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Search Results for " actin-related "

Targets Recommended: Others

9

抑制剂 & 化合物

1

天然产物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2164	Wiskostatin	Others	Others
	Wiskostatin 是神经元 Wiskott-Aldrich 综合征蛋白介导的肌动蛋白聚合的选择性抑制剂，能够不可逆的使细胞 ATP 水平快速下降。
T5860	CK-869	Microtubule Associated	Cytoskeletal Signaling
	CK-869 是一种肌动蛋白相关蛋白 2/3 复合体抑制剂，其 IC50值为 7 μM。
T5007	Benproperine phosphate 磷酸苯丙哌林,Blascorid,Pirexyl phosphate	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	Benproperine phosphate (Pirexyl phosphate) 是一种具有口服活性的，肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。它通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。它可抑制癌细胞迁移和肿瘤转移，有用于治疗止咳的潜力。
T10826	CK-666	HIV Protease; Microtubule Associated	Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome
	CK-666 是一种肌动蛋白相关蛋白 Arp2/3 复合物的细胞渗透性抑制剂。它与 Arp2/3 复合物结合，稳定复合物的非活性状态，阻止 Arp2 和 Arp3 亚基进入活化的丝状短节距构象。
T1820	CK-636 CK-0944636,CK 636	Microtubule Associated	Cytoskeletal Signaling
	CK-636 (CK-0944636)是一种具有细胞渗透性的Arp2/3复合体抑制剂，能抑制肌动蛋白的聚合，对人，裂殖酵母和牛的IC50值分别为4、24 和 32 μM。
T7764	CCG-222740	ROCK; Rho; Ras	Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells
	CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂，可减少皮肤纤维化并阻止黑色素瘤转移。
T10616	BRM/BRG1 ATP Inhibitor-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRM/BRG1 ATP Inhibitor-1 是变构双 Brahma 同源物 (BRM)/SWI/SNF 相关的基质相关肌动蛋白依赖性调节剂，染色质亚家族 A 成员 2 和 BRG1/SMARCA4 ATP 酶活性抑制剂，IC50值低于 0.005 μM。
T25529	IMM-01	GTPase	GPCR/G Protein
	IMM-01 是一类新型的哺乳动物透明 (mDia) 相关形式的小分子激动剂，其作用于 Rho GTPase 下游以组装肌动蛋白丝，并与微丝组织在迁移和不对称分裂过程中建立和维持细胞极性. GTP 结合的 Rho 通过破坏 DID 和 DAD 自动调节结构域之间的相互作用来激活 mDia 家族成员，从而释放 FH2 结构域以调节肌动蛋白和微管动力学。
T23892	CK548 CK 548,CK-548	Others	Others
	CK548 is a novel actin-related protein (Arp)2/3 complex inhibitor.

化合物

Cat.No: T2164

Target: Others

Cat.No: T5860

Target: Microtubule Associated

Benproperine phosphate

Cat.No: T5007

Synonym: 磷酸苯丙哌林,Blascorid,Pirexyl phosphate

Target: Others, Microtubule Associated

Cat.No: T10826

Target: HIV Protease, Microtubule Associated

Cat.No: T1820

Synonym: CK-0944636,CK 636

Target: Microtubule Associated

Cat.No: T7764

Target: ROCK, Rho, Ras

BRM/BRG1 ATP Inhibitor-1

Cat.No: T10616

Target: Epigenetic Reader Domain

Cat.No: T25529

Target: GTPase

Cat.No: T23892

Synonym: CK 548,CK-548

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3S1471	Cucurbitacin IIA 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis; Survivin	Apoptosis
	Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯，可诱导细胞凋亡和增强自噬，有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。

