Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11-unit polyethylene glycol (PEG) linker that finds application in the synthesis of antibody-drug conjugates (ADCs) [1].
Fmoc-N-amido-PEG2-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Propargyl-PEG5-1-o-b-cyanoethyl-nn-diisopropylphosphoramidite is a polyethylene glycol (PEG)-based linker molecule specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs).
Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable. Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516
Pomalidomide-amino-PEG5-NH2 hydrochloride is a chemical compound that has been synthesized as an E3 ligase ligand-linker conjugate. This compound combines a Pomalidomide-based cereblon ligand with a linker commonly used in PROTAC technology.
N-Mal-N-bis(PEG2-NH-Boc) is a polyethylene glycol (PEG) derived linker specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].
N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a polyethylene glycol (PEG)-derived linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
m-PEG-triethoxysilane (MW 1000) is a polyethylene glycol (PEG) derivative functionalized with triethoxysilane. It acts as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs), a class of compounds used for targeted protein degradation[1].
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].
Amino-PEG5-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
N-Boc-PEG5-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
N-Mal-N-bis(PEG2-amine) is a polyethylene glycol (PEG)-based linker compound commonly employed in the construction of PROTACs, or proteolysis-targeting chimeras[1].
Azide-PEG-amine (MW 3500) is a polyethylene glycol (PEG) derived linker compound, specifically designed for the synthesis of proteolysis targeting chimeric molecules (PROTACs)[1].
Bis-PEG5-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 ligand Bestatin, leading to the creation of SNIPER[1].
Thiol-PEG-CH2COOH (MW 5000) is a Polyethylene glycol (PEG) derived link molecule, commonly utilized in the construction of PROTACs, which are bifunctional compounds designed for targeted protein degradation [1].
N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker that incorporates biotin for labeling purposes. This compound serves as a versatile tool in the synthesis of PROTACs[1].
N-(Amino-PEG3)-N-bis(PEG3-acid) is a polyethylene glycol (PEG)-based linker compound utilized for synthesizing proteolysis-targeting chimeras (PROTACs)[1].
Mal-PEG-mal (MW 3400) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
m-PEG6-amino-Mal is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
m-PEG-triethoxysilane (MW 2000) is a polyethylene glycol (PEG) based linker compound, specifically designed for the purpose of synthesizing proteolysis-targeting chimeras (PROTACs)[1].
NH-bis-PEG5 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Mal-N-bis(PEG4-C2-acid) is a polyethylene glycol (PEG) derivative serving as a PEG-based PROTAC linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
N-Me-N-bis-PEG3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Amino-PEG5-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Bis-Tos-PEG6 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Mal-amido-PEG10-C2-NHS ester is a noncleavable ADC linker, comprising a maleimide group and an NHS ester, which serves as a labeling agent for primary amines (-NH2) found in proteins, amine-modified oligonucleotides, and other amine-containing molecules[1][2].
m-PEG-acrylate (MW 2000) is a polyethylene glycol (PEG) derivative linker, which serves as a crucial component in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
Azide-PEG-azide (MW 20000) is a polyethylene glycol (PEG)-based linker compound utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
N-(NHS-PEG3)-N-bis(PEG3-azide) is a polyethylene glycol (PEG)-based linker commonly utilized for the synthesis of proteolysis targeting chimeras (PROTACs)[1].