的生成，从而抑制癌细胞的生长。
T38896	VPM peptide
	VPM peptide functions as a protease-cleavable dithiol cross-linker. It is capable of integration into the PEG-diacrylate (PEG-DA) macromer backbone, resulting in the formation of PEG hydrogel.
T15993	Mal-PEG4-PFP ester	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Mal-PEG4-PFP ester is a non-cleavable antibody-drug conjugate (ADC) linker that incorporates a Maleimide moiety, a 4-unit Polyethylene Glycol (PEG) backbone, and a Pentafluorophenyl (PFP) ester.
T76708	Penpulimab
	Penpulimab 是一种IgG1抗PD-1单克隆抗体，具有抗肿瘤活性。
T18488	NH2-MPAA-NODA	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	NH2-MPAA-NODA, a nitroveratryl-based photocleavable linker featuring a NODA motif and a methyl phenyl acetic acid (MPAA) backbone, serves as a radiolabel when labeled with 18F-fluoride.
T16591	Propargyl-PEG1-SS-PEG1-PFP ester	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Propargyl-PEG1-SS-PEG1-PFP ester is a cleavable linker consisting of a 1-unit polyethylene glycol (PEG) backbone, designed for use in the synthesis of antibody-drug conjugates (ADCs)[1].
T34686	Sonoflora 1 SF 1,SF-1,Sonoflora1,Sonoflora-1,SF1	Others	Others
	Sonoflora 1, also known as SF1, a PDT photosensitivizer. Chemically, SF1 is an analog of chlorophyll in that its macrocycle backbone is porphyrin-based and the center of the porphyrin ring consists of a metal ion. Preclinical studies showed that SF1 had v
T85211	Dieicosanoin Glycerol diarachidate	Others	Others
	Dieicosanoin是含有Arachidic acid的二酰基甘油，后者为一种20个碳主链的饱和长链脂肪酸，可从花生酱及厌氧真菌中提取。
T34180	Psilostachyin C NSC 106392	Others	Others
	Psilostachyin c is a member of the class of compounds known as ambrosanolides and secoambrosanolides. Ambrosanolides and secoambrosanolides are sesquiterpene lactones from the Ambrosia family, with a backbone derivative of azuleno[6,5-b]furan-2-one (ambro
T14448	Azido-PEG4-CH2-Boc	Others; ADC Linker	Antibody-drug Conjugate/ADC Related; Others
	Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl/ether moieties.
T76098	Glycerol-3-phosphate oxidase	Others	Others
	Glycerol-3-phosphate oxidase，即磷酸甘油氧化酶，是甘油代谢的关键中间体。Glycerol-3-phosphate oxidase 能够从大肠杆菌中提取得到。Glycerol-3-phosphate oxidase 是膜脂质的磷脂的骨架，也是呼吸链的底物。Glycerol-3-phosphate oxidase 通过氧化产生电子。
T37123	1,2-Dioctanoyl PC	Others	Others
	Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Dioctanoyl PC is a synthetic analog of natural phosphatidylcholine species containing saturated C8:O fatty acids in the sn-1 and sn-2 positions of the glycerol backbone. It exhibits a critical micelle concentration (CMC) value of 0.25 mM at 27°C. 1,2-Dioctanoyl PC serves as an efficient substrate for phospholipase D (PLD) as well as sPLA2 isozymes from bovine pancreas and bee venom...
T85008	Phosphatidylinositol (plant, wheat germ) sodium	Others	Others
	Phosphatidylinositols, comprising about 10% of total cellular phospholipids, are glycerophospholipids featuring a glycerol backbone, two non-polar fatty acid tails (primarily C16:0 and C18:0), and a polar inositol head group. Synthesized from cytidine diphosphate diacylglycerol (CPD-DAG) and myoinositol via phosphoinositol synthase, these compounds play pivotal roles in cellular processes, including calcium regulation, vesicle trafficking, mitogenesis, cell survival, and actin rearrangement. Pho...