天然产物

Cucurbitacin IIA

Cat.No: T3S1471

Synonym: 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00358	Arp3/ACTR3 Protein, Human, Recombinant (His & GST) ARP3,ARP3 actin-related protein 3 homolog ...	Human	Baculovirus Insect Cells
	Arp3/ACTR3 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.1 kDa and the accession number is A0A024RAI1.
TMPH-02160	SMARCB1 Protein, Human, Recombinant (His) BRG1-associated factor 47,SNF5 homolog,Integrase interactor ...	Human	E. coli
	SMARCB1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 49.0 kDa and the accession number is Q12824.
TMPH-01905	SMARCA2 Protein, Human, Recombinant (His) Probable global transcription activator SNF2L2,SWI/SNF-r...	Human	P. pastoris (Yeast)
	SMARCA2 Protein, Human, Recombinant (His) is expressed in Yeast.
TMPH-02159	SMARCC1 Protein, Human, Recombinant (His & SUMO) SWI/SNF-related matrix-associated actin-de...	Human	E. coli
	SMARCC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.5 kDa and the accession number is Q92922.
TMPH-01906	SMARCA2 Protein, Human, Recombinant (His & SUMO) BRG1-associated factor 190B,SNF2-alpha,SWI/SNF-related	Human	E. coli
	SMARCA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-00841	SMARCA4 Protein, Human, Recombinant (His) ATP-dependent helicase SMARCA4,Mitotic growth and transcript...	Human	E. coli
	SMARCA4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.1 kDa and the accession number is P51532.
TMPH-02217	SMARCA4 Protein, Human, Recombinant (His) Transcription activator BRG1,Protein brahma homolog 1,SWI/SN...	Human	P. pastoris (Yeast)
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl...
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc) ATR,TEM8,anthrax toxin receptor 1,GAPO	Human	HEK293 Cells
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key pro...
TMPJ-00327	M-CSF/CSF1 Protein, Human, Recombinant (His) Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St...	Human	HEK293 Cells
	Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio...
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST) v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPY-02847	Moesin Protein, Human, Recombinant (aa 1-346, His) moesin,HEL70	Human	E. coli
	Moesin is a member of the ERM family which includes ezrin and radixin. ERM proteins, highly related members of the larger protein 4.1 superfamily, can exist in an active or inactive conformation. It seems that ERM proteins function as cross-linkers between plasma membranes and actin-based cytoskeletons. The sole Drosophila ERM protein, moesin, functions to promote cortical actin assembly and apical-basal polarity. As a result, cells lacking moesin lose epithelial characteristics and adopt invasi...
TMPY-01958	RhoA Protein, Human, Recombinant (His) ras homolog family member A,ARHA,RHO12,RHOH12,ARH12	Human	Baculovirus Insect Cells
	Transforming protein RhoA, also known as Rho cDNA clone 12, Ras homolog gene family member A, RHOA and ARH12, is a cell membrane and cytoplasm protein that belongs to the small GTPase superfamily and Rho family. The Rho family of small GTPases plays a key role in the dynamic regulation of the actin cytoskeleton that underlies various important cellular functions such as shape changes, migration, and polarity. RHOA / ARH12 is part of a larger family of related proteins known as the Ras superfamil...
TMPJ-00045	Podoplanin Protein, Human, Recombinant (hFc) T1A,PDPN,GP36,Podoplanin,Aggrus,T1-α,PA2.26 Antigen,T1-Alpha...	Human	HEK293 Cells
	Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cy...
TMPJ-01415	ANGPTL4 Protein, Mouse, Recombinant (hFc) Angptl4,HFARP,Fasting-induced adipose factor,Fiaf,Secreted p...	Mouse	HEK293 Cells
	Angiopoietin-related protein 4（ANGPTL4）is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity...
TMPY-02439	Rac2 Protein, Human, Recombinant (His) p21-Rac2,HSPC022,Gx,EN-7,ras-related C3 botulinum t...	Human	E. coli
	Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is attached to the small G-protein, the enzyme is inactivated. Release of the GDP and replace of the GTP cativate the GTPasee. Rac2 remains active until the GTP is hydrolyzed to GDP. Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADP...
TMPY-02106	GAP43 Protein, Human, Recombinant (His) B-50,PP46,growth associated protein 43	Human	HEK293 Cells
	Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of n...

重组蛋白

Arp3/ACTR3 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-00358

Species: Human

Expression System: Baculovirus Insect Cells

SMARCB1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02160

Species: Human

Expression System: E. coli

SMARCA2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01905

Species: Human

Expression System: P. pastoris (Yeast)

SMARCC1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02159

Species: Human

Expression System: E. coli

SMARCA2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01906

Species: Human

Expression System: E. coli

SMARCA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-00841

Species: Human

Expression System: E. coli

SMARCA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-02217

Species: Human

Expression System: P. pastoris (Yeast)

TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02953

Species: Human

Expression System: HEK293 Cells

M-CSF/CSF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00327

Species: Human

Expression System: HEK293 Cells

C-ABL/ABL1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04396

Species: Human

Expression System: Baculovirus Insect Cells

Moesin Protein, Human, Recombinant (aa 1-346, His)

Cat.No: TMPY-02847

Species: Human

Expression System: E. coli

RhoA Protein, Human, Recombinant (His)

Cat.No: TMPY-01958

Species: Human

Expression System: Baculovirus Insect Cells

Podoplanin Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00045

Species: Human

Expression System: HEK293 Cells

ANGPTL4 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01415

Species: Mouse

Expression System: HEK293 Cells

Rac2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02439

Species: Human

Expression System: E. coli

GAP43 Protein, Human, Recombinant (His)

Cat.No: TMPY-02106

Species: Human

Expression System: HEK293 Cells

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