首页工具

登录

搜索结果

Search Results for " telomere "

Targets Recommended: DNA/RNA Synthesis

5

抑制剂 & 化合物

1

化合物库

10

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L8200	抗衰老化合物库		3279 compounds
	3279 个抗衰老化合物的独特集合，可用于高通量筛选和高内涵筛选；

化合物库

抗衰老化合物库

Cat.No: L8200

Compounds: 3279

Cat. No.	Product Name	Target	Signaling Pathways
T8647	BCH001	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BCH001 是喹啉衍生物，是一种选择性PAPD5抑制剂。它可以恢复先天性角化病诱导的多能干细胞中的端粒酶活性和端粒长度。它对聚 (A)-特异性核糖核酸酶或几种其他多核苷酸聚合酶均无抑制作用。它可用于调控衰老。
T26892	Braco-19	Antiviral; Telomerase	DNA Damage/DNA Repair; Immunology/Inflammation
	Braco-19 是一种端粒酶/端粒抑制剂，也是一种 HAdV 病毒复制抑制剂，具有抗病毒活性，可减少脂肪细胞脂质空泡化，抑制人胶质母细胞瘤细胞中的增殖并降低端粒酶活性。
T62915	Dot1L-IN-7	Others	Others
	Dot1L-IN-7 (compound 25) 是一种选择性的、有效的端粒沉默 1 样蛋白 (DOT1L) 抑制剂 (IC50: 1.0 μM)。Dot1L-IN-7 能够选择性地杀死 MLL-AF9，且不影响 E2A-HLF 细胞的生长。
T82667	CRT0063465	Others	Others
	CRT0063465是一种同时针对人类PGK1和Stress Sensor DJ1的配体，其对PGK1的Kd值为24 μM。该化合物能够调节端粒蛋白复合体的形成及端粒长度。
T63072	ETP-47037	Others	Others
	ETP-47037 是一种 PI3Kα 异构体的有效抑制剂 (IC50: 0.99 nM)，能够抑制 PI3Kβ (IC50: 49.2 nM)、PI3Kδ (IC50: 7.13 nM) 和 PI3Kγ (IC50: 49.1 nM) 同工型。ETP-47037 具有潜力进行端粒保护化学调节的研究。

化合物

Cat.No: T8647

Target: DNA/RNA Synthesis

Cat.No: T26892

Target: Antiviral, Telomerase

Cat.No: T62915

Target: Others

Cat.No: T82667

Target: Others

Cat.No: T63072

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02298	ACYP2 Protein, Human, Recombinant (GST) ACYM,acylphosphatase 2, muscle type,ACYP	Human	E. coli
	Recent genome-wide association studies have identified genetic variants in ACYP2 and WFS1 that are associated with cisplatin-induced ototoxicity. We sought to explore the role of these genetic susceptibility factors to cisplatin-induced ototoxicity in patients with testicular cancer. Telomere length, as a marker of biological aging, has been reported to influence the risk of several age-related diseases, including ischemic stroke. Recent studies have identified the genetic variant within ACYP2 a...
TMPY-00452	SBDS Protein, Mouse, Recombinant (His) 4733401P19Rik,AI836084,CGI-97,SDS,Shwachman-Bodian-Diamond s...	Mouse	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His ta...
TMPY-00518	SBDS Protein, Human, Recombinant (His) CGI-97,Shwachman-Bodian-Diamond syndrome,SDS,SWDS	Human	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Human, Recombinant (His) is expressed in E. coli expression system with His ta...
TMPY-02399	TRF1 Protein, Human, Recombinant (His) TRF,telomeric repeat binding factor (NIMA-interacting) 1,hTR...	Human	Baculovirus Insect Cells
	Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell ...
TMPH-02183	CCT2 Protein, Human, Recombinant (His & SUMO) CCT2,99D8.1,CCT-beta,TCP-1-beta,CCTB,T-complex protein 1 sub...	Human	E. coli
	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. CCT2 Protein, Human, Recombinant (His & S...
TMPJ-00516	OBhFc1 Protein, Human, Recombinant (His) Suppressor of Cdc Thirteen Homolog,CST Complex Subunit STN1,...	Human	E. coli
	CST Complex Subunit STN1 (OBFC1) is a 368 amino acid protein that contains one OB DNA-binding domain. It is a member of the STN1 family. OBFC1 is component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has prob...
TMPY-03521	DcR3 Protein, Human, Recombinant (hFc) DCR3,tumor necrosis factor receptor superfamily member 6b,M6...	Human	Baculovirus Insect Cells
	Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tu...
TMPH-01237	POLQ Protein, Human, Recombinant (E. coli, His) DNA polymerase eta,POLQ,DNA polymerase theta	Human	E. coli
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPH-01238	POLQ Protein, Human, Recombinant (His) DNA polymerase eta,POLQ,DNA polymerase theta	Human	Baculovirus Insect Cells
	DNA polymerase that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumul...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,...	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...

重组蛋白

ACYP2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02298

Species: Human

Expression System: E. coli

SBDS Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00452

Species: Mouse

Expression System: E. coli

SBDS Protein, Human, Recombinant (His)

Cat.No: TMPY-00518

Species: Human

Expression System: E. coli

TRF1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02399

Species: Human

Expression System: Baculovirus Insect Cells

CCT2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02183

Species: Human

Expression System: E. coli

OBhFc1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00516

Species: Human

Expression System: E. coli

DcR3 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03521

Species: Human

Expression System: Baculovirus Insect Cells

POLQ Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01237

Species: Human

Expression System: E. coli

POLQ Protein, Human, Recombinant (His)

Cat.No: TMPH-01238

Species: Human

Expression System: Baculovirus Insect Cells

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