T73753	Neuraminic acid	Others	Others
	Neuraminic acid是由9个碳原子的主链构成的酸性氨基糖，也是丙酮酸与D-甘露胺(2-氨基-2-脱氧甘露糖)醛酸经缩合反应生成的产物。它作为具有生物活性的黏液蛋白的官能团。
T38180	C16 Phytoceramide (t18:0/16:0)	Others	Others
	C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous ...
T37244	Palmitoyl thio-PC	Others	Others
	Thioester analogs of glycerophospholipids, in combination with Ellman's reagent, are convenient colorimetric substrates for the measurement of phospholipase (PL) activity. Palmitoyl thio-PC is a chromogenic PLA2 substrate that contains a palmitoyl thioester at the sn-2 position of the glycerol backbone. Hydrolysis of the thioester by PLA2 yields a free thiol that reacts readily with DTNB (Ellman's reagent) giving a bright yellow product with an absorbance maximum at 412 nm. Palmitoyl thio-PC has...
T85269	Sphingomyelin (chicken egg) SMs (egg)	Others	Others
	Sphingomyelins (SMs) are bioactive sphingolipids present in the cell membranes of mammals, constituting 2-15% of the total cellular phospholipid content, with higher concentrations in the brain and myelin sheaths of peripheral nerves. These compounds play a crucial role in modulating cholesterol distribution and maintaining cellular cholesterol balance. SMs are hydrolyzed by sphingomyelinase into ceramides, key sphingolipid signaling molecules. The product contains SM species predominantly with ...
T38291	C24 Phytosphingosine (t18:0/24:0)	Others	Others
	C24 Phytosphingosine (t18:0/24:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C24 Phytosphingosine (t18:0/24:0) is composed of a phytosphingosine backbone amine-linked to a C24 fatty acid chain. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous penetration and psoriasis in vitro. In a stratum corneum model of healthy skin, the inco...
T38280	C22 dihydro 1-Deoxyceramide (m18:0/22:0) C22 dihydro 1-Deoxyceramide (m18:0/22:0)	Others	Others
	C22 dihydro 1-Deoxyceramide (m18:0/22:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C22 dihydro 1-Deoxyceramide (m18:0/22:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found as the most prevalent dihydro...
T37458	C18 Phytoceramide (t18:0/18:0)	Others	Others
	C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis. Cer(t18:0/18:0) is composed of a phytosphingosine backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain. It also inhibits expression of the allergic cytokines IL-4, TN...
T38284	C24 dihydro 1-Deoxyceramide (m18:0/24:0) C24 dihydro 1-Deoxyceramide (m18:0/24:0)	Others	Others
	C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 dihydro 1-Deoxyceramide (m18:0/24:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found in mouse brain, spinal cord, ...
T84482	Oleoyl 3-carbacyclic Phosphatidic Acid 3-ccPA 18:1	Others	Others
	Cyclic Phosphatidic Acids (cPAs) are naturally occurring lysophosphatidic acid (LPA) analogs, characterized by a 5-membered ring formed between the sn-2 hydroxy group and the sn-3 phosphate. Carba-derivatives of cPA (ccPA) modify the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, hindering the conversion of cPA into LPA. Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) incorporates the 18:1 fatty acid oleate at the sn-1 position on the glycerol backbone, acting as a cyclic LPA analog. This compound...

