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Search Results for " retinoblastoma "

Targets Recommended: Histone Demethylase

12

抑制剂 & 化合物

3

天然产物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T15648	KDM5-C70	Histone Demethylase	Chromatin/Epigenetic
	KDM5-C70 是 KDM5-C49 的乙酯衍生物，是一种有效的细胞渗透性泛 KDM5 组蛋白去甲基化酶抑制剂。它在骨髓瘤细胞中具有抗增殖作用，可诱导全基因组 H3K4me3 水平升高。
T8350	TPCK	Proteasome	Proteases/Proteasome; Ubiquitination
	TPCK 是丝氨酸蛋白酶抑制剂，通过与 HPV-18 E7 蛋白的视网膜母细胞瘤蛋白 (RB) 结合核心发生反应，并能够消除其 RB 结合能力。将它添加到培养基内，可修饰活角质形成细胞中的 E7 蛋白。
T7698	BS194 (2S,3S)-3-[[3-(异丙基)-7-[(苯基甲基)氨基]吡唑并[1,5-A]嘧啶-5-基]氨基]-1,2,4-丁三醇	CDK	Cell Cycle/Checkpoint
	BS194 是一种有效的细胞周期蛋白依赖性蛋白激酶 (CDK) 抑制剂。
T21314	Amsilarotene TAC-101,TAC 101,TAC101	CDK	Cell Cycle/Checkpoint
	Amsilarotene (TAC101) 是口服有活性的合成类视黄醇，对视黄酸受体 α (RAR-α) 具有选择性亲和力，对 RAR-α 和 RAR-β 的 Ki=为 2.4 nM 和 400 nM。它可造成人胃癌、卵巢癌细胞及肝细胞癌的凋亡，可用于研究癌症。
T9636	Dalpiciclib SHR-6390	CDK	Cell Cycle/Checkpoint
	Dalpiciclib (SHR-6390) 是一种高选择性、口服生物利用度和相当效力的 CDK4 和 CKD6 抑制剂，IC50 分别为 12.4 nM 和 9.9 nM。它通过抑制磷酸化 Rb 蛋白和诱导 G1 细胞周期阻滞在食管鳞状细胞癌中发挥有效的抗肿瘤活性。
T26855	BMS-665053 BMS665053	Others	Others
	BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM). In addi
T26456	A 83586C A83586C,A-83586C	Others	Others
	A-83586C is a depsipeptide antibiotic from Streptomyces karnatakensis with potent against Gram-positive activity in vitro. A-83586C acts as a highly potent inhibitor of beta-catenin/TCF4 signaling within cancer cells, while simultaneously downregulating o
T70377	BAY 61-3606 HCl	Others	Others
	BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used i...
T72928	CDK4/6-IN-15	Others	Others
	CDK4/6-IN-15 是一种口服有效和选择性 CDK4/6抑制剂。CDK4/6-IN-15 能有效抑制癌细胞生长。CDK4/6-IN-15 将细胞周期阻滞在 G1 期，并抑制视网膜母细胞瘤肿瘤抑制蛋白 (Rb) 在 S780 位点的磷酸化和 E2 因子 (E2F) 调控的基因表达。
T69196	AG-012986	Others	Others
	AG-012986 is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 showed antiproliferative activities in vitro with IC(50)s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 was seen (tumor growth inhibition, >83.1%) in 10 of 11 human xenograft tumor models. AG-012986 also showed dose-dependent retinoblastoma Ser(795) hy...
T62235	CDK-IN-9	Others	Others
	CDK-IN-9 (compound 24) 是一种 CDK 的有效抑制剂。CDK-IN-9 也是一种能够诱导 CDK12 和 DDB1 相互作用的分子胶，能够作用于 CDK2/E (IC50: 4 nM) 。CDK-IN-9 能够导致细胞周期蛋白 K (cyclin K) 的多泛素化及其随后的降解。CDK-IN-9 可以利用去磷酸化视网膜母细胞瘤蛋白和RNA 聚合酶 II，进而诱导细胞凋亡 (apoptosis)。
T69197	AG-012986 HCl	Others	Others
	AG-012986 HCl is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 HCl showed antiproliferative activities in vitro with IC(50)s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 HCl was seen (tumor growth inhibition, >83.1%) in 10 of 11 human xenograft tumor models. AG-012986 HCl also showed dose-dependent retinoblas...

