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Search Results for " mrg "

Targets Recommended: MRGPR Others

19

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T39295	Remlarsen MRG-201	Others	Others
	Remlarsen (MRG-201), a miR-29b mimic, functions as a miR-29b agonist with the potential to prevent the formation of fibrotic scars or cutaneous fibrosis.
T39294	Cobomarsen MRG-106,Cobomarsen	Others	Others
	Cobomarsen (MRG-106) is an oligonucleotide inhibitor targeting miR-155. This compound effectively suppresses various gene pathways involved in cell survival, such as JAK/STAT, MAPK/ERK, and PI3K/AKT. Cobomarsen is particularly valuable in the study of B-cell lymphoma.
T12104	MRGPRX1 agonist 1	MRGPR	GPCR/G Protein
	MRGPRX1 agonist 1 是高效的 Mas 相关 G 蛋白偶联受体 X1 激动剂(EC50:50 nM)，对 MRGPRC11 无活性。MRGPRC11 具有缓解疼痛的作用。
T63812	MrgprX2 antagonist-8	MRGPR	GPCR/G Protein
	MrgprX2 antagonist-8 是 MrgprX2 拮抗剂，能够用于研究炎症性疾病。
T61183	MRGPRX4 modulator-2	MRGPR	GPCR/G Protein
	MRGPRX4 modulator-2 是一种高效的 Mas相关G蛋白受体X4 （MRGPR X4）调节剂。MRGPRX4 modulator-2 可用于研究自身免疫性疾病和炎症。
T63766	MrgprX2 antagonist-7	Others	Others
	MrgprX2 antagonist-7 是一种抗过敏剂，具有明显的抗过敏效果，能够抑制肥大细胞脱颗粒。
T40268	MrgprX2 antagonist-4 MrgprX2 antagonist-4	Others	Others
	MrgprX2 antagonist-4 and compound B-51 E117, is a potent MrgprX2 antagonist. It specifically targets and inhibits the MrgprX2 receptor, making it suitable for investigating various inflammatory skin disorders.
T40176	MrgprX2 antagonist-5 MrgprX2 antagonist-5	Others	Others
	MrgprX2 antagonist-5, which acts as a potent antagonist of MrgprX2. It exhibits the ability to effectively inhibit the activity of MrgprX2, making it an ideal candidate for research related to inflammatory skin disorders.
T61332	MRGPRX4 modulator-1	Others	Others
	MRGPRX4 modulator-1 (compound 31-2) is a potent antagonist of the mas-related g-protein receptor X4 (MRGPR X4) with an IC50 < 100 nM against MRGPR4. It is utilized for the investigation of MRGPR X4 dependent diseases including itch, pain, and autoimmune disorders [1].
T60497	MRGPRX1 agonist 3	Others	Others
	MRGPRX1 agonist 3 (compound 1f) 是一种有效的正向变构调节剂，对Mas 相关 G 蛋白偶联受体 X1 (MRGPRX1)的EC50值为 0.22 μM，可用于研究神经性疼痛。
T40270	MrgprX2 antagonist-1 MrgprX2 antagonist-1	Others	Others
	MrgprX2 antagonist-1, is a novel MrgprX2 antagonist compound. It exhibits potential for exploration in studying cutaneous inflammatory disorders.
T40273	MrgprX2 antagonist-2 MrgprX2 antagonist-2	Others	Others
	MrgprX2 antagonist-2 is a potent antagonist of MrgprX2. It holds potential for investigating skin inflammatory disorders.
T28095	MrgX1-Activator-1	Others	Others
	MrgX1-Activator-1 is a MrgX1 receptor activator.
T40271	MrgprX2 antagonist-3 MrgprX2 antagonist-3	Others	Others
	MrgprX2 antagonist-3 is a potent inhibitor of MrgprX2. It holds promising potential for investigating skin inflammatory disorders.
T60466	MRGPRX1 agonist 2	Others	Others
	MRGPRX1 agonist 2 (compound 1a) 是有效的Mas 相关 G 蛋白偶联受体 X1 (MRGPRX1)的正变构调节剂（EC50 = 0.48 μM）。MRGPRX1 agonist 2 具有用于神经性疼痛的研究潜力。
T63578	Mrgx2 antagonist-1	Others	Others
	Mrgx2 antagonist-1 是 Mrgx2 (Mas-related Gene X2) 的有效拮抗剂，能够用于研究 Mrgx2 介导的疾病和紊乱。
T63394	MrgprX2 antagonist-6	Others	Others
	MrgprX2 antagonist-6 是一种高效抗过敏剂，对肥大细胞脱颗粒具有抑制作用。
T63549	MRGPRX1 agonist 4	Others	Others
	MRGPRX1 agonist 4 是有效的、口服具有活力的 Mas 相关 G 蛋白偶联受体 X1 (MRGPRX1)正向变构调节剂 (EC50: 0.1 μM)。MRGPRX1 agonist 4 表现出良好的代谢稳定性以及口服生物利用度。MRGPRX1 agonist 4 能够改善人源性 MRGPRX1 神经疼痛模型小鼠行为性热过敏反应。
T70340	JHU-58	Others	Others
	JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in substantia gelatinosa (SG) neurons in wild-type mice, but not in Mrg knockout mice, after peripheral nerve injury.