化合物

4,4'-Iminodiphenol

Cat.No: T13507

Synonym: 4-(4-羟基苯胺)苯酚,Leucoindophenol

Target: Estrogen/progestogen Receptor

JAK1/2/3 Inhibitor 1

Cat.No: T77504

Target: PKA

Cat.No: T38896

Mal-PEG4-PFP ester

Cat.No: T15993

Target: Others, ADC Linker

Cat.No: T76708

Cat.No: T18488

Target: Others, ADC Linker

Propargyl-PEG1-SS-PEG1-PFP ester

Cat.No: T16591

Target: Others, ADC Linker

Cat.No: T34686

Synonym: SF 1,SF-1,Sonoflora1,Sonoflora-1,SF1

Target: Others

Cat.No: T85211

Synonym: Glycerol diarachidate

Target: Others

Psilostachyin C

Cat.No: T34180

Synonym: NSC 106392

Target: Others

Azido-PEG4-CH2-Boc

Cat.No: T14448

Target: Others, ADC Linker

Glycerol-3-phosphate oxidase

Cat.No: T76098

Target: Others

1,2-Dioctanoyl PC

Cat.No: T37123

Target: Others

Phosphatidylinositol (plant, wheat germ) sodium

Cat.No: T85008

Target: Others

Neuraminic acid

Cat.No: T73753

Target: Others

C16 Phytoceramide (t18:0/16:0)

Cat.No: T38180

Target: Others

Palmitoyl thio-PC

Cat.No: T37244

Target: Others

Sphingomyelin (chicken egg)

Cat.No: T85269

Synonym: SMs (egg)

Target: Others

C24 Phytosphingosine (t18:0/24:0)

Cat.No: T38291

Target: Others

C22 dihydro 1-Deoxyceramide (m18:0/22:0)

Cat.No: T38280

Synonym: C22 dihydro 1-Deoxyceramide (m18:0/22:0)

Target: Others

C18 Phytoceramide (t18:0/18:0)

Cat.No: T37458

Target: Others

C24 dihydro 1-Deoxyceramide (m18:0/24:0)

Cat.No: T38284

Synonym: C24 dihydro 1-Deoxyceramide (m18:0/24:0)

Target: Others

Oleoyl 3-carbacyclic Phosphatidic Acid

Cat.No: T84482

Synonym: 3-ccPA 18:1

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T17155	Trabectedin Ecteinascidin 743,曲贝替定,ET-743	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱，有抗肿瘤的活性，通过与 DNA 的小沟结合，阻断应激诱导的蛋白质的转录，诱导 DNA 骨架裂解和癌细胞凋亡，并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。
T8240	Cis-5-Dodecenoic Acid	Others	Others
	Cis-5-Dodecenoic Acid 是一种单不饱和脂肪酸，具有 C12 链作为主链，C5 位具有顺式双键。
T5658	Adamantane	Others	Others
	Adamantane 是许多化合物的结构骨架，也是有机多面体化合物的物理化学和生物学特性，在制药工业中有实际应用。
T6873	Lauric Acid 月桂酸,Dodecylic acid,dodecanoic acid,Vulvic acid,N-Dodecanoic acid	Others; Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology; Others
	Lauric Acid (Dodecylic acid) 是一种有抗菌活性的中链脂肪酸，对P. acnes，S.aureus 和S. epidermidis 的 EC50值分别为 2，6，4 μg/mL。
T2910	Flavonol 3-羟基黄酮,3-Hydroxyflavone,3-HF,Flavon-3-ol,3-Hydroxy-2-phenylchromone	Others; Endogenous Metabolite	Metabolism; Others
	Flavonol (3-Hydroxyflavone) 是内源性代谢产物的一种。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T40589	6-O-β-D-Galactopyranosyl-D-galactose	Others	Others
	6-O-beta-D-Galactopyranosyl-D-galactose, a disaccharide, is a constituent of the polysaccharide backbone characterized by beta-(1→6) glycoside linkages, with a side chain attached to the primary chain through a beta-(1→3) bond.
T13729	Hydrolyzed Fumonisin B1 Aminopentol	Others	Others
	Hydrolyzed Fumonisin B1 is the backbone and the main hydrolysis product of the mycotoxin fumonisin B1 (FB1), can weakly inhibit ceramide synthase.
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,

