ahpc-peg2-nh2 dihydrochloride

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) 包含基于 (S,R,S)-AHPC 的 VHL 配体和 2 个单元 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物，可用于 PROTAC 分子的合成。

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, which binds to MCL1 with a KD of 30 nM. dmcl-2 activates the apoptosis mechanism by degrading MCL1.This compound is unstable in powder form and other related salt forms are recommended.

5-Ethynyl-2'-deoxyuridine 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 的合成分子。它是一种胸腺嘧啶核苷类似物，在细胞增殖时能够插入正在复制的 DNA 分子中， EdU 与染料的共轭反应可以进行高效快速的细胞增殖检测分析。

1,2-Bis(2-iodoethoxy)ethane 是一种属于 PEG 类的 PROTAC linker，可用于 MT802 和 SJF620 的合成。其中 MT-802 和 SJF620 都是 PROTAC BTK 降解剂，DC50分别为 1 和 7.9 nM。

2-Phthalimidehydroxy-acetic acid 是一种属于 alkyl chain 类的 PROTAC linker，可用于 PROTAC 分子的合成。

Hydroxy-PEG4-(CH2)2-Boc 是一种不可切割的 ADC 接头，用于合成抗体-药物偶联物。它也可用作 PROTAC 接头用于 PROTAC 合成。.

PROTAC ERRα ligand 2 是雌激素相关受体 α （ERRα）反向激动剂。它对 ERRα (IC50=5.67 nM) 的抑制作用比 XCT790 (IC50=61.3 nM) 高效约 11 倍。

TSPO ligand-2 (Carbonic acid) 是 AUTAC1 的配体，AUTAC1含有一个对氟苄基鸟嘌呤和一个烟曲霉醇部分。

PROTACKRAS G12C degrader-2 (compound 432) 作为一种双功能化合物，主要功能是调节K-Ras蛋白的水解。该化合物一端配备了小脑细胞凋亡蛋白抑制剂 (IAP)，而另一端则含有能够与KRAS结合的片段。

Bcl-2 Bcl-xI ligands 1 作为一种Bcl-2 Bcl-xI配体，主要用于合成PROTAC Bcl-2 Bcl-xI Degrader-1。

CBP p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300 CBP.

Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 - linker 9 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a polyethylene glycol (PEG)-based linker for PROTAC synthesis [1].

(2-Pyridyldithio)-PEG4-propargyl is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Boc-NH-PEG-amine (MW 3400) serves as a PEG-based PROTAC linker and finds application in PROTAC synthesis[1].

2-Amino-1,3-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based linker utilized for PROTAC synthesis[1].

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate, an ADC linker, is a glutathione cleavable compound used for the attachment of monoclonal antibodies (mAb) in antibody-drug conjugates (ADCs). It specifically refers to the Alkyl-Chain composition of the linker portion of these molecules [1].

(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is an E3 ligase ligand-linker conjugate, specifically designed for targeting the EED protein in PROTAC applications[1].

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-derived PROTAC linker applicable for synthesizing PROTACs[1].

PROTAC EED degrader-2 is a PROTAC targeting EED (pKD of 9.27) and an inhibitor of polycomb repressive complex 2 (PRC2) with a pIC50 of 8.11.

(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flexibility and biocompatibility for optimal drug release while maintaining stability throughout the circulation in the body. Ultimately, (2-Pyridyldithio)-PEG4 acid is instrumental in the development and advancement of ADCs, a promising approach in cancer therapy.

cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER.

(2-Pyridyldithio)-PEG2-Boc is a polyethylene glycol-based PROTAC linker utilized for the synthesis of PROTACs[1].

Boc-NH-PEG-amine (MW 5000) is a PEG-based PROTAC linker enabling the synthesis of PROTACs [1].

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a polyethylene glycol (PEG) derivative that serves as a linker for proteolysis targeting chimeras (PROTACs) synthesis [1].

(S,R,S)-AHPC-C4-NH2 dihydrochloride is a chemically derived E3 ligase ligand-linker conjugate, consisting of the (S,R,S)-AHPC VHL ligand and a linker specifically designed for EED-Targeted PROTAC[1].

ML 2-23是一种有效的PROTAC BCR-ABL降解剂，可在白血病细胞中通过蛋白酶体依赖的途径选择性地降解BCR-ABL。

PROTACBcI-2 BcI-xI Degrader-1 (15) 是一种用于降解BcI-2 BcI-xI的PROTAC降解剂 (Red: BcI-2 BcI-xI inhibitor, black: linker, Blue: E3 ligase ligand)。

Thalidomide-NH-CBP p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).

PROTACTTK degrader-2是一种TTK(苏氨酸酪氨酸激酶)的高效PROTAC降解剂，其在COLO-205和HCT-116细胞中分别展现出3.1和12.4 nM的DC50值。在COLO-205人结直肠癌细胞异种移植小鼠模型中，此化合物证实了其针对性降解与抗癌活性。

(S,R,S)-AHPC-C2-NH2 dihydrochloride is a combination of a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. It enables the synthesis of various PROTACs.

PROTACBTK Degrader-2 是一种有效的BTKPROTAC 降解剂。PROTACBTK Degrader-2 可有效降低BTK 蛋白水平。

DNA crosslinker 2 (dihydrochloride)为一种高效DNA小沟结合剂，其结合亲和力(ΔTm)达1.2°C。该化合物对NCI-H460、A2780及MCF-7癌细胞展示出抑制活性，适用于抗癌研究。

Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was VH 032 phenol - linker 1 PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate compound that combines a Thalidomide-based cereblon ligand and a linker, which is commonly utilized in PROTAC technology. This compound acts as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

2-Hydroxyethyl disulfide mono-tosylate is a cleavable linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1].

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker. This specific linker is utilized in the synthesis of PROTACs, or proteolysis targeting chimeras [1].

MAC glucuronide linker-2 is an ADC linker employed in the synthesis of ADCs, offering cleavability [1].

Propargyl-PEG13-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drug conjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrates potent efficacy against c-Kit expressing cell lines, including GIST-T1 and NCI-H526, with IC50 values of <7 pM and 40 pM, respectively.

K-Ras ligand-Linker Conjugate 2 is a chemical compound that includes a ligand for K-Ras and a PROTAC linker. This compound is capable of recruiting E3 ligases like VHL, CRBN, MDM2, and IAP. It is utilized in the synthesis of PROTAC K-Ras Degrader-1, which is a highly effective PROTAC K-Ras degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker utilized in the synthesis of PROTACs[1].

cIAP1 Ligand-Linker Conjugates 2 Hydrochloride is a chemical compound that combines an IAP ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is utilized in the creation of SNIPERs[1].

DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2. MMAE, a potent tubulin inhibitor, serves as the cytotoxic component in this formulation.

m-PEG6-2-methylacrylate is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

2-Bromo-22-dimethyl-acetamido-PEG3-acid is a polyethylene glycol (PEG) derivative commonly employed as a PEG-based PROTAC linker during PROTAC synthesis[1].

PROTACBRD3 BRD4-L degrader-2 是一款可以特异性地降解BRD3和BRD4-L的PROTAC分子，其对BRD3的Ki值为16.91 nM，对BRD4-L为2.8 nM。在小鼠异种移植模型中，该分子展示了卓越的抗肿瘤效果，可被应用于癌症相关研究。

CDK7 ligand 2 (Compound A6) 作为一种CDK7配体，主要用于PROTACs的合成。