Guajadial B acts as a Top1 catalytic inhibitor and delays Top1 poison-mediated DNA damage. Guajadial B shows cytotoxicities against five human cancer cell lines, it is the most effective having an IC50 value of 150 nM toward A549 cells.
Guajadial C acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. It shows cytotoxicity against five human cancer cell lines.
Guajadial shows α-glucosidase inhibitory activities significantly and its activity was better than that of Acarbose.Guajadial may act as Selective Estrogen Receptors Modulators (SERMs), therefore holding significant potential for anticancer therapy, it ex
Guajadial F acts as a Top1 catalytic inhibitor and can delay Top1 poison-mediated DNA damage. Guajadial F shows cytotoxicity against five human cancer cell lines.