天然产物

Cat.No: T17155

Synonym: Ecteinascidin 743,曲贝替定,ET-743

Target: Apoptosis, Reactive Oxygen Species

Cis-5-Dodecenoic Acid

Cat.No: T8240

Target: Others

Cat.No: T5658

Target: Others

Cat.No: T6873

Synonym: 月桂酸,Dodecylic acid,dodecanoic acid,Vulvic acid,N-Dodecanoic acid

Target: Others, Endogenous Metabolite, Antibacterial

Cat.No: T2910

Synonym: 3-羟基黄酮,3-Hydroxyflavone,3-HF,Flavon-3-ol,3-Hydroxy-2-phenylchromone

Target: Others, Endogenous Metabolite

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

6-O-β-D-Galactopyranosyl-D-galactose

Cat.No: T40589

Target: Others

Hydrolyzed Fumonisin B1

Cat.No: T13729

Synonym: Aminopentol

Target: Others

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00767	Gellan lyase Protein, Geobacillus stearothermophilus, Recombinant (His) Gellan lyase	Geobacillus stearothermophilus	E. coli
	Cleaves the glycosidic bonds of gellan backbone and releases tetrasaccharide units of glucuronyl-glucosyl-rhamnosyl-glucose with unsaturated glucuronic acid at the non-reducing terminal. The enzyme is highly specific to the heteropolysaccharide gellan. Gellan lyase Protein, Geobacillus stearothermophilus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 24.5 kDa and the accession number is P85513.
TMPY-02798	NEIL1 Protein, Human, Recombinant (His) NEI1,nei endonuclease VIII-like 1 (E. coli),FPG1,hFPG1	Human	E. coli
	NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed and replaced. The first step of this process is catalyzed by DNA glycosylases. They remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. NEIL1 functions in base excision r...
TMPH-03385	Thyroglobulin Protein, Rat, Recombinant (His & SUMO) Tg,Thyroglobulin	Rat	E. coli
	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. Thyroglobulin Protein, Rat, Recombin...
TMPH-01008	PNKP Protein, Human, Recombinant (His & SUMO) Polynucleotide kinase-3'-phosphatase,PNKP,DNA 5'-kinase/3'-p...	Human	E. coli
	Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone. PNKP Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The ...
TMPH-02162	Synaptotagmin-1 Protein, Human, Recombinant (His) SYT1,Synaptotagmin-1,p65,Synaptotagmin I	Human	E. coli
	Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at leas...
TMPH-01241	TOP1 Protein, Human, Recombinant (His & Myc) DNA topoisomerase 1,TOP1,DNA topoisomerase I	Human	Baculovirus Insect Cells
	Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates a...
TMPY-02522	OTUB2 Protein, Human, Recombinant (His) OTU deubiquitinase, ubiquitin aldehyde binding 2,OTU2,OTB2,C...	Human	E. coli
	Otubain 2 (OTUB2) is a member of DUBs that belong to the ovarian tumour (OTU) superfamily of proteins which consists of a five-stranded β-sheet sandwiched in between a small helical amino-terminal region consisting of α1 and α2, and a large helical region comprised of α3-α10. Like other DUBs, otubain 2 (OTUB2) cleaves proteins precisely at the ubiquitin-protein bond so that ubiquitylation process can be reversed and regulated. Otubain 2 (OTUB2)'s active-site cleft is sterically occluded by a nov...

重组蛋白

Gellan lyase Protein, Geobacillus stearothermophilus, Recombinant (His)

Cat.No: TMPH-00767

Species: Geobacillus stearothermophilus

Expression System: E. coli

NEIL1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02798

Species: Human

Expression System: E. coli

Thyroglobulin Protein, Rat, Recombinant (His & SUMO)

Cat.No: TMPH-03385

Species: Rat

Expression System: E. coli

PNKP Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01008

Species: Human

Expression System: E. coli

Synaptotagmin-1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02162

Species: Human

Expression System: E. coli

TOP1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01241

Species: Human

Expression System: Baculovirus Insect Cells

OTUB2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02522

Species: Human

Expression System: E. coli

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