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Search Results for " adenoma "

Targets Recommended: COX Carbonic Anhydrase

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T21294	Polmacoxib CG-100649,帕马考昔,CG100649,CG 100649	COX; Carbonic Anhydrase	Immunology/Inflammation; Metabolism; Neuroscience
	Polmacoxib (CG 100649) 是一流的 NSAID 候选药物，是碳酸酐酶 (CA) 和 COX-2 的双重抑制剂。它在小鼠模型中抑制大肠腺瘤和肿瘤生长。
T8359	Lanreotide acetate Lanreotide acetate (108736-35-2 free base),BIM 23014 (acetate),BIM 23014 acetate	Others	Others
	Lanreotide acetate (BIM 23014 acetate) 是生长抑素类似物，具有抗肿瘤活性，可用于类癌综合症。
T41179	CL 82198 hydrochloride	Others	Others
	CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibitsin vitroinvasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.
T74815	SLC26A3-IN-2	Others	Others
	SLC26A3-IN-2 是一种口服有效的阴离子交换蛋白 SLC26A3的抑制剂 (IC50=360 nM)。SLC26A3 属于溶质载体 (SLC) 蛋白，属于 SLC26 家族。SLC26 家族对氯化物、碳酸氢盐、硫酸盐和草酸盐具有广泛的阴离子特异性。SLC26A3 在腺瘤 (DRA) 中下调，参与氯化物和草酸盐的肠道吸收。SLC26A3 功能突变的丧失与氯离子丢失性腹泻有关。

化合物

Polmacoxib

Cat.No: T21294

Synonym: CG-100649,帕马考昔,CG100649,CG 100649

Target: COX, Carbonic Anhydrase

Lanreotide acetate

Cat.No: T8359

Synonym: Lanreotide acetate (108736-35-2 free base),BIM 23014 (acetate),BIM 23014 acetate

Target: Others

CL 82198 hydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
TQ0193	N2,N2-Dimethylguanosine N2,N2-二甲基鸟苷	Endogenous Metabolite	Metabolism
	N2,N2-Dimethylguanosine 是尿核苷，是 tRNA 的初级代谢产物。
T36472	Tetrahydro-11-deoxy Cortisol	Others	Others
	Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

天然产物

N2,N2-Dimethylguanosine

Cat.No: TQ0193

Synonym: N2,N2-二甲基鸟苷

Target: Endogenous Metabolite

Tetrahydro-11-deoxy Cortisol

Cat.No: T36472

Synonym:

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01169	IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated Interleukin-23 subunit α,Interleukin-23 subunit alpha,IL-23 ...	Mouse	HEK293 Cells
	The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells. A recent study has reported that IL-23 is also secreted by lung adenoma cells and generates an inflammatory and immune-suppressed stroma.
TMPY-02319	Galectin-3 Protein, Human, Recombinant GALBP,CBP35,GAL3,GALIG,MAC2,LGALS2,lectin, galactoside-bindi...	Human	E. coli
	LGALS3 (Galectin 3) is a Protein Coding gene. This gene encodes a member of the galectin family of carbohydrate-binding proteins. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. LGALS3 is a beta-galactoside-binding lectin and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion, and T-cell regulation. LGALS3 has an important role in tumor progression through...
TMPY-03329	DPEP1 Protein, Human, Recombinant (His) MBD1,dipeptidase 1,MDP,RDP	Human	HEK293 Cells
	Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correlated with parameters of pathological aggressiveness and poor prognosis. The overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatment decreased DPEP1 expression. Dehydropeptidase-I m...