amylin , human

Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type II diabetes mellitus.

Acetyl-Amylin (8-37) (human) 是特异性的 amylin 拮抗剂。

Amylin, amide, human TFA 是一种含有37个氨基酸的胰腺多肽，与胰岛素共同分泌，对代谢和维持葡萄糖稳态具有重要作用。该化合物能够抑制胰高血糖素的分泌，延缓胃排空速度，同时作为增加饱腹感的因子。

Amylin (8-37) (human) (hIAPP (8-37))，为人类胰岛淀粉样多肽(IAPP)第8至第37位氨基酸片段。该片段在组装过程中形成带有发夹结构的双重折叠构型。

Amylin (8-37), human acetate(135702-23-7 free base) 源自人 Amylin，对大鼠离体肠系膜阻力动脉具有直接血管舒张作用。 Amylin (8-37), human acetate，是一种小型胰腺 β 细胞激素，在没有胰岛素的情况下会形成聚集体，是 II 型糖尿病的一个关键病理特征。

Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitu

Amylin (1-37) (human) (hIAPP (1-37)) 为胰岛β细胞分泌颗粒中的肽类激素，其C端经酰胺化处理，第2和第7个半胱氨酸残基间形成二硫键。

NF(N-Me)GA(N-Me)IL是一种改性的生物活性肽，对应于人胰岛淀粉样蛋白多肽hIAPP中的22至27氨基酸片段（NFGAIL），其G24和I26的酰胺键经N-甲基化处理。引入N-甲基基团使得原本促进淀粉样蛋白形成及具细胞毒性的序列变为不促进淀粉样蛋白形成和无细胞毒性。此肽可高亲和力结合至全长hIAPP，并有效抑制其纤维化过程。

Pramlintide acetate是人源淀粉样肽的多肽类似物。作为一种抗糖尿病药物，它在结直肠癌中展现出抗肿瘤活性。

Pramlintide TFA，一种人类淀粉样肽类似物，主要作为抗糖尿病药物使用，并可用于肠癌研究。

Tyr-α-CGRP is an N-terminal extended tyrosinated analogue of α-calcitonin gene-related peptide . It binds to amylin receptors AMY1 and AMY3 in COS-7 cells expressing the human receptors (IC50s = 141 and 1.86 nM, respectively). Tyr-α-CGRP also binds to and stimulates cAMP accumulation in rat L6 myocytes (IC50 = 4 nM; EC50 = 12 nM). It also binds to rat brain and spleen membrane preparations (IC50s = 0.2 and 0.5 nM, respectively), induces positive chronotropic and inotropic effects in isolated right and left guinea pig atria (EC50s = 282 and 74 nM, respectively), and inhibits the twitch response in rat vas deferens (EC50 = 1.9 nM).

Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.