化合物

Cat.No: T15648

Target: Histone Demethylase

Cat.No: T8350

Target: Proteasome

Cat.No: T7698

Synonym: (2S,3S)-3-[[3-(异丙基)-7-[(苯基甲基)氨基]吡唑并[1,5-A]嘧啶-5-基]氨基]-1,2,4-丁三醇

Target: CDK

Cat.No: T21314

Synonym: TAC-101,TAC 101,TAC101

Target: CDK

Cat.No: T9636

Synonym: SHR-6390

Target: CDK

Cat.No: T26855

Synonym: BMS665053

Target: Others

Cat.No: T26456

Synonym: A83586C,A-83586C

Target: Others

BAY 61-3606 HCl

Cat.No: T70377

Target: Others

Cat.No: T72928

Target: Others

Cat.No: T69196

Target: Others

Cat.No: T62235

Target: Others

Cat.No: T69197

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T72100	D-erythro-Sphingosine hydrochloride Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride	Others	Others
	D-erythro-Sphingosine (Erythrosphingosine) hydrochloride 是一种特异性 TRPM3活化剂。D-erythro-Sphingosine 还诱导视网膜母细胞瘤蛋白 (retinoblastoma protein) 去磷酸化。
T4110	Perivine Perivin,派利文碱	Others	Others
	Perivine (Perivin) 以视网膜母细胞瘤相关蛋白 (RbAp48) 为靶点，能够解决 RbAp48-FOG-1 复合物的不稳定性。Perivine 可用于研究阿尔茨海默病。

天然产物

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

D-erythro-Sphingosine hydrochloride

Cat.No: T72100

Synonym: Erythrosphingosine hydrochloride,trans-4-Sphingenine hydrochloride,erythro-C18-Sphingosine hydrochloride,Erythrosphingosine hydrochloride ; erythro-C18-Sphingosine hydrochloride ; trans-4-Sphingenine hydrochloride

