DBCO-C2-SulfoNHS ester is an alkyl ether-based linker commonly employed for the synthesis of PROTACs, a class of compounds that induce targeted protein degradation.
Propargyl-PEG3-PFPester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
The N3-PEG2-C2-PFPester, a nonclaevable 2-unit polyethylene glycol (PEG) linker, is commonly employed in the synthesis of antibody-drug conjugates (ADCs).
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a chemically synthesized compound, designed as an E3 ligase ligand-linker conjugate, integrating the cereblon ligand derived from Pomalidomide and a linker employed in PROTAC technology. This compound serves to facilitate targeted protein degradation through the modulation of E3 ligase activity, enabling the selective elimination of specific proteins of interest.
DBCO-C-PEG1 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Azido-PEG6-PFPester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].
Propargyl-PEG1-SS-PEG1-PFPester is a cleavable linker consisting of a 1-unit polyethylene glycol (PEG) backbone, designed for use in the synthesis of antibody-drug conjugates (ADCs)[1].
Boc-Aminooxy-PEG1-C2-NH2 is a polyethylene glycol (PEG)-derived linker compound, specifically designed for incorporation into proteolysis targeting chimeras (PROTACs)[1].
Biotin-PEG36-PFPester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Bis-PEG3-PFPester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
NHPI-PEG3-C2-Pfpester is a trifunctional polyethylene glycol (PEG) linker molecule, employed specifically in the fabrication of antibody-drug conjugates (ADCs).
NHPI-PEG3-C2-NHS ester is a three-unit PEG linker compound, noncleavable in nature, specifically employed in the synthesis of antibody-drug conjugates (ADCs).
Bis-PEG5-PFPester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Acid-C2-PEG3-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Azido-PEG1-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Propargyl-NH-PEG3-C2-NHS ester is a non-cleavable triethylene glycol linker with propargyl and N-hydroxysuccinimide functional groups. It is utilized in the synthesis of antibody-drug conjugates (ADCs)[1].
Ald-Ph-PEG2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride is a chemical compound that features a cereblon (CRBN) ligand, functioning as an E3 ubiquitin ligase, along with a linker. It can be utilized to create the PROTAC MD-224[1].
Tri-(PEG1-C2-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
BCN-PEG3-VC-PFPester is a three-unit PEG ADC linker that can be cleaved, and it is commonly employed in the synthesis of antibody-drug conjugates (ADCs) [1].
Mal-PEG6-PFPester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.