Aminooxy-PEG2-alcohol is a non-cleavable PEG linker consisting of two units, utilized in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound serves as a PEG-based PROTAC linker for the synthesis of PROTACs as well [2].
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].
m-PEG-Aminooxy (MW 2000) is a polyethylene glycol (PEG) derived PROTAC linker, primarily utilized for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized conjugate compound known as an E3 ligase ligand-linker. It incorporates a cereblon ligand based on Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology applications.
Azide-PEG-alcohol, a polyethylene glycol (PEG)-based PROTAC linker with a molecular weight of 2000, functions as a versatile option for the synthesis of PROTACs[1].
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly utilized in PROTAC technology. This compound acts as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.
DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker. This specific linker is utilized in the synthesis of PROTACs, or proteolysis targeting chimeras [1].
t-Boc-Aminooxy-PEG3-alcohol is a polyethylene glycol (PEG)-based linker compound commonly employed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].