Target: Others

Cat.No: T4110

Synonym: Perivin,派利文碱

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02031	RBL2 Protein, Human, Recombinant (His) Retinoblastoma-related protein 2,pRb2,Retinobla...	Human	E. coli
	RBL2 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPY-05251	RbAp48 Protein, Mouse, Recombinant (His) RBAP48,retinoblastoma binding protein 4,mRbAp48	Mouse	Baculovirus Insect Cells
	RbAp48 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is Q09028-1.
TMPY-01713	RbAp48 Protein, Human, Recombinant (His) retinoblastoma binding protein 4,NURF55,RBAP48,lin-...	Human	Baculovirus Insect Cells
	RbAp48 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is Q09028-1.
TMPH-01483	RBBP7 Protein, Human, Recombinant (His & SUMO) Histone acetyltransferase type B subunit 2,Histone-binding p...	Human	E. coli
	RBBP7 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.8 kDa and the accession number is Q16576.
TMPH-02866	RBBP9 Protein, Mouse, Recombinant (His) Retinoblastoma-binding protein 9,Putative hydrolase...	Mouse	P. pastoris (Yeast)
	Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1. RBBP9 Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 22.4 kDa and t...
TMPH-00975	DDX1 Protein, Human, Recombinant (His & Myc) DBP-RB,DDX1,ATP-dependent RNA helicase DDX1,DEAD box protein...	Human	E. coli
	DDX1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-00989	ARID4B Protein, Human, Recombinant (His) RBP1L1,SAP180,ARID domain-containing protein 4B,80 kDa Sin3-...	Human	E. coli
	ARID4B Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.8 kDa and the accession number is Q4LE39.
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPJ-00963	CDKN2C Protein, Human, Recombinant (His) Cyclin-Dependent Kinase 4 Inhibitor C,p18-INK4c,CDKN2C,p18-I...	Human	E. coli
	Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis,...
TMPJ-00459	Esterase D Protein, Human, Recombinant (His) FGH,Methylumbelliferyl-Acetate Deacetylase,ESD,S-Formylgluta...	Human	E. coli
	Human Esterase D is a cytoplasmic serine hydrolase that belongs to the esterase D family. Esterase D is involved in the detoxification of formaldehyde. Esterase D plays a part in a variety of substrates, including O-acetylated sialic acids, which may involves in the recycling of sialic acids. Esterase D is used as a genetic marker for retinoblastoma and Wilson’s disease.
TMPJ-00703	Gankyrin Protein, Human, Recombinant PSMD10,Gankyrin,26S Proteasome Non-ATPase Regulatory Subunit...	Human	E. coli
	Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.
TMPY-03391	ESD Protein, Human, Recombinant (His) esterase D,FGH	Human	E. coli
	Esterase D, also known as ESD, is a serine hydrolase that belongs to the esterase D family. Esterase D is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. Esterase D gene is used as a genetic marker and a diagnostic tool for retinoblastoma, Wilson's disease and other hereditary or acquired diseases controlled by genes located at the 13 chromosome 13q14 region.
TMPJ-00265	Serpin F1 Protein, Mouse, Recombinant Pedf,Caspin,Stromal cell-derived factor 3,Sdf3,Pigment epith...	Mouse	E. coli
	Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and testes. It induces extensive neuronal differentiation in retinoblastoma cells. It is potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, exhibits no serine protease inhibitory activi...
TMPY-01711	Serpin B2 Protein, Human, Recombinant (GST) PAI,serpin peptidase inhibitor, clade B (ovalbumin), member ...	Human	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.SerpinB2, also known as Plasminogen activator inhibitor 2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor and PAI2, is a cytoplasm protein that belongs to the serpin fa...
TMPY-02495	p19 INK4d Protein, Human, Recombinant (GST) p19-INK4D,INK4D,cyclin-dependent kinase inhibitor 2D (p19, i...	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-ind...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His) G1/S-specific cyclin-D2,CCND2	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ...

重组蛋白

RBL2 Protein, Human, Recombinant (His)

Cat.No: TMPH-02031

Species: Human

Expression System: E. coli

RbAp48 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05251

Species: Mouse

Expression System: Baculovirus Insect Cells

RbAp48 Protein, Human, Recombinant (His)

Cat.No: TMPY-01713

Species: Human

Expression System: Baculovirus Insect Cells

RBBP7 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01483

Species: Human

Expression System: E. coli

RBBP9 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02866

Species: Mouse

Expression System: P. pastoris (Yeast)

DDX1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00975

Species: Human

Expression System: E. coli

ARID4B Protein, Human, Recombinant (His)

Cat.No: TMPH-00989

Species: Human

Expression System: E. coli

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

CDKN2C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00963

Species: Human

Expression System: E. coli

Esterase D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00459

Species: Human

Expression System: E. coli

Gankyrin Protein, Human, Recombinant

Cat.No: TMPJ-00703

Species: Human

Expression System: E. coli

ESD Protein, Human, Recombinant (His)

Cat.No: TMPY-03391

Species: Human

Expression System: E. coli

Serpin F1 Protein, Mouse, Recombinant

Cat.No: TMPJ-00265

Species: Mouse

Expression System: E. coli

Serpin B2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01711

Species: Human

Expression System: Baculovirus Insect Cells

p19 INK4d Protein, Human, Recombinant (GST)

Cat.No: TMPY-02495

Species: Human

Expression System: E. coli

CCND2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00936

Species: Human

Expression System: E. coli

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