化合物

Cat.No: T39295

Synonym: MRG-201

Target: Others

Cat.No: T39294

Synonym: MRG-106,Cobomarsen

Target: Others

MRGPRX1 agonist 1

Cat.No: T12104

Target: MRGPR

MrgprX2 antagonist-8

Cat.No: T63812

Target: MRGPR

MRGPRX4 modulator-2

Cat.No: T61183

Target: MRGPR

MrgprX2 antagonist-7

Cat.No: T63766

Target: Others

MrgprX2 antagonist-4

Cat.No: T40268

Synonym: MrgprX2 antagonist-4

Target: Others

MrgprX2 antagonist-5

Cat.No: T40176

Synonym: MrgprX2 antagonist-5

Target: Others

MRGPRX4 modulator-1

Cat.No: T61332

Target: Others

MRGPRX1 agonist 3

Cat.No: T60497

Target: Others

MrgprX2 antagonist-1

Cat.No: T40270

Synonym: MrgprX2 antagonist-1

Target: Others

MrgprX2 antagonist-2

Cat.No: T40273

Synonym: MrgprX2 antagonist-2

Target: Others

MrgX1-Activator-1

Cat.No: T28095

Target: Others

MrgprX2 antagonist-3

Cat.No: T40271

Synonym: MrgprX2 antagonist-3

Target: Others

MRGPRX1 agonist 2

Cat.No: T60466

Target: Others

Mrgx2 antagonist-1

Cat.No: T63578

Target: Others

MrgprX2 antagonist-6

Cat.No: T63394

Target: Others

MRGPRX1 agonist 4

Cat.No: T63549

Target: Others

Cat.No: T70340

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03276	BLBP Protein, Human, Recombinant fatty acid binding protein 7, brain,FABPB,MRG,B-FAB...	Human	E. coli
	BLBP, also known as FABP7, is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP7 binds DHA with the highest affinity among all of the FABPs. FABPs may play roles in fatty acid uptake, transport, and metabolism. BLBP is expressed, during development, in radial glia by the activation of notch receptors. It was shown that reelin induces FABP7 expre...
TMPJ-00671	FABP7 Protein, Human, Recombinant (His) Fatty Acid-Binding Protein 7,Mammary-Derived Growth Inhibito...	Human	E. coli
	Fatty Acid-Binding Protein 7 (FABP7) is a cytoplasm protein that belongs to the Fatty-acid Binding Protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP7 is predominately expressed in brain and neural tissues. FABP7 is involved in fatty acid uptake and intracellular transport and is important in brain development. FABP7 plays a critical role in the transport of a so far unknow...
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His) Mas-related G-protein coupled receptor member X2,MRG	Human	E. coli
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway c...

重组蛋白

BLBP Protein, Human, Recombinant

Cat.No: TMPY-03276

Species: Human

Expression System: E. coli

FABP7 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00671

Species: Human

Expression System: E. coli

MRGPRX2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01640

Species: Human

Expression System: E. coli

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