amylin, amide, rat

Amylin is a peptide that displays 50% homology with calcitonin gene-related peptide (CGRP), Amylin is colocalized with somatostatin in endocrine cells of the gastric fundus. In isolated mouse stomach, amylin caused a concentration-dependent decrease in ac

Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL2) receptor (EC50= 9.32 nM in a fluorescence imaging plate reader assay).1It selectively binds to the GAL2receptor (IC50= 1.76 nM for the rat receptor) over the GAL1receptor (IC50= 879 nM for the human receptor) but does also bind to the GAL3receptor (Ki= 271 nM for the rat receptor).1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.3It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.1

(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) 是一种有效的 PTH-1R 拮抗剂。

GLP-1(1-36) amide (human, rat)（人类及大鼠的胰高血糖素样肽1（1-36）酰胺）是GLP-1(7-36)酰胺的一种分子变体。该化合物能激发[14C]氨基吡啶在大鼠胃壁细胞的酶分散体中积累。

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) 是一段具有抑制骨吸收作用的C端甲状旁腺激素相关蛋白片段。

pTH-Related Protein (7-34) amide (human, mouse, rat) 为一种高效的甲状旁腺激素 (PTH) 拮抗剂。

GLP-1(1-36) amide (human, rat) TFA为胰高血糖素样肽1(GLP-1)-(7-36)酰胺的分子变体，能够促进[14C]氨基吡啶在大鼠壁细胞的酶分散体中的积累。

Amylin (8-37), rat, is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Also known as islet amyloid precursor peptide (IAPP), Amylin is co-secreted with insulin.

pTH-Related Protein (1-34) amide (human, mouse, rat) 为PTHrP的N末端片段，能够诱导高钙血症，适于研究与恶性肿瘤相关的体液性高钙血症。

GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and truncated GLP-1 (7-36) amide , in pancreatic tissue compared to wild-type mice.2References1. Schjoldager, B.T., Mortensen, P.E., Christiansen, J., et al. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans. Dig. Dis. Sci. 34(5), 703-708 (1989).2. Gelling, R.W., Du, X.Q., Dichmann, D.S., et al. Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100(3), 1438-1443 (2003). GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and truncated GLP-1 (7-36) amide , in pancreatic tissue compared to wild-type mice.2 References1. Schjoldager, B.T., Mortensen, P.E., Christiansen, J., et al. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans. Dig. Dis. Sci. 34(5), 703-708 (1989).2. Gelling, R.W., Du, X.Q., Dichmann, D.S., et al. Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice. Proc. Natl. Acad. Sci. U.S.A. 100(3), 1438-1443 (2003).

Amylin, amide, human TFA 是一种含有37个氨基酸的胰腺多肽，与胰岛素共同分泌，对代谢和维持葡萄糖稳态具有重要作用。该化合物能够抑制胰高血糖素的分泌，延缓胃排空速度，同时作为增加饱腹感的因子。

Caveolin-1 (82-101) amide (human, mouse, rat) (Caveolin-1 scaffolding domain peptide) 是抑制酪氨酸激酶的肽，可逆转多器官衰老相关的有害变化。

Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitu